Novartis receives EU approval for Farydak®, the first in its class of anticancer agents approved for patients with multiple myeloma novartis.com ↗
2015-06-26
Novartis Pharmaceuticals
Novartis drug Farydak® recommended by CHMP for EU approval to treat multiple myeloma, providing patients a new mechanism of action novartis.com ↗
2015-06-12
Novartis Pharmaceuticals
Novartis data at EHA show increased PFS benefit of Farydak® in new subgroup of patients with previously treated multiple myeloma novartis.com ↗
2015-02-23
Novartis Pharmaceuticals
Novartis receives FDA approval of Farydak®, the first HDAC inhibitor for patients with multiple myeloma novartis.com ↗
Evidence & citations 13 cited values
Every value below carries the sentence it was read from.
153 sources stand behind the page.
Field
Value
Cited text
Known as
panobinostat
“In this randomized phase 2 study, we evaluated the response rate and toxicity of panobinostat, a pan-HDI administered 30 mg orally 3 times weekly, with or without rituximab, in...” PMID 27166360 ↗May 2016109
“The purpose of this Phase I study is to find the maximum tolerated dose of MTX110 (a water-soluble Panobinostat nanoparticle formulation) and Gadolinium that can be given...” NCT04264143 ↗
“Panobinostat is designed to cause chemical changes in different groups of proteins that are attached to DNA (the genetic material of cells), which may slow the growth of cancer...” NCT01440582 ↗
“This study comprises of a dose-escalation and dose expansion phase and will determine the maximum tolerated dose of oral Panobinostat on a continuous schedule in adult in...” NCT00532389 ↗
“A phase II non-randomized single arm trial of oral panobinostat (LBH589) was conducted in patients with low or intermediate-1 risk myelodysplastic syndrome (MDS).” PMID 22072492 ↗Nov 2011
“Enrolled patients will receive 4 infusions per week of panobinostat (MTX110; 0.25 ml of 300 μM = 26.2 μg), per infusion into the ventricular access device” NCT04315064 ↗
“Panobinostat (LBH589) is a deacetylase inhibitor (DACi) which belongs to a structurally novel cinnamic hydroxamic acid class of compounds.” NCT01007968 ↗
“LBH589 (Panobinostat) is a new pill that works by blocking a special group of proteins called histone deacetylases (HDACs).” NCT01055795 ↗
“i.v. and Oral Panobinostat (LBH589) in Combination With i.v. Trastuzumab (Herceptin®) and i.v. Paclitaxel” NCT00788931 ↗
ClinicalTrials.gov intervention name — accepted as the source's own labelNCT01222936 ↗
Known as
LBH589
“An Expanded Treatment Protocol of Panobinostat (LBH589) in Combination With Bortezomib and Dexamethasone in Patients With Multiple Myeloma Who Have Had at Least One Prior Line...” NCT02204553 ↗60
“A Phase I Study of LBH589 (Panobinostat) in Combination With External Beam Radiotherapy for the Treatment of Prostate Cancer, Esophageal Cancer and Head and Neck Cancer” NCT00670553 ↗
“This summary will use Panobinostat (LBH589) in patients with neuroendocrine tumors to see how the patient's tumor responds to panobinostat.” NCT00985946 ↗
“Panobinostat (LBH589) is a deacetylase inhibitor (DACi) which belongs to a structurally novel cinnamic hydroxamic acid class of compounds.” NCT00997399 ↗
“Panobinostat (LBH589) is a deacetylase inhibitor (DACi) which belongs to a structurally novel cinnamic hydroxamic acid class of compounds.” NCT01007968 ↗
“Participants were administered LBH589 (panobinostat)in combination with bortezomib and dexamethasone 2 weeks on/1 week off.” NCT02290431 ↗
“i.v. and Oral Panobinostat (LBH589) in Combination With i.v. Trastuzumab (Herceptin®) and i.v. Paclitaxel” NCT00788931 ↗
“A Phase I Trial of Panobinostat (LBH589) and Epirubicin in Patients With Solid Tumor Malignancies” NCT00878904 ↗
“A Phase IB Study of the Histone Deacetylase Inhibitor Panobinostat (LBH589) Given Orally” NCT01159418 ↗
“Each patient will receive panobinostat (LBH589) and letrozole.” NCT01105312 ↗
“The purpose of this Phase I study is to find the maximum tolerated dose of MTX110 (a water-soluble Panobinostat nanoparticle formulation) and Gadolinium that can be given...” NCT04264143 ↗2
“Enrolled patients will receive 4 infusions per week of panobinostat (MTX110; 0.25 ml of 300 μM = 26.2 μg), per infusion into the ventricular access device” NCT04315064 ↗
“DESIGN: Here we evaluate the impact of in-vivo administration of vorinostat (VOR) and panobinostat (PNB) during clinical trials on natural killer (NK) cell function and phenotype.” PMID 30830886 ↗Mar 2019
Action
Inhibit
“Panobinostat is a potent, oral pan-deacetylase inhibitor (pan-DACi) that increases the acetylation of proteins involved in multiple oncogenic pathways.” PMID 22981498 ↗Sep 2012
Modality
Small molecule
“Panobinostat (LBH589) is a deacetylase inhibitor (DACi) which belongs to a structurally novel cinnamic hydroxamic acid class of compounds.” NCT00997399 ↗