SDF vs Fluoride Varnish for Streptococcus Mutans Reduction in Children

Summary

This randomized split-mouth clinical trial will compare the effectiveness of 38% silver diamine fluoride (SDF) versus 5% sodium fluoride varnish (FV) in reducing salivary Streptococcus mutans levels in children with bilateral caries. Each participant will receive SDF on one side of the mouth and FV on the contralateral side. The primary outcome is change in Dentocult SM Strip Mutans scores in plaque over 3 months. Secondary outcomes include plaque index, bleeding on probing, and adverse events.

Timeline

Start

2025-09-15

Primary completion

2025-12-15

Completion

2025-12-30

Drugs

Indications