silver diammine fluoride
Trials 44
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 02 trials | ||||||
| Phase 0 | NCT04255251 | Jun 2021 → Jan 2023 | dentin caries, root caries | University of New England | Unknown | No outcome recorded |
| Phase 0 | NCT03089567 | Sep 2017 → Jan 2018 | dental caries | Yale University | Withdrawn | No outcome recorded Stop: Enrollment |
| Phase 11 trial | ||||||
| Phase 1 | NCT06316323 | Feb → Sep 2023 | dental caries | Universiti Teknologi Mara | Completed | No outcome recorded |
| Phase 28 trials | ||||||
| Phase 2 | NCT07455604 | Jan 2026 → Aug 2028 expected | dental caries | The University of Hong Kong | Active not recruiting | No outcome recorded |
| Phase 2 | NCT07371117 | Nov 2025 → Feb 2026 | dental caries | University of Jazan | Completed | No outcome recorded |
| Phase 2 | NCT06797882 | Jan 2025 → Aug 2026 overdue | enamel caries, smooth surface dental caries | National University of Malaysia | Not yet recruiting | No outcome recorded |
| Phase 2 | NCT06241261 | Jan 2024 → Aug 2027 expected | dental caries | The University of Hong Kong | Active not recruiting | No outcome recorded |
| Phase 2 | NCT05670743 | Mar → Jun 2023 | dental caries | Advantage Silver Dental Arrest, LLC | Completed | No outcome recorded |
| Phase 2 | NCT04186663 | Aug 2019 → Mar 2020 | dental caries | Advantage Silver Dental Arrest, LLC | Completed | No outcome recorded |
| Phase 2 | NCT03855527 | Jan 2018 → Jan 2019 | dental caries | Nourhan M.Aly | Completed | No outcome recorded |
| Phase 2 | NCT04184271 | Aug → Sep 2017 | dental caries | Advantage Silver Dental Arrest, LLC | Completed | No outcome recorded |
| Phase 2/37 trials · 1 met primary | ||||||
| Phase 2/3 | NCT04354636 | Sep 2021 → Oct 2022 | dental caries | Cairo University | Completed | No outcome recorded |
| Phase 2/3 | NCT05084001 | Mar 2020 → Jul 2023 | pit and fissure surface dental caries | The University of Hong Kong | Unknown | No outcome recorded |
| Phase 2/3 | NCT04213573 | Jan → Oct 2020 | dental caries | University of Baghdad | Suspended | No outcome recorded |
| Phase 2/3 | NCT04236830 | Nov 2019 → Mar 2021 | dental pulp calcification, tooth hard tissue disease | Nourhan M.Aly | Completed | No outcome recorded |
| Phase 2/3 | NCT04654624 | Oct 2018 → Oct 2019 | dental caries | Nourhan M.Aly | Completed | No outcome recorded |
| Phase 2/3 | NCT02742142 | Oct 2012 → Dec 2015 | dental caries | The University of Hong Kong | Completed | No outcome recorded |
| Phase 2/3 | NCT02360124 | Jan 2012 → Apr 2015 | root caries | The University of Hong Kong | Completed | Met primary |
| Phase 35 trials · 1 met primary | ||||||
| Phase 3 | NCT04889196 | Sep 2021 → May 2022 | dental caries | Sarah Abdalla Ibrahim Abdalla | Unknown | No outcome recorded |
| Phase 3 | NCT05791669 | Aug 2021 → Aug 2022 | dental caries | Postgraduate Institute of Dental Sciences Rohtak | Completed | No outcome recorded |
| Phase 3 | NCT04794426 | Jun 2021 → Jul 2022 | dental caries | Noura Mohamed Alhosaini | Unknown | No outcome recorded |
| Phase 3 | NCT03649659 | Oct 2018 → Apr 2023 | — | University of Michigan | Terminated | Met primary Stop: Enrollment |
| Phase 3 | NCT02536040 | Jan → Jul 2016 | dental caries | Advantage Dental Services, LLC | Completed | No outcome recorded |
| Phase 49 trials · 2 missed | ||||||
| Phase 4 | NCT07194629 | Oct 2025 → Nov 2026 expected | dental caries | University of Montreal | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT05872542 | Jun → Dec 2023 | dental caries | Umm Al-Qura University | Unknown | No outcome recorded |
| Phase 4 | NCT07023939 | May 2023 → Jan 2024 | dental caries | Beirut Arab University | Completed | Missed primary |
| Phase 4 | NCT03881020 | Aug 2020 → Nov 2021 | dental caries | Ain Shams University | Completed | Missed primary |
| Phase 4 | NCT04777968 | Aug → Dec 2020 | dental caries | Cairo University | Completed | No outcome recorded |
| Phase 4 | NCT05314660 | Jan 2020 → Jan 2022 | dental caries | Mansoura University | Completed | No outcome recorded |
| Phase 4 | NCT03554980 | Dec 2018 → Nov 2019 | dental caries | Cairo University | Unknown | No outcome recorded |
| Phase 4 | NCT03557996 | Dec 2018 → Nov 2019 | dental caries | Cairo University | Unknown | No outcome recorded |
| Phase 4 | NCT03568474 | Oct 2018 → Oct 2019 | dental caries | Cairo University | Unknown | No outcome recorded |
| Phase not applicable12 trials | ||||||
