drugset / Trial / NCT07684612

A Study to Investigate Mocertatug Rezetecan With Bevacizumab Compared With Platinum Doublet With Bevacizumab in Participants With Platinum-sensitive Ovarian Cancer (BEHOLD-Ovarian02)

NCT07684612

Phase 3 Not yet recruiting 690 enrolled GlaxoSmithKline GOG, ENGOT, APGOT · collab
RandomizedParallel-groupSingle-blindTreatment

Summary

This study specifically aims to evaluate how well mocertatug rezetecan (Mo-Rez) in combination with bevacizumab works in treating platinum-sensitive ovarian cancer compared to standard treatments by checking whether it makes cancers smaller or disappear completely and if it helps participants live longer. The study also assesses whether Mo-Rez in combination with bevacizumab is safe and tolerated well by participants compared to standard treatments and aims to provide a better understanding of the main side effects of Mo-Rez.

Timeline

Start
2026-09-22
Primary completion
2030-05-21
Completion
2033-04-22

Drugs

EvaluationDrugModalityDoseRoute
Subject Bevacizumab Monoclonal antibody
Comparator Carboplatin Small molecule
Comparator Doxorubicin Other / unclassified
Comparator Gemcitabine Small molecule
Subject Mocertatug rezetecan Unknown
Comparator Paclitaxel Small molecule

Indications