Effect of Nigella Sativa Toothpaste on Salivary Biomarkers in Patients With Gingivitis

Summary

This study evaluated the effects of Nigella sativa toothpaste on salivary inflammatory biomarkers (IL-1β, PGE2, and MMP-8) in Indonesian Army personnel with gingivitis. The aim was to determine whether the toothpaste could reduce inflammatory marker levels associated with gingival inflammation.

Timeline

Start

2023-01-01

Primary completion

2023-06-30

Completion

2023-07-31

Publications

• Results Maduratna E, Sari DS, Rahayu RP, Masya RN, Adinar N. The Anti-Inflammatory Effect of Nigella sativa Toothpaste on Porphyromonas gingivalis Bacteria Through Decreased TNF-alpha, MMP-9, PGE-2 Expression in Wistar Rats. Eur J Dent. 2024 Jul;18(3):808-814. doi: 10.1055/s-0043-1772700. Epub 2024 May 14.

Drugs

Indications