Drugs / Perifosine
last change Feb 2021 re-read 2 minutes ago

Perifosine

also known as AEZS-104 · D-21226 · D-21266 · KRX-0401 · NSC-639966 · Perifosina

Small molecule targets AKT1 via inhibition

Developed for
plasma cell myeloma · kidney cancer · neoplasm · anaplastic astrocytoma · anaplastic oligodendroglioma · brain cancer · breast cancer · cancer
+48 more · cancer of unknown primary site · colon carcinoma · gastrointestinal stromal tumor · leukemia · lymphoma · malignant pancreatic neoplasm · myelodysplastic syndrome · myelodysplastic/myeloproliferative disease · sarcoma · Waldenstrom macroglobulinemia · acute erythroid leukemia · acute megakaryoblastic leukemia in adult · acute myeloblastic leukemia with maturation · acute myeloblastic leukemia without maturation · acute myeloid leukemia with 11q23 abnormalities · acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) · acute myeloid leukemia with minimal differentiation · acute myeloid leukemia with t(8;21)(q22;q22) translocation · acute myeloid leukemia, t(16;16)(p13.1;q22) · acute myelomonocytic leukemia M4 · acute promyelocytic leukemia · adult acute monocytic leukemia · adult glioblastoma · adult oligodendroglioma · alveolar soft part sarcoma · blast phase chronic myelogenous leukemia, BCR-ABL1 positive · childhood malignant neoplasm · chondrosarcoma · chronic lymphocytic leukemia/small lymphocytic lymphoma · cutaneous melanoma · diffuse astrocytoma · endometrial cancer · extraskeletal myxoid chondrosarcoma · giant cell glioblastoma · glioblastoma · gliosarcoma · head and neck cancer · leukemia, myeloid, accelerated-phase · malignant glioma · mixed glioma · non-small cell lung carcinoma · ovarian carcinoma · prostate cancer · renal cell carcinoma · soft tissue sarcoma · T-cell adult acute lymphocytic leukemia · colorectal cancer · prostate carcinoma
Investigated by
AEterna Zentaris · National Cancer Institute (NCI) · Dana-Farber Cancer Institute · University of Wisconsin, Madison · Keryx Biopharmaceuticals · Memorial Sloan Kettering Cancer Center
+14 more · Duke University · Keryx / AOI Pharmaceuticals, Inc. · M.D. Anderson Cancer Center · NCIC Clinical Trials Group · Pfizer · University Health Network, Toronto · Andrew B Lassman, MD · Columbia University · Daphne Friedman · Eastern Cooperative Oncology Group · NATL COMP CA NETWORK · Online Collaborative Oncology Group · SCRI Development Innovations, LLC · Sarcoma Alliance for Research through Collaboration

