An Assessment of the Efficacy and Safety of Employing a Duosomal Chemical Peel for Aesthetic Enhancement in the Periocular and Facial Regions

Summary

This study will employ an experimental, prospective, longitudinal, and comparative before-and-after design. The objective is to assess the efficacy and safety of duosomal chemical peels as agents for enhancing the aesthetic appearance of the periocular and facial regions

Timeline

Start

2023-11-01

Primary completion

2023-12-28

Completion

2024-01-31

Publications

• Results Garg VK, Sinha S, Sarkar R. Glycolic acid peels versus salicylic-mandelic acid peels in active acne vulgaris and post-acne scarring and hyperpigmentation: a comparative study. Dermatol Surg. 2009 Jan;35(1):59-65. doi: 10.1111/j.1524-4725.2008.34383.x. Epub 2008 Dec 8.
• Results Nsairat H, Khater D, Sayed U, Odeh F, Al Bawab A, Alshaer W. Liposomes: structure, composition, types, and clinical applications. Heliyon. 2022 May 13;8(5):e09394. doi: 10.1016/j.heliyon.2022.e09394. eCollection 2022 May.
• Results Lasic DD, Papahadjopoulos D. Liposomes revisited. Science. 1995 Mar 3;267(5202):1275-6. doi: 10.1126/science.7871422. No abstract available.
• Results Andra VVSNL, Pammi SVN, Bhatraju LVKP, Ruddaraju LK. A Comprehensive Review on Novel Liposomal Methodologies, Commercial Formulations, Clinical Trials and Patents. Bionanoscience. 2022;12(1):274-291. doi: 10.1007/s12668-022-00941-x. Epub 2022 Jan 26.
• Results Sarkar R, Garg V, Bansal S, Sethi S, Gupta C. Comparative Evaluation of Efficacy and Tolerability of Glycolic Acid, Salicylic Mandelic Acid, and Phytic Acid Combination Peels in Melasma. Dermatol Surg. 2016 Mar;42(3):384-91. doi: 10.1097/DSS.0000000000000642.
• Results Odrzywolek W, Deda A, Zdrada J, Wilczynski S, Blonska-Fajfrowska B, Lipka-Trawinska A. Quantitative Evaluation of the Effectiveness of Chemical Peelings in Reducing Acne Lesions Based on Gray-Level Co-Occurrence Matrix (GLCM). Clin Cosmet Investig Dermatol. 2022 Sep 12;15:1873-1882. doi: 10.2147/CCID.S375131. eCollection 2022.
• Results Grimes PE. The safety and efficacy of salicylic acid chemical peels in darker racial-ethnic groups. Dermatol Surg. 1999 Jan;25(1):18-22. doi: 10.1046/j.1524-4725.1999.08145.x.
• Results Sharquie KE, Al-Tikreety MM, Al-Mashhadani SA. Lactic acid chemical peels as a new therapeutic modality in melasma in comparison to Jessner's solution chemical peels. Dermatol Surg. 2006 Dec;32(12):1429-36. doi: 10.1111/j.1524-4725.2006.32352.x.
• Results Jarzabek-Perz S, Mucha P, Rotsztejn H. Corneometric evaluation of skin moisture after application of 10% and 30% gluconolactone. Skin Res Technol. 2021 Sep;27(5):925-930. doi: 10.1111/srt.13044. Epub 2021 Mar 26.
• Results Dayal S, Kalra KD, Sahu P. Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris. J Cosmet Dermatol. 2020 Feb;19(2):393-399. doi: 10.1111/jocd.13168. Epub 2019 Sep 25.
• Results Yamamoto K, Oishi K, Fujimatsu I, Komatsu K. Production of R-(-)-mandelic acid from mandelonitrile by Alcaligenes faecalis ATCC 8750. Appl Environ Microbiol. 1991 Oct;57(10):3028-32. doi: 10.1128/aem.57.10.3028-3032.1991.
• Results O'Connor AA, Lowe PM, Shumack S, Lim AC. Chemical peels: A review of current practice. Australas J Dermatol. 2018 Aug;59(3):171-181. doi: 10.1111/ajd.12715. Epub 2017 Oct 24.
• Results Bensimon RH. Chemical Peels. Facial Plast Surg Clin North Am. 2023 Nov;31(4):475-494. doi: 10.1016/j.fsc.2023.05.006. Epub 2023 Jul 26.
• Results Salam A, Dadzie OE, Galadari H. Chemical peeling in ethnic skin: an update. Br J Dermatol. 2013 Oct;169 Suppl 3:82-90. doi: 10.1111/bjd.12535.
• Results Gentili G, Perugini P, Bugliaro S, D'Antonio C. Efficacy and safety of a new peeling formulated with a pool of PHAs for the treatment of all skin types, even sensitive. J Cosmet Dermatol. 2023 Feb;22(2):517-528. doi: 10.1111/jocd.15215. Epub 2022 Aug 9.
• Results Roberts WE. Chemical peeling in ethnic/dark skin. Dermatol Ther. 2004;17(2):196-205. doi: 10.1111/j.1396-0296.2004.04020.x.
• Results Asilian A, Shahmoradi Z, Talakoub M, Mokhtari F, Siadat AH, Mohaghegh F, Adibi N, Mozafarpoor S, Kazemipour S, Danesh F, Hafezi H. Evaluation of combination therapy with peeling added to minimal invasive blepharoplasty in lower eyelid rejuvenation. J Cosmet Dermatol. 2020 Nov;19(11):2922-2928. doi: 10.1111/jocd.13394. Epub 2020 Apr 3.
• Results Dayan SH, Bacos JT, Ho TT, Gandhi ND, Gutierrez-Borst S, Kalbag A. Topical skin therapies in subjects undergoing full facial rejuvenation. J Cosmet Dermatol. 2019 Jun;18(3):798-805. doi: 10.1111/jocd.12977. Epub 2019 Apr 29.
• Results Eiben-Nielson C, Kerscher M. Development and validation of a global photonumeric scale for evaluating skin quality of aged female facial skin. J Cosmet Dermatol. 2021 Dec;20(12):4032-4039. doi: 10.1111/jocd.14058. Epub 2021 Mar 24.
• Results Kang MC, Lee JW, Lee TH, Subedi L, Wahedi HM, Do SG, Shin E, Moon EY, Kim SY. UP256 Inhibits Hyperpigmentation by Tyrosinase Expression/Dendrite Formation via Rho-Dependent Signaling and by Primary Cilium Formation in Melanocytes. Int J Mol Sci. 2020 Jul 28;21(15):5341. doi: 10.3390/ijms21155341.
• Results Murase D, Hachiya A, Amano Y, Ohuchi A, Kitahara T, Takema Y. The essential role of p53 in hyperpigmentation of the skin via regulation of paracrine melanogenic cytokine receptor signaling. J Biol Chem. 2009 Feb 13;284(7):4343-53. doi: 10.1074/jbc.M805570200. Epub 2008 Dec 18.
• Results Gao L, Song W, Qian L, Zhang J, Li K, Yang J, Wang G. Clinical efficacy of different therapeutic modes of CO2 fractional laser for treatment of static periocular wrinkles in Asian skin. J Cosmet Dermatol. 2022 Mar;21(3):1045-1050. doi: 10.1111/jocd.14640. Epub 2021 Dec 8.

Drugs

Indications

No indication recorded.