Drugs / Phenobarbital

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) SEZABY 2022-11-17 fda.gov

Trials 15 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT00002759 Jun 1996 → Apr 2002 lymphoma, neutropenia, poisoning, small intestine cancer National Cancer Institute (NCI) Completed No outcome recorded
Phase 21 trial
Phase 2 NCT03025906 Feb 2017 → Oct 2019 epilepsy with generalized tonic-clonic seizures Xuanwu Hospital, Beijing Unknown No outcome recorded
Phase 36 trials
Phase 3 NCT07548489 Jun 2026 → Jan 2027 expected delirium Duke University Not yet recruiting No outcome recorded
Phase 3 NCT03650270 Mar 2015 → Mar 2018 epilepsy University of Cape Town Completed No outcome recorded
Phase 3 NCT02374567 Jan 2015 → Jun 2017 anxiety disorder, dementia, depressive disorder, schizophrenia +1 Hannover Medical School Terminated No outcome recorded
Phase 3 NCT01284556 Nov 2010 → Jan 2013 epilepsy West-Ward Pharmaceutical Completed No outcome recorded
Phase 3 NCT02810782 Jun 2001 → Dec 2007 neonatal abstinence syndrome University of Zurich Completed No outcome recorded
Phase 3 NCT00009620 Feb 1993 → Feb 1995 fetal growth restriction, intracerebral hemorrhage NICHD Neonatal Research Network Completed No outcome recorded
Phase 41 trial
Phase 4 NCT06081283 Nov 2023 → Dec 2024 brain hypoxia - ischemia, cardiac arrest, intracerebral hemorrhage, traumatic brain injury University of North Carolina, Chapel Hill Terminated No outcome recorded
Phase not applicable6 trials
NCT03586089 Jun 2021 → Jul 2023 alcohol withdrawal delirium Unity Health Toronto Terminated No outcome recorded
NCT05236166 Apr 2017 → May 2021 epilepsy University Magna Graecia Completed No outcome recorded
NCT01224457 May 2008 → Apr 2010 neonatal epilepsy syndrome Yonsei University Completed No outcome recorded
NCT00530413 Mar 2007 → Mar 2009 epilepsy University of Toledo Health Science Campus Withdrawn No outcome recorded
NCT00435994 Dec 2003 → Mar 2009 bronchiolitis, respiratory syncytial virus infectious disease Indiana University Completed No outcome recorded
NCT00381537 epilepsy Institute of Child Health Completed No outcome recorded
Also used as a comparator or background therapy in 23 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT00734864 Background Jun 2009 → Jun 2010 anaplastic astrocytoma, anaplastic oligodendroglioma, gliosarcoma Annick Desjardins Withdrawn No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT02550028 Comparator Sep 2015 → Jan 2017 neonatal epilepsy syndrome Children's Hospital of Fudan University Terminated No outcome recorded
Phase 1/2 NCT01720667 Comparator Mar 2013 → Oct 2017 neonatal epilepsy syndrome Richard H. Haas Completed No outcome recorded
Phase 22 trials
Phase 2 NCT05610085 Comparator Mar 2023 → Jul 2027 expected brain hypoxia - ischemia, neonatal epilepsy syndrome University of California, San Diego Recruiting No outcome recorded
Phase 2 NCT03670160 Comparator Oct 2018 → May 2020 neonatal abstinence syndrome University of Tennessee Medical Center Completed No outcome recorded
Phase 37 trials
Phase 3 NCT05346666 Background Jun 2022 → Sep 2023 epilepsy Damanhour University Unknown No outcome recorded
Phase 3 NCT05291455 Comparator Mar 2022 → Mar 2024 epilepsy Tanta University Unknown No outcome recorded
Phase 3 NCT04320940 Comparator Mar 2021 → Feb 2023 benign neonatal seizures NEMA Research, Inc. Terminated No outcome recorded
Phase 3 NCT03602118 Comparator Nov 2019 → May 2021 neonatal epilepsy syndrome PharPoint Research, Inc. Withdrawn No outcome recorded
Phase 3 NCT02726867 Comparator Feb 2014 → Nov 2016 epilepsy Mid-Atlantic Epilepsy and Sleep Center, LLC Withdrawn No outcome recorded
Phase 46 trials
Phase 4 NCT07284498 Comparator Jan → Sep 2026 expected brain hypoxia - ischemia, neonatal epilepsy syndrome Mansoura University Not yet recruiting No outcome recorded
Phase 4 NCT04156464 Comparator Jul 2020 → Dec 2021 alcohol withdrawal delirium OSF Healthcare System Unknown No outcome recorded
Phase 4 NCT03788889 Comparator Apr 2019 alcohol withdrawal Santa Barbara Cottage Hospital Withdrawn No outcome recorded
Phase 4 NCT03107507 Comparator Mar → Oct 2017 neonatal epilepsy syndrome Cairo University Unknown No outcome recorded
Phase 4 NCT01089504 Comparator Sep 2010 → Nov 2014 neonatal epilepsy syndrome University of Rochester Terminated No outcome recorded
Phase not applicable5 trials
NCT07098728 Comparator Jul 2025 → Mar 2026 overdue epilepsy Ministry of Health and Sports, Myanmar Recruiting No outcome recorded
NCT07401433 Comparator Apr 2024 → Mar 2025 neonatal epilepsy syndrome Hayat Abad Medical Complex, Peshawar Completed No outcome recorded
NCT03636958 Background Feb 2021 → Jul 2025 epilepsy Assistance Publique Hopitaux De Marseille Withdrawn No outcome recorded
NCT01175668 Comparator Jul 2010 → Aug 2012 neonatal abstinence syndrome Baystate Medical Center Terminated No outcome recorded
NCT01184417 Comparator Jan 2009 → Mar 2010 alcohol withdrawal Jonathan Rosenson Completed No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 38 sources stand behind the page.