| — | NCT07861321 | Oct 2026 → Oct 2028 expected | dental caries | A.T. Still University of Health Sciences | Not yet recruiting | No outcome recorded |
| — | NCT07181967 | Sep → Dec 2025 overdue | dental caries | Assiut University | Recruiting | No outcome recorded |
| — | NCT07447583 | Aug 2024 | dental caries | TC Erciyes University | Completed | No outcome recorded |
| — | NCT07125937 | May 2024 → May 2025 | dental caries | HITEC-Institute of Medical Sciences | Completed | No outcome recorded |
| — | NCT05655286 | Jan 2023 → May 2024 | dental caries | The University of Hong Kong | Completed | No outcome recorded |
| — | NCT06293547 | Aug 2022 → Oct 2023 | — | Cumhuriyet University | Completed | No outcome recorded |
| — | NCT05425368 | Aug 2022 → Oct 2023 | dental caries | Cairo University | Unknown | No outcome recorded |
| — | NCT05249231 | Apr → Jul 2022 | dental caries | Cairo University | Unknown | No outcome recorded |
| — | NCT05265104 | Mar 2021 → Apr 2022 | dental caries | National Research Centre, Egypt | Completed | No outcome recorded |
| — | NCT07153328 | Jan 2021 → Mar 2024 | dental caries | Beaty Dent | Completed | No outcome recorded |
| — | NCT05296213 | Dec 2019 → Dec 2021 | enamel caries | Mansoura University | Completed | No outcome recorded |
| — | NCT03185104 | Nov 2013 → Jun 2017 | root caries | The University of Hong Kong | Unknown | No outcome recorded |
| Comparator or background therapy14 trials | ||||||
| Phase 0 | NCT06489093 Comparator | Jul 2024 → May 2025 | smooth surface dental caries | Plovdiv Medical University | Unknown | No outcome recorded |
| Phase 1 | NCT05941429 Comparator | Feb → Nov 2024 overdue | dental caries | Cairo University | Active not recruiting | No outcome recorded |
| Phase 1 | NCT04561934 Comparator | Dec 2020 | dental caries | Cairo University | Unknown | No outcome recorded |
| Phase 3 | NCT05761041 Comparator | Mar 2022 → Mar 2023 | dental caries | Alexandria University | Completed | Missed primary |
| Phase 3 | NCT05221749 Comparator | Mar → Apr 2022 | dental caries | Nour Ammar, BDS | Terminated | No outcome recorded |
| Phase 3 | NCT02019160 Comparator | Sep 2014 → Jun 2018 | dental caries | The University of Hong Kong | Completed | Met primary |
| Phase 3 | NCT02385474 Comparator | Mar 2013 → Mar 2016 | dental caries | The University of Hong Kong | Completed | No outcome recorded |
| Phase 4 | NCT06699199 Comparator | Nov 2023 → Jun 2025 overdue | dental caries | King Abdulaziz University | Recruiting | No outcome recorded |
| Phase 4 | NCT05772039 Comparator | Jan 2022 → Jul 2023 | dentin caries | Universiti Sains Malaysia | Unknown | No outcome recorded |
| Phase 4 | NCT04196829 Comparator | Jan 2020 → Aug 2021 | dental caries | Cairo University | Unknown | No outcome recorded |
| Phase 4 | NCT03563534 Comparator | Sep 2017 → Jun 2019 | dental caries | Cairo University | Unknown | No outcome recorded |
| — | NCT07382245 Comparator | Jan → Feb 2026 overdue | dentin caries | October University for Modern Sciences and Arts | Not yet recruiting | No outcome recorded |
| — | NCT05255913 Comparator | Mar 2022 → Jul 2023 | dental caries | Alexandria University | Completed | No outcome recorded |
| — | NCT05748054 Comparator | Nov 2019 → Oct 2020 | dental caries | King Abdullah University Hospital | Completed | No outcome recorded |
Evidence & citations 11 cited values
Every value below carries the sentence it was read from. 67 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Silver Diammine Fluoride | ClinicalTrials.gov intervention name — accepted as the source's own label NCT05772039 ↗ |
| Known as | Advantage Arrest | “The intervention consists of a single topical application of either ClearDefense® Nano Silver Fluoride (3% sodium fluoride + 0.2% silver ion) or AdvantageArrest® Silver Diamine...” NCT07861321 ↗2“one drop of SDF (Advantage Arrest ™, Elevate Oral Care, USA) was placed into a disposable dish” NCT07023939 ↗ “38% Silver Diamine Fluoride (Advantage Arrest™, Elevate Oral Care LLC)” NCT07125937 ↗ |
| Known as | diammine silver fluoride | ClinicalTrials.gov intervention name — accepted as the source's own label NCT02536040 ↗ |
| Known as | Riva Star | “Intervention 1 will receive standard OHI (every three months) and application of Silver Diamine Fluoride (SDF (Riva Star, SDI Limited., Australia) every six months.” NCT06797882 ↗2“SDF-KI (riva star, SDI.Ltd )was applied ( as a professional application) by micro brush over the early enamel lesions” NCT05296213 ↗ “Application of 38% SDF (Riva Star, SDI, Bayswater, Australia)” NCT04561934 ↗ |
