Effects of Estrogen Therapy on Lipid Metabolism and Insulin Sensitivity in Hypogonadal Women

Summary

This study aims to evaluate the short-term effects of estrogen therapy on lipid metabolism and insulin sensitivity in hypogonadal women. Participants receiving estrogen therapy will be assessed before initiation of treatment and after the treatment period to determine changes in serum estrogen levels, fasting glucose, fasting insulin, and lipid profile. Insulin sensitivity will be assessed using the HOMA-IR index. The findings may contribute to a better understanding of the short-term metabolic effects of estrogen therapy in women with hypogonadism.

Timeline

Start

2025-12-04

Primary completion

2026-07-09

Completion

2026-09-20

Publications

• Background Tebbens M, Schutte M, Troelstra MA, Bruinstroop E, de Mutsert R, Nederveen AJ, den Heijer M, Bisschop PH. Sex Steroids Regulate Liver Fat Content and Body Fat Distribution in Both Men and Women: A Study in Transgender Persons. J Clin Endocrinol Metab. 2023 Dec 21;109(1):e280-e290. doi: 10.1210/clinem/dgad409.
• Background Dam TV, Dalgaard LB, Thomsen CB, Hjortebjerg R, Ringgaard S, Johansen FT, Bengtsen MB, Mose M, Lauritsen KM, Sondergaard E, Gravholt CH, Hansen M. Estrogen modulates metabolic risk profile after resistance training in early postmenopausal women: a randomized controlled trial. Menopause. 2021 Nov 1;28(11):1214-1224. doi: 10.1097/GME.0000000000001841.
• Background Huang L, Wang H, Shi M, Kong W, Jiang M. Lipid Profile in Patients With Primary Ovarian Insufficiency: A Systematic Review and Meta-Analysis. Front Endocrinol (Lausanne). 2022 Jun 10;13:876775. doi: 10.3389/fendo.2022.876775. eCollection 2022.

Drugs

Indications