Drugs / Perifosine
Trials 40
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 115 trials | ||||||
| Phase 1 | NCT02238496 | Dec 2014 → Oct 2017 | anaplastic astrocytoma, anaplastic oligodendroglioma, brain cancer, glioblastoma +1 | Andrew B Lassman, MD | Completed | No outcome recorded |
| Phase 1 | NCT01224730 | Jan 2012 → Nov 2013 | cancer | AEterna Zentaris | Completed | No outcome recorded |
| Phase 1 | NCT01049841 | Jan 2010 → Mar 2017 | childhood malignant neoplasm | Memorial Sloan Kettering Cancer Center | Completed | No outcome recorded |
| Phase 1 | NCT01048580 | Oct 2009 → May 2011 | colon carcinoma | AEterna Zentaris | Completed | No outcome recorded |
| Phase 1 | NCT00776867 | Oct 2008 → Jul 2017 | cancer | Memorial Sloan Kettering Cancer Center | Completed | No outcome recorded |
| Phase 1 | NCT00431054 | Feb 2007 → May 2012 | ovarian carcinoma | M.D. Anderson Cancer Center | Completed | No outcome recorded |
| Phase 1 | NCT00415064 | Dec 2006 → Jul 2012 | plasma cell myeloma | AEterna Zentaris | Completed | No outcome recorded |
| Phase 1 | NCT00398814 | Oct 2006 → Sep 2011 | kidney cancer | AEterna Zentaris | Completed | No outcome recorded |
| Phase 1 | NCT00399152 | Oct 2006 → Dec 2008 | gastrointestinal stromal tumor, kidney cancer | AEterna Zentaris | Completed | No outcome recorded |
| Phase 1 | NCT00301938 | Dec 2005 → May 2012 | T-cell adult acute lymphocytic leukemia, acute erythroid leukemia, acute megakaryoblastic leukemia in adult, acute myeloblastic leukemia with maturation +13 | National Cancer Institute (NCI) | Completed | No outcome recorded |
| Phase 1 | NCT00399126 | Nov 2004 → Jan 2009 | neoplasm | AEterna Zentaris | Completed | No outcome recorded |
| Phase 1 | NCT00399087 | Nov 2004 → Jan 2010 | neoplasm | AEterna Zentaris | Completed | No outcome recorded |
| Phase 1 | NCT00398697 | Aug 2004 → Jan 2006 | neoplasm | AEterna Zentaris | Completed | No outcome recorded |
| Phase 1 | NCT00005794 | Feb 2000 → Jul 2003 | cancer of unknown primary site | University of Wisconsin, Madison | Completed | No outcome recorded |
| Phase 1 | NCT00019656 | Aug 1999 → ? | cancer of unknown primary site, leukemia, lymphoma, myelodysplastic syndrome +1 | National Cancer Institute (NCI) | Completed | No outcome recorded |
| Phase 1/22 trials | ||||||
| Phase 1/2 | NCT01051557 | Jan 2010 → Nov 2018 | adult glioblastoma, adult oligodendroglioma, anaplastic astrocytoma, anaplastic oligodendroglioma +3 | National Cancer Institute (NCI) | Completed | No outcome recorded |
| Phase 1/2 | NCT00401011 | Aug 2006 → Dec 2010 | plasma cell myeloma | AEterna Zentaris | Completed | No outcome recorded |
| Phase 221 trials · 1 met primary | ||||||
| Phase 2 | NCT00873457 | Aug 2009 → Oct 2011 | chronic lymphocytic leukemia/small lymphocytic lymphoma | Daphne Friedman | Completed | No outcome recorded |
| Phase 2 | NCT00498966 | Jul 2007 → Jul 2011 | kidney cancer | AEterna Zentaris | Completed | No outcome recorded |
| Phase 2 | NCT00448721 | Mar 2007 → Oct 2010 | renal cell carcinoma | AEterna Zentaris | Completed | No outcome recorded |
| Phase 2 | NCT00401388 | Nov 2006 → Jan 2011 | alveolar soft part sarcoma, chondrosarcoma, extraskeletal myxoid chondrosarcoma | AEterna Zentaris | Completed | No outcome recorded |
| Phase 2 | NCT00391560 | Oct 2006 → Oct 2010 | leukemia | AEterna Zentaris | Completed | No outcome recorded |
| Phase 2 | NCT00398710 | Oct 2006 → Aug 2011 | Waldenstrom macroglobulinemia | AEterna Zentaris | Completed | No outcome recorded |
| Phase 2 | NCT00422656 | Sep 2006 → Jun 2009 | Waldenstrom macroglobulinemia | Dana-Farber Cancer Institute | Completed | No outcome recorded |
| Phase 2 | NCT00455559 | Aug 2006 → Nov 2010 | gastrointestinal stromal tumor | AEterna Zentaris | Completed | No outcome recorded |
| Phase 2 | NCT00590954 | May 2006 → Nov 2019 | brain cancer, malignant glioma | Memorial Sloan Kettering Cancer Center | Completed | No outcome recorded |
