Drugs / Silver Sulfadiazine
Silver Sulfadiazine
also known as
silver sulphadiazine · SILVADENE · Flamazine · flammazine · Silvadene Topical Product · SSD · Sulfadiazine Silver
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | SILVADENE | — | 1973-11-26 | fda.gov ↗ |
Trials 7
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 22 trials | ||||||
| Phase 2 | NCT03574935 | Jul 2018 → Sep 2019 | ulcer disease | Shanghai Yueyang Integrated Medicine Hospital | Unknown | No outcome recorded |
| Phase 2 | NCT00332163 | Apr 2006 → Jan 2008 | colorectal cancer, exanthem, toxic dermatosis | Amgen | Completed | No outcome recorded |
| Phase 2/31 trial | ||||||
| Phase 2/3 | NCT01553708 | Dec 2011 → May 2012 | — | Chulalongkorn University | Completed | No outcome recorded |
| Phase 31 trial | ||||||
| Phase 3 | NCT01017094 | Sep 2007 → Jun 2008 | bone disorder | Prince of Songkla University | Completed | No outcome recorded |
| Phase 42 trials | ||||||
| Phase 4 | NCT01926392 | Apr → Oct 2011 | — | University of Virginia | Completed | No outcome recorded |
| Phase 4 | NCT00156988 | Mar 2004 → Dec 2005 | — | Association of Dutch Burn Centres | Completed | No outcome recorded |
| Phase not applicable1 trial | ||||||
| — | NCT04277182 | Sep 2020 | — | Izmir Katip Celebi University | Completed | No outcome recorded |
| Comparator or background therapy22 trials | ||||||
| Phase 0 | NCT02099240 Comparator | Mar 2014 → Nov 2018 | osteomyelitis | University of Louisville | Terminated | No outcome recorded Stop: Enrollment |
| Phase 1/2 | NCT02116010 Comparator | Jul 2015 → Jul 2016 | skin infection | Phagenix | Unknown | No outcome recorded |
| Phase 2 | NCT01297400 Comparator | Mar 2022 → Dec 2026 expected | — | Skingenix, Inc. | Recruiting | No outcome recorded |
| Phase 2 | NCT03162367 Comparator | Apr 2019 → Mar 2020 | — | SCARM Institute, Tabriz, Iran | Completed | Met primary |
| Phase 2 | NCT04391582 Comparator | May 2017 → Apr 2018 | — | Drug Research and Development Center, Federal University of Ceara | Completed | No outcome recorded |
| Phase 2 | NCT03592498 Comparator | Oct 2016 → Sep 2017 | — | Drug Research and Development Center, Federal University of Ceara | Completed | No outcome recorded |
| Phase 3 | NCT03791710 Comparator | Mar 2019 → Jan 2020 | — | Ahmed Mohamed Abouzaid | Completed | No outcome recorded |
| Phase 3 | NCT04202289 Comparator | Apr 2017 → Oct 2018 | — | Drug Research and Development Center, Federal University of Ceara | Completed | No outcome recorded |
| Phase 3 | NCT02109718 Comparator | Jan 2009 → Jul 2010 | — | University of the Philippines | Completed | Missed primary |
| Phase 4 | NCT06872151 Comparator | Mar 2025 | anus disorder, hemorrhoid | University of Cagliari | Completed | No outcome recorded |
| Phase 4 | NCT04601532 Comparator | Jun 2021 → Dec 2022 | — | J. Peter Rubin, MD | Terminated | No outcome recorded Stop: Enrollment |
| Phase 4 | NCT02108535 Comparator | Nov 2013 → Aug 2014 | — | University of Sorocaba | Completed | Missed primary |
| Phase 4 | NCT00634166 Background | Sep 2007 → Dec 2013 | — | Mylan Inc. | Terminated | No outcome recorded |
| Phase 4 | NCT00297752 Comparator | Mar 2006 → Dec 2008 | — | Association of Dutch Burn Centres | Completed | No outcome recorded |
| — | NCT07367087 Comparator | Feb → Aug 2026 overdue | — | Nishtar Medical University | Not yet recruiting | No outcome recorded |
| — | NCT05073172 Comparator | Jan → Dec 2024 | breast carcinoma, head and neck carcinoma, radiodermatitis | OHSU Knight Cancer Institute | Withdrawn | No outcome recorded |
| — | NCT05877638 Comparator | Mar 2023 → Jun 2024 | — | Synedgen, Inc. | Terminated | No outcome recorded Stop: Enrollment |
| — | NCT02497326 Comparator | Apr → Dec 2015 | — | King Edward Medical University | Unknown | No outcome recorded |
| — | NCT01598480 Comparator | May 2012 → Mar 2014 | — | Bio-medical Carbon Technology Co., Ltd. | Completed | No outcome recorded |
| — | NCT01598493 Comparator | May 2012 → Mar 2014 | — | Bio-medical Carbon Technology Co., Ltd. | Completed | No outcome recorded |
| — | NCT01439074 Comparator | Sep 2011 → Sep 2013 | — | Molnlycke Health Care AB | Completed | No outcome recorded |
| — | NCT00641433 Comparator | Nov 2005 → May 2008 | — | Rosalind Franklin University of Medicine and Science | Unknown | No outcome recorded |
Evidence & citations 10 cited values
Every value below carries the sentence it was read from. 30 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | silversulfadiazine | “'Topical Antimicrobial/Antifungal Medications' Various topical antimicrobials and antifungals include: Bacitracin; Amphotericin B; Silver Sulfadiazine; Cefazolin; Vancomycin;...” NCT00634166 ↗24“This multicenter, randomized, controlled trial thus investigates the effectiveness of cerium nitrate-silver sulfadiazine in the treatment of facial burns compared with silver...” PMID 22842424 ↗ Aug 2012 “Application of silver sulfadiazine ointment, bandage covered with gauze and bandage.” NCT03592498 ↗ “1% Silver Sulfadiazine will be applied topically to rats for 21 days.” NCT04277182 ↗ “topical medical treatment (eg, silver sulfadiazine, Silvadene)” NCT00332163 ↗ “silversulfadiazine (flammazine)” NCT00297752 ↗ “Silver sulfadiazine cream” NCT01598493 ↗ “Silver Sulfadiazine” NCT02099240 ↗ |
| Known as | Flamazine | ClinicalTrials.gov intervention name — accepted as the source's own label NCT01598480 ↗ |
| Known as | flammazine | “silversulfadiazine (flammazine)” NCT00297752 ↗ |
| Known as | SILVADENE | “SILVADENE Cream 1% (silver sulfadiazine) is a topical antimicrobial drug indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and...” NCT05877638 ↗1“Silvadene® Cream 1% [Silver Sulfadiazine]” NCT01297400 ↗ |
| Known as | Silvadene Topical Product | “Silvadene Topical Product” NCT04601532 ↗ |
| Known as | silver sulphadiazine | “Polyfax skin ointment plus Lignocain gel will be applied on superficial PTB area and silver sulphadiazine cream on deep PTB in morning and evening after wound wash” NCT02497326 ↗ |
| Known as | SSD | “silver sulfadiazine (SSD) 1% cream” NCT01439074 ↗ |
| Known as | Sulfadiazine Silver | “2.1% Sulfadiazine Silver Cream（lesions with infection）” NCT03574935 ↗ |
| Modality | Small molecule | “Silver sulfadiazine, a sulfa drug, is used to prevent and treat infections in burn wounds.” NCT04601532 ↗ |
| Route | Topical | “topical silver sulfadiazine cream” NCT00641433 ↗ |