drugset / Trial / NCT07452588
Effect of Sodium Chloride 5% Solution as an Adjuvant Treatment With Antimicrobial Therapy in the Treatment of Bacterial Infectious Keratitis
RandomizedParallel-groupOpen-labelTreatment
Summary
This study aims to detect the effect of sodium chloride 5% solution as an adjuvant treatment with antimicrobial therapy in treatment of bacterial infectious keratits and to assess whether NaCl 5% accelerates epithelial healing, improves microbial eradication, and enhances visual outcomes in bacterial infectious keratitis.
Timeline
- Start
- 2026-02
- Primary completion
- 2026-08
- Completion
- 2027-02
Publications
- Background 9. Davidson, P.; Taylor, T. Chemical Preservatives and Natural Antimicrobial Compounds. In Food Microbiology: Fundamentals and Frontiers, 3rd ed.; Wiley Online Library: New York, NY, USA, 2017; pp. 713-745
- Background Acharya M, Farooqui JH, Jain S, Mathur U. Pearls and paradigms in Infective Keratitis. Rom J Ophthalmol. 2019 Apr-Jun;63(2):119-127.
- Background Ung L, Bispo PJM, Shanbhag SS, Gilmore MS, Chodosh J. The persistent dilemma of microbial keratitis: Global burden, diagnosis, and antimicrobial resistance. Surv Ophthalmol. 2019 May-Jun;64(3):255-271. doi: 10.1016/j.survophthal.2018.12.003. Epub 2018 Dec 24.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | sodium chloride | Unknown | 5 % | — |