drugset / Trial / NCT07711132
Remineralizing Effect of Nano-eggshell, Casein Phosphopeptide Amorphous Calcium Phosphate (CPP-ACP), and Sodium Fluoride on Initial Enamel Caries
RandomizedParallel-groupSingle-blindTreatment
Summary
This randomized controlled clinical trial aims to evaluate and compare the remineralizing effect of nano-eggshell varnish, CPP-ACP paste (GC Tooth Mousse), and sodium fluoride varnish on initial enamel caries among adolescents aged 15-20 years. Participants will be randomly allocated into three groups. Remineralization and caries activity will be assessed using DIAGNOdent readings, International Caries Classification and Management System (ICCMS) criteria, and the decayed, missed, and filled surfaces (DMFS) index over a 12-month follow-up period.
Timeline
- Start
- 2025-12-20
- Primary completion
- 2026-12-20
- Completion
- 2026-12-20
Publications
- Background Sarhan M, El Baz M, Hamza O. Remineralization effect of eggshell powder on post-orthodontic white spot lesions compared to CPP-ACP: a randomized controlled clinical trial. Egyptian Dental Journal. 2021. 67(3): 2701-2710.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) | Unknown | — | Topical |
| Subject | nano-eggshell | Unknown | — | Topical |
| Comparator | sodium fluoride | Unknown | 5 % | Topical |