drugset / Trial / NCT07476898
Precision Reperfusion Therapy for Disabling Minor Stroke With Large Vessel Occlusion Beyond Time Window
RandomizedParallel-groupOpen-labelTreatment
Summary
To verify the efficacy and safety of intravenous tenecteplase (TNK) in patients with disabling minor stroke and large vessel occlusion (LVO) within a 4.5-24 hour time window.
Timeline
- Start
- 2026-03-01
- Primary completion
- 2028-07-01
- Completion
- 2028-08-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Aspirin | Small molecule | 100 mg | Oral |
| Comparator | Clopidogrel | Small molecule | 75 mg | Oral |
| Subject | Tenecteplase | Protein / enzyme biologic | 0.25 mg/kg | Intravenous |
| Comparator | Ticagrelor | Small molecule | 90 mg | Oral |