Trials 40 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 115 trials
Phase 1 NCT02238496 Dec 2014 → Oct 2017 anaplastic astrocytoma, anaplastic oligodendroglioma, brain cancer, glioblastoma +1 Andrew B Lassman, MD Completed No outcome recorded
Phase 1 NCT01224730 Jan 2012 → Nov 2013 cancer AEterna Zentaris Completed No outcome recorded
Phase 1 NCT01049841 Jan 2010 → Mar 2017 childhood malignant neoplasm Memorial Sloan Kettering Cancer Center Completed No outcome recorded
Phase 1 NCT01048580 Oct 2009 → May 2011 colon carcinoma AEterna Zentaris Completed No outcome recorded
Phase 1 NCT00776867 Oct 2008 → Jul 2017 cancer Memorial Sloan Kettering Cancer Center Completed No outcome recorded
Phase 1 NCT00431054 Feb 2007 → May 2012 ovarian carcinoma M.D. Anderson Cancer Center Completed No outcome recorded
Phase 1 NCT00415064 Dec 2006 → Jul 2012 plasma cell myeloma AEterna Zentaris Completed No outcome recorded
Phase 1 NCT00399152 Oct 2006 → Dec 2008 gastrointestinal stromal tumor, kidney cancer AEterna Zentaris Completed No outcome recorded
Phase 1 NCT00398814 Oct 2006 → Sep 2011 kidney cancer AEterna Zentaris Completed No outcome recorded
Phase 1 NCT00301938 Dec 2005 → May 2012 T-cell adult acute lymphocytic leukemia, acute erythroid leukemia, acute megakaryoblastic leukemia in adult, acute myeloblastic leukemia with maturation +13 National Cancer Institute (NCI) Completed No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT01051557 Jan 2010 → Nov 2018 adult glioblastoma, adult oligodendroglioma, anaplastic astrocytoma, anaplastic oligodendroglioma +3 National Cancer Institute (NCI) Completed No outcome recorded
Phase 1/2 NCT00401011 Aug 2006 → Dec 2010 plasma cell myeloma AEterna Zentaris Completed No outcome recorded
Phase 221 trials
Phase 2 NCT00873457 Aug 2009 → Oct 2011 chronic lymphocytic leukemia/small lymphocytic lymphoma Daphne Friedman Completed No outcome recorded
Phase 2 NCT00498966 Jul 2007 → Jul 2011 kidney cancer AEterna Zentaris Completed No outcome recorded
Phase 2 NCT00448721 Mar 2007 → Oct 2010 renal cell carcinoma AEterna Zentaris Completed No outcome recorded
Phase 2 NCT00401388 Nov 2006 → Jan 2011 alveolar soft part sarcoma, chondrosarcoma, extraskeletal myxoid chondrosarcoma AEterna Zentaris Completed No outcome recorded
Phase 2 NCT00391560 Oct 2006 → Oct 2010 leukemia AEterna Zentaris Completed No outcome recorded
Phase 2 NCT00398710 Oct 2006 → Aug 2011 Waldenstrom macroglobulinemia AEterna Zentaris Completed No outcome recorded
Phase 2 NCT00422656 Sep 2006 → Jun 2009 Waldenstrom macroglobulinemia Dana-Farber Cancer Institute Completed No outcome recorded
Phase 2 NCT00455559 Aug 2006 → Nov 2010 gastrointestinal stromal tumor AEterna Zentaris Completed No outcome recorded
Phase 2 NCT00590954 May 2006 → Nov 2019 brain cancer, malignant glioma Memorial Sloan Kettering Cancer Center Completed No outcome recorded
Phase 2 NCT00375791 Dec 2005 → Dec 2010 plasma cell myeloma AEterna Zentaris Completed No outcome recorded
Phase 31 trial
Phase 3 NCT01002248 Dec 2009 → Mar 2013 plasma cell myeloma AEterna Zentaris Terminated No outcome recorded
Phase not applicable1 trial
NCT00847366 May 2008 → Dec 2012 breast cancer, non-small cell lung carcinoma, sarcoma AEterna Zentaris Completed No outcome recorded
Also used as a comparator or background therapy in 2 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/21 trial
Phase 1/2 NCT00399789 Comparator Sep 2004 → Dec 2010 non-small cell lung carcinoma AEterna Zentaris Completed No outcome recorded
Phase 31 trial
Phase 3 NCT01097018 Comparator Apr 2010 → Apr 2012 colorectal cancer AEterna Zentaris Completed No outcome recorded

Evidence & citations 11 cited values

Every value below carries the sentence it was read from. 46 sources stand behind the page.

FieldValueCited text
Known as Perifosine ClinicalTrials.gov intervention name — accepted as the source's own label NCT00847366
41

NCT00398710

NCT00054145

NCT00060437

NCT00053924

NCT00398879

NCT00301938

NCT00053781

NCT00375791

NCT00019656

NCT00590954

NCT00398697

NCT00401388

NCT00498966

NCT00398814

NCT00058214

NCT00064324

NCT00399152

NCT00062387

NCT01048580

NCT00053794

NCT01224730

NCT00389077

NCT00399126

NCT00415064

NCT01002248

NCT00401011

NCT02238496

NCT00431054

NCT00873457

NCT00399087

NCT00776867

NCT01097018

NCT01051557

NCT00422656

NCT01049841

NCT00448721

NCT00059982

NCT00455559

NCT00005794

NCT00399789

NCT00391560

Known as AEZS-104 ChEMBL registry synonym — accepted as the source's own label CHEMBL372764
Known as D-21226 “A phase II study of perifosine (D-21226) in patients with previously untreated metastatic or locally advanced soft tissue sarcoma: A National Cancer Institute of Canada...” PMID 16528479 Sep 2006
Known as D-21266 “A Phase II Study Of Perifosine (D-21266) In Patients With Previously Untreated Metastatic Or Locally Advanced Soft Tissue Sarcoma” NCT00053794
Known as KRX-0401 ChEMBL registry synonym — accepted as the source's own label CHEMBL372764
Known as NSC-639966 ChEMBL registry synonym — accepted as the source's own label CHEMBL372764
Known as Perifosina ChEMBL registry synonym — accepted as the source's own label CHEMBL372764
Action Inhibit “believed to inhibit MAP kinase (MAP-K), protein kinase C (PKC), Akt and other regulatory proteins” PMID 16528479 Sep 2006
Modality Small molecule “Perifosine, an oral alkylphospholipid structurally related to miltefosine, has marked activity against breast cancer cell lines and xenograft models, with broad spectrum...” PMID 17458693 Apr 2007
Route Oral “loading dose of oral perifosine” NCT00005794
Target AKT1 “Perifosine targets the lipid-binding PH domain of Akt and inhibits the translocation of Akt to the cell membrane” PMID 22419878 Mar 2012