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Drugs / Casein phosphopeptide amorphous calcium phosphate
last change Feb 2026 re-read 9 days ago

Casein phosphopeptide amorphous calcium phosphate

also known as CPP-ACP · (CPP-ACP), Tooth Mousse (MI Paste) (GC Corporation, Tokyo, Japan) · tooth mousse

Peptide

Developed for
dental caries · enamel caries · smooth surface dental caries · tooth resorption
Investigated by
Alexandria University · Hams Hamed Abdelrahman · Kırıkkale University · Mansoura University · National Research Centre, Egypt · Riyadh Elm University
+1 more · University of Jazan

Trials 7

today NCT07371117 · Ph 2 NCT06821724 · not/applicable NCT06051981 · Ph 4 NCT06566833 · Ph 0 NCT04303767 · Ph 2 NCT05296213 · not/applicable NCT04124887 · not/applicable
20172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT06566833 Aug 2023 → Oct 2024 — Alexandria University Completed No outcome recorded
Phase 22 trials
Phase 2 NCT07371117 Nov 2025 → Feb 2026 dental caries University of Jazan Completed No outcome recorded
Phase 2 NCT04303767 Mar → Aug 2020 dental caries Hams Hamed Abdelrahman Unknown No outcome recorded
Phase 41 trial
Phase 4 NCT06051981 Oct 2023 → Feb 2024 — Riyadh Elm University Unknown No outcome recorded
Phase not applicable3 trials
— NCT06821724 Dec 2024 → Jan 2025 smooth surface dental caries National Research Centre, Egypt Completed No outcome recorded
— NCT05296213 Dec 2019 → Dec 2021 enamel caries Mansoura University Completed No outcome recorded
— NCT04124887 Feb 2017 → Feb 2018 tooth resorption Kırıkkale University Completed No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 7 sources stand behind the page.

FieldValueCited text
Known as Casein Phosphopeptide-Amorphous Calcium Phosphate “Sodium Fluoride with Casein Phosphopeptide-Amorphous Calcium Phosphate (NaF + CPP-ACP)” NCT07371117 ↗
6

NCT06566833 ↗

NCT06821724 ↗

NCT06051981 ↗

NCT04303767 ↗

NCT04124887 ↗

NCT05296213 ↗
Known as (CPP-ACP), Tooth Mousse (MI Paste) (GC Corporation, Tokyo, Japan) “(CPP-ACP), Tooth Mousse® (MI Paste®) (GC Corporation, Tokyo, Japan)” NCT06051981 ↗
Known as CPP-ACP “CPP-ACP (tooth mousse, GC, Matraville Sydney, Australia) was applied by using micro brush over the early enamel lesions” NCT05296213 ↗
1

“Sodium Fluoride with Casein Phosphopeptide-Amorphous Calcium Phosphate (NaF + CPP-ACP)” NCT07371117 ↗
Known as tooth mousse “CPP-ACP (tooth mousse, GC, Matraville Sydney, Australia) was applied by using micro brush over the early enamel lesions” NCT05296213 ↗
Modality Peptide “casein phoshphopeptide amorphous calcium phosphate fluoride (CPP-ACPF )” NCT06566833 ↗
Route Topical “was applied by using micro brush over the early enamel lesions on the buccal surface of the molar teeth twice daily” NCT05296213 ↗