Anrikefon-based Patient-controlled Intravenous Analgesia Following Laparoscopic Surgery

Summary

Visceral pain following laparoscopic surgery is frequently underestimated, yet it is associated with a range of adverse outcomes. Effective visceral pain management should constitute an essential component of postoperative analgesic strategies following laparoscopic procedures. However, conventional analgesic agents, including μ-opioid receptor agonists, lack specificity for visceral pain. Anrikefon, a novel selective peripheral κ-opioid receptor agonist, demonstrates unique efficacy in alleviating visceral pain with a favorable safety profile. Preliminary studies showed that a single intravenous dose of anrikefon effectively alleviates postoperative pain after abdominal surgery with a low risk of adverse effects. The investigators hypothesize that an appropriate dosing regimen of anrikefon administered via patient-controlled intravenous analgesia (PCIA) pump, as part of a multimodal analgesic strategy, can specifically target and alleviate visceral pain after laparoscopic surgery, thereby achieving comprehensive postoperative analgesia.

Timeline

Start

2026-04-14

Primary completion

2027-03

Completion

2027-04

Publications

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• Background Cheong JY, Keshava A, Witting P, Young CJ. Effects of Intraoperative Insufflation With Warmed, Humidified CO2 during Abdominal Surgery: A Review. Ann Coloproctol. 2018 Jun;34(3):125-137. doi: 10.3393/ac.2017.09.26. Epub 2018 Jun 30.
• Background de Lacy FB, Taura P, Arroyave MC, Trepanier JS, Rios J, Bravo R, Ibarzabal A, Pena R, Deulofeu R, Lacy AM. Impact of pneumoperitoneum on intra-abdominal microcirculation blood flow: an experimental randomized controlled study of two insufflator models during transanal total mesorectal excision : An experimental randomized multi-arm trial with parallel treatment design. Surg Endosc. 2020 Oct;34(10):4494-4503. doi: 10.1007/s00464-019-07236-5. Epub 2019 Nov 7.
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• Background Armstrong RA, Fayaz A, Manning GLP, Moonesinghe SR; Peri-operative Quality Improvement Programme (PQIP) delivery team; Oliver CM; PQIP collaborative. Predicting severe pain after major surgery: a secondary analysis of the Peri-operative Quality Improvement Programme (PQIP) dataset. Anaesthesia. 2023 Jul;78(7):840-852. doi: 10.1111/anae.15984. Epub 2023 Mar 2.
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Drugs

Indications

No indication recorded.