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drugset / Trial / NCT07570927

Salivary Microbiota and Antimicrobial Resistance in Relation to Chlorhexidine Use

NCT07570927 ↗

Completed 11 enrolled Masaryk University
NaSingle-groupOpen-labelHealth-services research

Summary

This study evaluated the ecological effects of 0.06% chlorhexidine toothpaste on the salivary microbiota of healthy individuals, focusing on taxonomic composition, functional shifts, and prevalence of predicted antimicrobial resistance genes. Saliva samples were collected from eleven healthy participants at three specific time points: baseline (following a 4-week run-in period using a control toothpaste), intervention (after 12 weeks of using 0.06% chlorhexidine digluconate toothpaste), and washout (after a subsequent 12-week period using the control toothpaste). Sequencing targeted the 16S rRNA V3-V4 region.

Timeline

Start
2022-04-11
Primary completion
2022-11-29
Completion
2022-11-29

Drugs

EvaluationDrugModalityDoseRoute
Subject Chlorhexidine Small molecule 0.06 % —

Indications

No indication recorded.