drugset / Trial / NCT07371117
Effect Of Three Remineralizing Agents On Early Childhood Caries
RandomizedParallel-groupQuadruple-blindTreatment
Summary
Early Childhood Caries (ECC) remains a global public health concern, necessitating minimally invasive, fluoride-based alternatives to conventional restorative therapy. Silver Diamine Fluoride (SDF), Sodium Fluoride with Casein Phosphopeptide-Amorphous Calcium Phosphate (NaF + CPP-ACP), and Acidulated Phosphate Fluoride (APF) gel are widely employed chemotherapeutic agents; however, comparative clinical evidence of their effectiveness in ECC management remains limited. This randomized controlled clinical trial will evaluate and compare the efficacy of SDF gel, NaF + CPP-ACP, and APF gel in arresting and preventing ECC.
Timeline
- Start
- 2025-11-01
- Primary completion
- 2026-02-20
- Completion
- 2026-02-25
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Acidulated Phosphate Fluoride | Unknown | 1.23 % | Topical |
| Subject | Casein phosphopeptide amorphous calcium phosphate | Peptide | — | Topical |
| Subject | silver diammine fluoride | Small molecule | 38 % | Topical |
| Subject | sodium fluoride | Unknown | — | Topical |