drugset / Trial / NCT07843550

A Phase 1/2 Trial Of Larotrectinib And Pembrolizumab In Patients With Solid Tumors Previously Treated With Immune Checkpoint Inhibitor Monotherapy

NCT07843550 ↗

Phase 1/2 Not yet recruiting 22 enrolled M.D. Anderson Cancer Center
NaSingle-groupOpen-labelTreatment

Summary

This is a single-center, open-label Phase 1/2 trial evaluating the safety and efficacy of the combination of larotrectinib and pembrolizumab in patients with advanced/metastatic lung adenocarcinoma or melanoma.

Timeline

Start
2027-03-01
Primary completion
2027-07-13
Completion
2029-07-13

Drugs

EvaluationDrugModalityDoseRoute
Subject Larotrectinib Small molecule — —
Subject Pembrolizumab Monoclonal antibody — Intravenous

Indications