Fascia Iliaca Block Using Liposomal Bupivacaine for Analgesia After Hip Fracture Surgery

Phase 4 Not yet recruiting 148 enrolled Peking University First Hospital

RandomizedParallel-groupTriple-blindTreatment

Summary

Older patients with hip fractures often suffer from severe pain. Inadequate analgesia increases the risk of postoperative delirium, myocardial injury, and other complications. Peripheral nerve block is an important component of multimodal analgesia, but conventional local anesthetics (such as plain bupivacaine) provide only approximately 12 hours of analgesic duration, which is far from covering the most painful 72 hours after surgery. Liposomal bupivacaine has a slow-release property, prolonging the analgesic duration up to 72 hours after a single injection. However, its clinical advantages in hip fracture surgery remain controversial. The investigators suppose that, compared with plain bupivacaine alone, preoperative supra-inguinal fascia iliaca block using liposomal bupivacaine combined with plain bupivacaine can further improve analgesia, decrease opioid consumption, and improve postoperative recovery quality within 72 hours in older patients after hip fracture surgery.

Timeline

Start: 2026-07
Primary completion: 2028-06
Completion: 2028-08

Publications

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Bupivacaine	Other / unclassified	150 mg	Other
Comparator	Bupivacaine	Other / unclassified	266 mg	Other

Indications

No indication recorded.