drugset / Trial / NCT07422558
Intravenous Nalbuphine Versus Lidocaine for Prevention of Propofol Injection Pain
RandomizedParallel-groupSingle-blindPrevention
Summary
Propofol is a commonly used intravenous anesthetic agent, but its administration is frequently associated with injection pain, causing patient discomfort and agitation. Various pharmacological agents have been used to reduce this pain, including nalbuphine and lidocaine; however, results from previous studies remain conflicting. This randomized clinical trial aims to compare the effectiveness of intravenous nalbuphine versus intravenous lidocaine in reducing the frequency of propofol-induced injection pain in patients undergoing elective general surgery procedures.
Timeline
- Start
- 2026-03-01
- Primary completion
- 2026-08-01
- Completion
- 2026-08-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Lidocaine | Other / unclassified | 4.5 mg/kg | Intravenous |
| Subject | Nalbuphine | Small molecule | 0.1 mg/kg | Intravenous |
Indications
No indication recorded.