drugset / Trial / NCT07548489

Phenobarbital for Agitated Delirium

NCT07548489

Phase 3 Not yet recruiting 150 enrolled Duke University
RandomizedSequentialOpen-labelTreatment

Summary

The goal of this clinical trial is to test whether the medication phenobarbital is as effective for treating agitated delirium among adult patients admitted to the intensive care unit. Agitated delirium is a condition involving confusion and impulsiveness which is dangerous to both patients and healthcare providers. The main questions this trial aims to answer include: * Can phenobarbital decrease the amount of time patients with agitated delirium spend in the intensive care unit and the hospital? * Does phenobarbital decrease the amount of additional calming medications patients with agitated delirium need? Researchers in this study will compare phenobarbital to other medications commonly used to treat agitated delirium. Participants will be monitored closely to make sure they remain safe and to measure how well their agitation and confusion are managed while they are in the ICU.

Timeline

Start
2026-06
Primary completion
2027-01
Completion
2027-07

Drugs

EvaluationDrugModalityDoseRoute
Subject Phenobarbital Unknown

Indications