FieldValueCited text
Known as Phenobarbital “Drugs from ACT groups N03A, N05BA, N05CD, H02A or S01EC will be used including prednisolon,levetiracetam, valproate, carbamazepine, oxcarbazepine, topiramate, felbamate,...” NCT00552526
35

“Antiepileptic drugs allowed are therefore: lamotrigine, levetiracetam, lacosamide, sodium valproate, carbamazepine, oxcarbabazepine, slicarbazepine, pregabalin, gabapentin,...” NCT03636958

“List of allowed antiepileptic drugs were: valporic acid, carbamazepine, clobazam, N-desmethylclobazam, topiramate,TRI477, TRI476, clonazepam, zonisamide, phenobarbital, phenytoin” NCT01713946

“Drugs: carbamazepine, lamotrigine, levetiracetam, oxcarbazepine, phenobarbital, phenytoin, topiramate, valproic acid, zonisamide” NCT05236166

“Phenytoin/Dilantin, Fosphenytoin/Cerebyx, Phenobarbital, Primidone/Mysoline” NCT00734864

NCT01175668

NCT03025906

NCT02550028

NCT07284498

NCT03650270

NCT00002759

NCT05291455

NCT01224457

NCT01958476

NCT07548489

NCT02810782

NCT05610085

NCT03788889

NCT04320940

NCT06081283

NCT03107507

NCT07401433

NCT02374567

NCT02726867

NCT01284556

NCT00530413

NCT04156464

NCT05346666

NCT01720667

NCT03602118

NCT01089504

NCT07098728

NCT03670160

NCT01184417

NCT00009620

NCT03586089

Known as Phenobarbital Sodium Phenobarbital Sodium Injection” NCT05610085
Known as Phenobarbital Sodium Injection “Participants will receive either a 20-mg/kg or 40-mg/kg loading dose of Phenobarbital Sodium Injection, USP upon confirmation that the seizure was not due to metabolic imbalances.” NCT03602118
Known as Phenobarbitone Phenobarbitone will be administered intravenously as the first-line anticonvulsant for neonatal seizures.” NCT07401433
1

NCT00381537

Known as primatene ClinicalTrials.gov intervention name — accepted as the source's own label NCT00435994
Action Activate “GABAR-enhancing agent Phenobarbital” NCT00530413
Route Oral “Patients receive oral phenobarbital, cyclosporine as in part I, and irinotecan at the MTD from part I.” NCT00002759