drugset / Trial / NCT07424183
T4/T3 Therapy in Hypothyroidism
Phase 2
Not yet recruiting
60 enrolled
University of Pennsylvania
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · collab
RandomizedParallel-groupQuadruple-blindTreatment
Summary
This study will test whether 6 months of combination therapy with levothyroxine (LT4) plus liothyronine (LT3) is superior to LT4 plus placebo in participants with hypothyroidism who have residual symptoms of hypothyroidism with TSH levels within the reference range.
Timeline
- Start
- 2026-06
- Primary completion
- 2027-06
- Completion
- 2027-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Liothyronine | Small molecule | — | — |
| Background | Levothyroxine | Other / unclassified | — | — |