Effects and Safety of Oliceridine in Anesthesia Induction:A Randomised Controlled Trial

Completed 120 enrolled Tangshan Maternal and Child Health Hospital

RandomizedParallel-groupQuadruple-blindTreatment

Summary

to investigate whether oliceridine is safe and effective for induction of anesthesia by comparing henodynamic changes before and after endotracheal intubation with sufentanil

Timeline

Start: 2025-10-01
Primary completion: 2025-12-15
Completion: 2025-12-31

Publications

Background Simons P, van der Schrier R, van Lemmen M, Jansen S, Kuijpers KWK, van Velzen M, Sarton E, Nicklas T, Michalsky C, Demitrack MA, Fossler M, Olofsen E, Niesters M, Dahan A. Respiratory Effects of Biased Ligand Oliceridine in Older Volunteers: A Pharmacokinetic-Pharmacodynamic Comparison with Morphine. Anesthesiology. 2023 Mar 1;138(3):249-263. doi: 10.1097/ALN.0000000000004473.
Background Stahl EL, Schmid CL, Acevedo-Canabal A, Read C, Grim TW, Kennedy NM, Bannister TD, Bohn LM. G protein signaling-biased mu opioid receptor agonists that produce sustained G protein activation are noncompetitive agonists. Proc Natl Acad Sci U S A. 2021 Nov 30;118(48):e2102178118. doi: 10.1073/pnas.2102178118.
Background Yang W, Zhou R, Zhou X, Chen X, Zhou D, Zhang X. Effective Dose of Oliceridine Fumarate Co-Administered with Remimazolam in Suppressing Gastroscope Insertion Responses for Adults. Drug Des Devel Ther. 2025 Jun 10;19:5033-5041. doi: 10.2147/DDDT.S527586. eCollection 2025.
Background Ma B, Li Y, Leng C, Ji A, Zhang N, Tao X, Cao Q, Wang S. A Comparative Evaluation of the Safety and Efficacy of Oliceridine and Sufentanil in Gastrointestinal Endoscopy: A Single-Center, Randomized Controlled Trial. Drug Des Devel Ther. 2025 Jun 17;19:5111-5121. doi: 10.2147/DDDT.S512529. eCollection 2025.
Background Iannuzzi E, Iannuzzi M, Cirillo V, Viola G, Parisi R, Cerulli A, Chiefari M. Peri-intubation cardiovascular response during low dose remifentanil or sufentanil administration in association with propofol TCI. A double blind comparison. Minerva Anestesiol. 2004 Mar;70(3):109-15.
Background Teong CY, Huang CC, Sun FJ. The Haemodynamic Response to Endotracheal Intubation at Different Time of Fentanyl Given During Induction: A Randomised Controlled Trial. Sci Rep. 2020 Jun 1;10(1):8829. doi: 10.1038/s41598-020-65711-9.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Oliceridine	Other / unclassified	0.13 mg/kg	—
Comparator	Sufentanil	Other / unclassified	0.5 ug/kg	—

Indications

No indication recorded.