| Known as | Saforide | “a 38% SDF solution (Saforide, Toyo Seiyaku Kasei Co. Ltd, Osaka, Japan) instead of the placebo solution was painted onto the exposed tooth root surfaces.” NCT02742142 ↗1“38% SDF (Saforide, Toyo Seiyaku Kasei Co. Ltd., Japan)” NCT05084001 ↗ |
| Known as | SDF | “The intervention consists of a single topical application of either ClearDefense® Nano Silver Fluoride (3% sodium fluoride + 0.2% silver ion) or AdvantageArrest® Silver Diamine...” NCT07861321 ↗26“The aim of the study is to compare the clinical efficacy of Silver diamine fluoride (SDF) and laboratory prepared green synthesized Nano-silver fluoride on early enamel lesions...” NCT06489093 ↗ “In this 12-month randomized active-controlled clinical trial, we compare two post-treatment instructions for silver diamine fluoride (SDF) therapy in arresting dentine caries.” PMID 37366668 ↗ Jun 2023 “This umbrella review comprehensively appraised evidence for silver diamine fluoride (SDF) to arrest and prevent root and coronal caries by summarizing systematic reviews.” PMID 31299955 ↗ Jul 2019 “Silver Diamine Fluoride (SDF) has gained attention as one of the minimally invasive modalities to manage ECC although it causes black staining of treated carious lesions.” PMID 37789300 ↗ Oct 2023 “The World Health Organisation (WHO) included silver diamine fluoride (SDF) in the WHO Model List of Essential Medicines for the management of early childhood caries.” PMID 39727476 ↗ Dec 2024 “Intervention 1 will receive standard OHI (every three months) and application of Silver Diamine Fluoride (SDF (Riva Star, SDI Limited., Australia) every six months.” NCT06797882 ↗ “Recently, Silver Diamine Fluoride (SDF) 38% has been introduced to the market as an efficient solution for promoting oral health and arresting active caries.” NCT07194629 ↗ “Previous studies have recommended that Silver diamine fluoride (SDF) solution would exert a preventive result in managing early childhood caries ECC.” NCT04889196 ↗ “Previous studies have recommended that Silver diamine fluoride (SDF) solution would exert a preventive result in managing early childhood caries ECC.” NCT04794426 ↗ “Studies have proven that silver diamine fluoride (SDF) is a topical fluoride that has the ability to effectively arrest and prevent dental caries.” NCT04777968 ↗ |
| Known as | SDF-KI | “SDF-KI (riva star, SDI.Ltd )was applied ( as a professional application) by micro brush over the early enamel lesions” NCT05296213 ↗ |
| Known as | silver diamine fluoride | “The intervention consists of a single topical application of either ClearDefense® Nano Silver Fluoride (3% sodium fluoride + 0.2% silver ion) or AdvantageArrest® Silver Diamine...” NCT07861321 ↗53“Silver Diamine Fluoride (SDF) has gained attention as one of the minimally invasive modalities to manage ECC although it causes black staining of treated carious lesions.” PMID 37789300 ↗ Oct 2023 “Silver Diamine Fluoride (38%) applied to the carious lesion in the primary molars with a brush and the tooth is sealed with a stainless steel crown” NCT05265104 ↗ “Application of 38% silver diamine fluoride (Riva star 38%, SDI) using a microapplicator on the carious lesion.” NCT06489093 ↗ “concentrations (12% or 38%) of silver diamine fluoride (SDF) and 2 periodicity of application” PMID 28846469 ↗ Aug 2017 “Silver diamine fluoride that will be applied during atraumatic restorative treatment” NCT04354636 ↗ “Children with active caries will receive 38% silver diamine fluoride treatment” NCT05655286 ↗ “included the application of 38% silver diamine fluoride (SDF) followed by ART” NCT07023939 ↗ “Silver diamine fluoride for managing carious lesions: an umbrella review.” PMID 31299955 ↗ Jul 2019 “a 38% silver diamine fluoride (SDF) solution” PMID 30931709 ↗ Feb 2019 “silver diamine fluoride” NCT02019160 ↗ |
| Known as | Silver diamine fluoride- potassium iodide | ClinicalTrials.gov intervention name — accepted as the source's own label NCT05296213 ↗ |
| Modality | Small molecule | “SDF is a compound of silver, fluoride, and ammonia” NCT07194629 ↗ |
| Route | Topical | “topical semiannual application of a 25% silver nitrate (AgNO3) solution followed by a 5% sodium fluoride (NaF) varnish with that of a 38% silver diamine fluoride (SDF) solution” PMID 30931709 ↗ Feb 2019 |