Drugs / Enlicitide
last change Jul 2026 re-read 2 minutes ago

Enlicitide

also known as Enlicitide Chloride · MK-0616

targets PCSK9 via inhibition

Developed for
hyperlipidemia · familial hypercholesterolemia · lipoprotein, variant of beta
Investigated by
Merck Sharp & Dohme LLC · Celerion

Trials 18 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 114 trials
Phase 1 NCT07619443 Jul → Sep 2026 expected Merck Sharp & Dohme LLC Recruiting No outcome recorded
Phase 1 NCT07481708 Mar → May 2026 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT07300280 Dec 2025 → Oct 2026 expected Merck Sharp & Dohme LLC Recruiting No outcome recorded
Phase 1 NCT07044479 Jul → Aug 2025 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06880874 Apr → May 2025 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06719544 Jan 2025 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06643377 Nov 2024 → Jun 2025 impaired renal function disease Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06609512 Oct 2024 → Jan 2025 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06597760 Oct → Nov 2024 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06575959 Sep 2024 → May 2025 liver disorder Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 21 trial
Phase 2 NCT07614984 Jun 2026 → Oct 2027 expected lipoprotein, variant of beta Merck Sharp & Dohme LLC Recruiting No outcome recorded
Phase 33 trials
Phase 3 NCT07216482 Nov 2025 → Dec 2026 expected hyperlipidemia Merck Sharp & Dohme LLC Active not recruiting No outcome recorded
Phase 3 NCT06450366 Jul 2024 → Feb 2025 hyperlipidemia Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT05952869 Aug 2023 → Apr 2025 familial hypercholesterolemia Merck Sharp & Dohme LLC Completed No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 19 sources stand behind the page.

FieldValueCited text
Known as Enlicitide ClinicalTrials.gov intervention name — accepted as the source's own label NCT07614984
13

NCT07481708

NCT07216482

NCT06609512

NCT05952869

NCT06719544

NCT07300280

NCT06575959

NCT06880874

NCT07044479

NCT06597760

NCT06450366

NCT07619443

NCT06643377

Known as Enlicitide Chloride ClinicalTrials.gov intervention name — accepted as the source's own label NCT06655311
3

NCT05070390

NCT06658626

NCT06814106

Known as MK-0616 “A Study of Enlicitide Chloride (MK-0616) in Healthy Participants and Participants Taking Statins (MK-0616-012)” NCT06655311
1

“enlicitide (MK-0616)” NCT07481708

Action Inhibit “an oral proprotein convertase subtilisin/kexin type 9 inhibitor” PMID 41206969 Jan 2026
Route Oral “Participants received 20 mg of enlicitide decanoate orally once daily (QD) for up to 52 weeks.” NCT05952869
Target PCSK9 “an oral proprotein convertase subtilisin/kexin type 9 inhibitor” PMID 41206969 Jan 2026