drugset / Trial / NCT07622771

Neoadjuvant Radiotherapy Combined With NALIRIFOX and Adebrelimab in pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Randomized, Phase II Clinical Trial

NCT07622771

Phase 2 Not yet recruiting 84 enrolled Sun Yat-sen University
RandomizedParallel-groupOpen-labelTreatment

Summary

To explore the efficacy and safety of radiotherapy combined with Adebrelimab and NALIRIFOX in patients with pMMR/MSS locally advanced rectal cancer

Timeline

Start
2026-06-01
Primary completion
2028-06-30
Completion
2032-12-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Capecitabine Small molecule 825 mg/m2
Background Adalimumab Monoclonal antibody 200 mg/m2
Background Adalimumab Monoclonal antibody 1200 mg
Background Irinotecan Small molecule 60 mg/m2
Background Oxaliplatin Small molecule 85 mg/m2
Background fluorouracil Small molecule 2400 mg/m2

Indications