drugset / Trial / NCT07491718

Manganese-enhanced Magnetic Resonance Imaging in Takotsubo Cardiomyopathy

NCT07491718

Recruiting 100 enrolled University of Edinburgh
RandomizedCrossoverOpen-labelOther

Summary

The goal of this research study is to further understand the physiological mechanisms involved in a heart condition called takotsubo cardiomyopathy, also known as broken heart syndrome. Furthermore, the investigators will be assessing the effects different cardiac medications have on these physiological mechanisms. This will be achieved by performing cardiac MRI scans using a special dye called manganese. Manganese uptake in the heart is altered in patients with takotsubo cardiomyopathy. The investigators will study the effects that different cardiac medications have on manganese uptake.

Timeline

Start
2025-08-08
Primary completion
2028-08-09
Completion
2028-08-09

Drugs

EvaluationDrugModalityDoseRoute
Comparator Bisoprolol Other / unclassified
Comparator Dapagliflozin Small molecule 10 mg
Subject Sacubitril/Valsartan Unknown
Comparator Valsartan Small molecule