| Phase 2 | NCT00375791 | Dec 2005 → Dec 2010 | plasma cell myeloma | AEterna Zentaris | Completed | No outcome recorded |
| Phase 2 | NCT00398879 | Aug 2005 → Dec 2010 | colon carcinoma | AEterna Zentaris | Completed | Met primary |
| Phase 2 | NCT00389077 | Jan 2005 → Jul 2011 | lymphoma | AEterna Zentaris | Completed | No outcome recorded |
| Phase 2 | NCT00060437 | Oct 2003 → Apr 2004 | prostate cancer | National Cancer Institute (NCI) | Completed | No outcome recorded |
| Phase 2 | NCT00059982 | Jul 2003 → Aug 2005 | malignant pancreatic neoplasm | Eastern Cooperative Oncology Group | Completed | No outcome recorded |
| Phase 2 | NCT00053781 | Jun 2003 → Sep 2004 | cutaneous melanoma | NCIC Clinical Trials Group | Completed | No outcome recorded |
| Phase 2 | NCT00053794 | Jun 2003 → Sep 2004 | endometrial cancer, sarcoma | NCIC Clinical Trials Group | Completed | No outcome recorded |
| Phase 2 | NCT00064324 | Jun 2003 → Nov 2005 | soft tissue sarcoma | National Cancer Institute (NCI) | Completed | No outcome recorded |
| Phase 2 | NCT00054145 | Jun 2003 → Apr 2007 | breast cancer | University Health Network, Toronto | Completed | No outcome recorded |
| Phase 2 | NCT00062387 | May 2003 → Jan 2007 | head and neck cancer | National Cancer Institute (NCI) | Terminated | No outcome recorded |
| Phase 2 | NCT00053924 | May 2003 → May 2006 | malignant pancreatic neoplasm | University Health Network, Toronto | Completed | No outcome recorded |
| Phase 2 | NCT00058214 | Mar 2003 → Jan 2009 | prostate adenocarcinoma | National Cancer Institute (NCI) | Terminated | No outcome recorded |
| Phase 31 trial | ||||||
| Phase 3 | NCT01002248 | Dec 2009 → Mar 2013 | plasma cell myeloma | AEterna Zentaris | Terminated | No outcome recorded |
| Phase not applicable1 trial | ||||||
| — | NCT00847366 | May 2008 → Dec 2012 | breast cancer, non-small cell lung carcinoma, sarcoma | AEterna Zentaris | Completed | No outcome recorded |
| Comparator or background therapy2 trials | ||||||
| Phase 1/2 | NCT00399789 Comparator | Sep 2004 → Dec 2010 | non-small cell lung carcinoma | AEterna Zentaris | Completed | No outcome recorded |
| Phase 3 | NCT01097018 Comparator | Apr 2010 → Apr 2012 | colorectal cancer | AEterna Zentaris | Completed | No outcome recorded |
Evidence & citations 11 cited values
Every value below carries the sentence it was read from. 46 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Perifosine | ClinicalTrials.gov intervention name — accepted as the source's own label NCT00398814 ↗ |
| Known as | AEZS-104 | ChEMBL registry synonym — accepted as the source's own label CHEMBL372764 ↗ |
| Known as | D-21226 | “A phase II study of perifosine (D-21226) in patients with previously untreated metastatic or locally advanced soft tissue sarcoma: A National Cancer Institute of Canada...” PMID 16528479 ↗ Sep 2006 |
| Known as | D-21266 | “A Phase II Study Of Perifosine (D-21266) In Patients With Previously Untreated Metastatic Or Locally Advanced Soft Tissue Sarcoma” NCT00053794 ↗ |
| Known as | KRX-0401 | ChEMBL registry synonym — accepted as the source's own label CHEMBL372764 ↗ |
| Known as | NSC-639966 | ChEMBL registry synonym — accepted as the source's own label CHEMBL372764 ↗ |
| Known as | Perifosina | ChEMBL registry synonym — accepted as the source's own label CHEMBL372764 ↗ |
| Action | Inhibit | “believed to inhibit MAP kinase (MAP-K), protein kinase C (PKC), Akt and other regulatory proteins” PMID 16528479 ↗ Sep 2006 |
| Modality | Small molecule | “Perifosine, an oral alkylphospholipid structurally related to miltefosine, has marked activity against breast cancer cell lines and xenograft models, with broad spectrum...” PMID 17458693 ↗ Apr 2007 |
| Route | Oral | “loading dose of oral perifosine” NCT00005794 ↗ |
| Target | AKT1 | “Perifosine targets the lipid-binding PH domain of Akt and inhibits the translocation of Akt to the cell membrane” PMID 22419878 ↗ Mar 2012 |