drugset / Trial / NCT07408609

Perioperative Chemotherapy With Low-Dose Radiotherapy and Tislelizumab for Locally Advanced Gastric or Gastroesophageal Junction Adenocarcinoma

NCT07408609 ↗

Phase 2 Not yet recruiting 114 enrolled Jiangsu Cancer Institute & Hospital
RandomizedParallel-groupOpen-labelTreatment

Summary

This study is a prospective, multicenter, randomized, phase II clinical trial enrolling patients with resectable locally advanced gastric or gastroesophageal junction adenocarcinoma. The study aims to compare the efficacy and safety of perioperative chemotherapy combined with low-dose radiotherapy and tislelizumab versus perioperative chemotherapy alone in this patient population.

Timeline

Start
2026-02-26
Primary completion
2029-02-20
Completion
2031-02-20

Drugs

EvaluationDrugModalityDoseRoute
Subject Tislelizumab Monoclonal antibody 200 mg Intravenous
Comparator Capecitabine Small molecule 1000 mg/m2 —
Comparator Oxaliplatin Small molecule 130 mg/m2 —