[Effects of Selected Statins on Cardiovascular Parameters in Healthy Volunteers]

Phase 1 Not yet recruiting 100 enrolled Shaheed Benazir Bhutto University Sheringal Dir Upper Khyber Medical University Peshawar · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

This study is a Phase I randomized clinical trial aiming to investigate the short-term effects of three commonly prescribed statins i.e (Atorvastatin, Rosuvastatin, and Simvastatin) at different dose levels i.e lo,median and high doses on cardiovascular parameters i.e Blood pressure and ECG morphology in healthy volunteers. The study will assess changes in blood pressure and ECG morphology following two days of statin administration under controlled conditions.

Timeline

Start: 2026-03-01
Primary completion: 2026-12-30
Completion: 2027-02-20

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Atorvastatin	Small molecule	10 mg	Oral
Subject	Atorvastatin	Small molecule	20 mg	Oral
Subject	Atorvastatin	Small molecule	40 mg	Oral
Subject	Rosuvastatin	Small molecule	5 mg	Oral
Subject	Rosuvastatin	Small molecule	20 mg	Oral
Subject	Rosuvastatin	Small molecule	40 mg	Oral
Subject	Simvastatin	Small molecule	10 mg	Oral
Subject	Simvastatin	Small molecule	20 mg	Oral
Subject	Simvastatin	Small molecule	40 mg	Oral

Indications

No indication recorded.