drugset / Trial / NCT07382245

Efficacy of Silver Diamine Fluoride Versus Nano-Silver Fluoride in Arresting Active Dentin Caries in Primary Teeth in Young Children

NCT07382245

Not yet recruiting 60 enrolled October University for Modern Sciences and Arts
RandomizedParallel-groupOpen-labelTreatment

Summary

Early childhood caries is a major public health problem affecting preschool children worldwide. Silver Diamine Fluoride is a well-established non-invasive treatment for arresting caries; however, it causes black discoloration of treated lesions. Nano-Silver Fluoride has been introduced as an alternative that may arrest caries without discoloration. This randomized clinical trial aims to compare the efficacy of Silver Diamine Fluoride and Nano-Silver Fluoride in arresting active dentin caries in primary teeth and to assess discoloration, post-operative pain, and parental satisfaction over a 12-month follow-up period.

Timeline

Start
2026-01-30
Primary completion
2026-02-25
Completion
2026-03-15

Drugs

EvaluationDrugModalityDoseRoute
Subject nanosilver fluoride Unknown Topical
Comparator silver diammine fluoride Small molecule Topical

Indications