Repetitive GON Blockade for Menstrual Migraine

Summary

: The primary objective of this prospective, randomized, double-blind, placebo-controlled clinical trial is to evaluate whether repetitive bilateral greater occipital nerve (GON) blockade administered with a local anesthetic (0.5% bupivacaine) significantly reduces headache severity, attack duration, and the number of pain days in female patients with menstrual migraine compared to a placebo group (normal saline). Patients will receive injections twice a month for three months (seven days before the expected onset of menstruation and on the first day of menstruation).

Timeline

Start

2024-10-19

Primary completion

2025-05-30

Completion

2025-11-30

Publications

• Background Cetin G, Totuk O, Cetin OE, Demir S, Sahin S. Evaluation of the effectiveness of greater occipital nerve blockade in menstrual migraine. BMC Neurol. 2025 Feb 13;25(1):62. doi: 10.1186/s12883-025-04070-2.

Drugs

Indications