drugset / Trial / NCT07825064

Cevostamab in Combination With Pomalidomide and Dexamethasone After BCMA- Targeting CAR T-Cell Therapy in Participants With Previously Treated Multiple Myeloma

NCT07825064 ↗

Phase 2 Recruiting 45 enrolled Hoffmann-La Roche
NaSingle-groupOpen-labelTreatment

Summary

The purpose of this study is to assess the efficacy and safety of cevostamab in combination with pomalidomide and dexamethasone (CevosPd) in patients with multiple myeloma (MM) who have received one to four prior lines of therapy and have been exposed to an anti-cluster of differentiation 38 (CD38) antibody, lenalidomide, a proteasome inhibitor (PI) and a B cell maturation antigen (BCMA)-targeting chimeric antigen receptor (CAR) T-cell therapy.

Timeline

Start
2026-10-01
Primary completion
2029-04-13
Completion
2031-01-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Cevostamab Monoclonal antibody — —
Subject Pomalidomide Other / unclassified — —
Background Dexamethasone Small molecule — —
Background Tocilizumab Monoclonal antibody — —

Indications