drugset / Trial / NCT07686055
Precision Management of Urinary Tract Symptoms in Older Women
Phase 3
Not yet recruiting
90 enrolled
Megan Bradley
American Association of Obstetricians and Gynecologists Foundation (AAOGF) · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
This project aims to improve the diagnosis and management of urinary tract symptoms in older women by comparing three common treatment strategies-empiric antibiotics, urinalysis-guided therapy, and culture-directed care-in a randomized trial. By integrating patient-reported outcomes, laboratory data, the study will identify which patients benefit from antibiotics and which can safely avoid them. Findings will inform precision care strategies and promote antibiotic stewardship while improving symptom outcomes and quality of life in this high-risk population.
Timeline
- Start
- 2026-07-14
- Primary completion
- 2027-02-01
- Completion
- 2027-02-14
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | CEPHALEXIN ANHYDROUS | Small molecule | 500 mg | Oral |
| Subject | Ciprofloxacin | Small molecule | 250 mg | Oral |
| Subject | Fosfomycin | Small molecule | 3 g | Oral |
| Subject | Nitrofurantoin | Unknown | 100 mg | Oral |
| Subject | trimethoprim/sulfamethoxazole | Unknown | 125 mg | Oral |
| Subject | trimethoprim/sulfamethoxazole | Unknown | 875 mg | Oral |