drugset / Trial / NCT01946373
T Cell Transfer With or Without Dendritic Cell Vaccination in Patients With Melanoma
Non-randomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this study is to learn if dendritic cell vaccine will increase the effect of tumor infiltrating lymphocytes given with chemotherapy and interleukin-2 in patients with melanoma.
Timeline
- Start
- 2013-10
- Primary completion
- 2025-12
- Completion
- 2025-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | DC vaccine | Vaccine | 1.5e+07 cells | Intramuscular |
| Subject | T cells | Cell therapy | 5e+10 cells | Intravenous |
| Background | Cyclophosphamide | Other / unclassified | 60 mg/kg | Intravenous |
| Background | Fludarabine | Small molecule | 25 mg/m2 | Intravenous |
| Background | aldesleukin | Protein / enzyme biologic | 100000 iu/kg | Intravenous |