drugset
drugset / Trial / NCT07378293

Effects of Selected Statins on Blood Glucose Levels in Healthy Volunteers

NCT07378293 ↗

Phase 1 Not yet recruiting 100 enrolled Shaheed Benazir Bhutto University Sheringal Dir Upper Khyber Medical University Peshawar · collab
RandomizedParallel-groupTriple-blindTreatment

Summary

This Phase I randomized clinical trial aims to investigate the short-term effects of three commonly prescribed statins (atorvastatin, rosuvastatin, and simvastatin) at different dose levels on blood glucose homeostasis in healthy volunteers. The study will assess changes in fasting blood glucose, insulin, and C-peptide levels following two days of statin administration under controlled conditions. The research seeks to provide comparative data on the potential diabetogenic effects of these medications.

Timeline

Start
2026-03-01
Primary completion
2026-12-30
Completion
2027-02-20

Drugs

EvaluationDrugModalityDoseRoute
Subject Atorvastatin Small molecule 10 mg Oral
Subject Atorvastatin Small molecule 20 mg Oral
Subject Atorvastatin Small molecule 40 mg Oral
Subject Rosuvastatin Small molecule 5 mg Oral
Subject Rosuvastatin Small molecule 20 mg Oral
Subject Rosuvastatin Small molecule 40 mg Oral
Subject Simvastatin Small molecule 10 mg Oral
Subject Simvastatin Small molecule 20 mg Oral
Subject Simvastatin Small molecule 40 mg Oral

Indications

diabetes mellitus