drugset / Trial / NCT07576543
Long-term Follow-up of Dexmedetomidine-esketamine and tDCS for Neurocognitive Complications After Surgery
Phase 4
Not yet recruiting
1160 enrolled
Peking University First Hospital
Fujian Medical University Union Hospital · collabPeking University Shenzhen Hospital · collabSecond Affiliated Hospital, School of Medicine, Zhejiang University · collabThe First Affiliated Hospital of Air Force Medicial University · collabZhejiang University · collab
RandomizedFactorialQuadruple-blindPrevention
Summary
Neurocognitive complications, mainly delirium and neurocognitive disorders, are common cerebral complications in older patients after surgery and associated with worse long-term outcomes. An ongoing 2×2 factorial trial conducted by the investigators plan to test the effects of perioperative dexmedetomidine-esketamine combination and transcranial direct current stimulation (tDCS) on postoperative neurocognitive complications in older patients. This long-term follow-up of the ongoing trial aims to investigate the effects of perioperative dexmedetomidine-esketamine combination and tDCS on long-term outcomes in older patients after noncardiac surgery.
Timeline
- Start
- 2026-06
- Primary completion
- 2030-06
- Completion
- 2031-06
Publications
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Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dexmedetomidine | Other / unclassified | 0.1 ug/kg | — |
| Subject | Esketamine | Other / unclassified | 0.05 mg/kg | — |