Drugs / Dendritic Cell Vaccine
last change Aug 2026 re-read 3 minutes ago

Dendritic Cell Vaccine

Vaccine

Developed for
glioblastoma · HIV infectious disease · malignant glioma · melanoma · acute lymphoblastic leukemia · acute myeloid leukemia · adult T-cell leukemia/lymphoma · anaplastic astrocytoma
+9 more · brain cancer · colorectal neoplasm · cutaneous melanoma · head and neck squamous cell carcinoma · HER2 positive breast carcinoma · neoplastic meningitis · prostate cancer · refractory malignant neoplasm · triple-negative breast carcinoma
Investigated by
Cedars-Sinai Medical Center · Conselho Nacional de Desenvolvimento Científico e Tecnológico · Federal University of São Paulo · Baylor Research Institute · Edward Ziga · French National Agency for Research on AIDS and Viral Hepatitis
+18 more · Fundacion Clinic per a la Recerca Biomédica · H. Lee Moffitt Cancer Center and Research Institute · Juan C. Ramos, MD · Karolinska University Hospital · Macarena De La Fuente, MD · Memorial Sloan Kettering Cancer Center · National Cancer Institute (NCI) · National Cheng-Kung University Hospital · National Health Research Institutes, Taiwan · National Institutes of Health (NIH) · Oslo University Hospital · Rockefeller University · São Paulo Research Foundation · United States Department of Defense · University Hospital Erlangen · University of Maryland, Baltimore · University of Sao Paulo General Hospital · ViiV Healthcare

Trials 18

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 112 trials
Phase 1 NCT05321940 Nov 2023 → Nov 2025 acute lymphoblastic leukemia, acute myeloid leukemia, adult T-cell leukemia/lymphoma Juan C. Ramos, MD Withdrawn No outcome recorded
Phase 1 NCT05809752 Aug 2023 → Aug 2026 overdue HER2 positive breast carcinoma, neoplastic meningitis, triple-negative breast carcinoma H. Lee Moffitt Cancer Center and Research Institute Active not recruiting No outcome recorded
Phase 1 NCT05767684 Jun 2023 → Mar 2025 refractory malignant neoplasm National Health Research Institutes, Taiwan Unknown No outcome recorded
Phase 1 NCT02010606 Jan 2014 → Jan 2019 astrocytoma (excluding glioblastoma), brain neoplasm, glioblastoma Cedars-Sinai Medical Center Completed No outcome recorded
Phase 1 NCT01946373 Oct 2013 → Dec 2025 melanoma Karolinska University Hospital Unknown No outcome recorded
Phase 1 NCT01902771 Sep 2013 → Oct 2016 brain cancer, glioblastoma Edward Ziga Terminated No outcome recorded Stop: Enrollment
Phase 1 NCT01808820 Aug 2013 → Nov 2018 anaplastic astrocytoma, glioblastoma Macarena De La Fuente, MD Completed No outcome recorded
Phase 1 NCT01792505 Oct 2009 → Nov 2014 malignant glioma Cedars-Sinai Medical Center Completed No outcome recorded
Phase 1 NCT00796770 Nov 2008 → Sep 2011 HIV infectious disease Baylor Research Institute Completed No outcome recorded
Phase 1 NCT00492947 Jun 2007 → Jun 2010 head and neck squamous cell carcinoma University of Maryland, Baltimore Withdrawn No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT01197625 Sep 2010 → Sep 2024 prostate cancer Oslo University Hospital Unknown No outcome recorded
Phase 1/2 NCT00056134 Oct 2002 → Oct 2011 cutaneous melanoma University Hospital Erlangen Completed No outcome recorded
Phase 22 trials
Phase 2 NCT06805656 Jul 2026 → Jan 2027 expected HIV infectious disease Federal University of São Paulo Not yet recruiting No outcome recorded
Phase 2 NCT01413295 Aug 2011 → Sep 2014 colorectal neoplasm Fundacion Clinic per a la Recerca Biomédica Completed No outcome recorded
Phase 31 trial
Phase 3 NCT06749925 Jan 2026 → Jan 2028 expected glioblastoma University of Sao Paulo General Hospital Not yet recruiting No outcome recorded
Phase not applicable1 trial
— NCT02961829 Jul 2015 → Mar 2019 HIV infectious disease Federal University of São Paulo Completed No outcome recorded
Comparator or background therapy1 trial
Phase 1/2 NCT00402142 Comparator Nov 2006 → Dec 2011 HIV infectious disease Hospital Clinic of Barcelona Completed No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 20 sources stand behind the page.

FieldValueCited text
Known as Dendritic Cell Vaccine “The purpose of this study is to test the safety and effects of a special type of a cancer vaccine called a 'dendritic cell vaccine' in patients with either newly diagnosed or...” NCT02010606 ↗
18

NCT06805656 ↗

NCT00700167 ↗

NCT05321940 ↗

NCT01792505 ↗

NCT02961829 ↗

NCT00056134 ↗

NCT01197625 ↗

NCT06749925 ↗

NCT00576446 ↗

NCT01902771 ↗

Show 8 more sources

Known as BIIR/ANRS-HIVax-001 “vaccination with ex vivo generated interferon-alpha dendritic cells loaded with HIV-1 lipopeptides and activated with lipopolysaccharide (BIIR/ANRS-HIVax-001, the DC vaccine product).” NCT00796770 ↗
Known as DCV “The purpose of this study is to learn about the effects of the study treatment, Dendritic Cell Vaccine (DCV), to find the highest dose of the study treatment that can be given...” NCT05809752 ↗
Known as MDDCT “We developed a personalized Monocyte-Derived Dendritic-cell Therapy (MDDCT) for HIV-infected individuals on suppressive antiretroviral treatment and evaluated HIV-specific...” PMID 35022035 ↗ Jan 2022
Known as Monocyte-Derived Dendritic-cell Therapy “We developed a personalized Monocyte-Derived Dendritic-cell Therapy (MDDCT) for HIV-infected individuals on suppressive antiretroviral treatment and evaluated HIV-specific...” PMID 35022035 ↗ Jan 2022
Action Activate “The goal of this dendritic cell vaccine is to activate a patient's own immune system against their tumor.” NCT02010606 ↗
Modality Vaccine “Dendritic cell vaccine plus denileukin difitox” NCT00056134 ↗
Route Subcutaneous “Patients receive 4 pulsed DC vaccinations subcutaneously (SC)” NCT00056134 ↗