Drugs / Mesenchymal stem cell
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Mesenchymal stem cell

Cell therapy

Developed for
type 1 diabetes mellitus · cirrhosis of liver · erectile dysfunction · liver failure · acute myocardial infarction · acute respiratory distress syndrome · amyotrophic lateral sclerosis · azoospermia
+63 more · chronic graft versus host disease · COVID-19 · hypoplastic left heart syndrome · lupus nephritis · osteoarthritis · osteoarthritis, knee · pneumonia · transplant rejection · acute graft versus host disease · adult acute respiratory distress syndrome · AIDS · alcoholic liver cirrhosis · Alzheimer disease · anal fistula · aplastic anemia · bronchopulmonary dysplasia · chronic apical periodontitis · chronic granulomatous disease · chronic pancreatitis · chronic transplant rejection · combined immunodeficiency due to partial RAG1 deficiency · common variable immunodeficiency · congenital heart disease · connective tissue disorder · dental pulp necrosis · DiGeorge syndrome · disease of bone structure · disease of the tendon · disease related to solid organ transplantation · GATA2 deficiency with susceptibility to MDS/AML · Huntington disease · immune dysregulation, autoimmunity, and autoinflammation · immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome · immunodeficiency 88 · immunodysregulation with variable immunodeficiency and autoimmunity · interstitial lung disease · intervertebral disk degenerative disorder · intracerebral hemorrhage · Klinefelter syndrome · metabolic disease · multiple sclerosis · Omenn syndrome · osteoarthritis, hip · osteogenesis imperfecta · osteonecrosis · osteoporosis · Parkinson disease · primary biliary cholangitis · radiation cystitis · radiation proctitis · recombinase activating gene 2 deficiency · renal fibrosis · rotator cuff syndrome · spinal cord injury · STAT3-related early-onset multisystem autoimmune disease · systemic lupus erythematosus · transplant-related bronchiolitis obliterans · tuberculosis, spinal · congestive heart failure · coronary artery disorder · ischemic stroke · myocardial ischemia · renal artery disease
Investigated by
Royan Institute · Longeveron Inc. · Pharmicell Co., Ltd. · Ahmad Jabir Rahyussalim · Guangzhou General Hospital of Guangzhou Military Command · Mayo Clinic
+72 more · Stem Cells Arabia · Azidus Brasil · Cellavita Pesquisa Científica Ltda · Fuzhou General Hospital · Nanjing Medical University · National Heart, Lung, and Blood Institute (NHLBI) · Ossium Health, Inc. · University of Sao Paulo · 307 Hospital of PLA · Alzahra Hospital, Iran · Ann & Robert H Lurie Children's Hospital of Chicago · Asan Medical Center · Assistance Publique - Hôpitaux de Paris · Beijing 302 Hospital · Beijing YouAn Hospital · Catherine Bollard · Cell Energy Life Sciences Group Co. LTD · Chaitanya Hospital, Pune · Chinese Academy of Medical Sciences · Chinese PLA General Hospital · Conselho Nacional de Desenvolvimento Científico e Tecnológico · Fifth Hospital of Shijiazhuang City · Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal · Fundación de Ayuda a la Investigación sobre la Hipertensión pulmonar · Guangdong Prevention and Treatment Center for Occupational Diseases · Guangdong Provincial People's Hospital · Guangzhou Municipal Twelfth People's Hospital · Hospital Vera Cruz · Indonesia University · Instituto de Salud Carlos III · Jianming Tan · King Saud University · M.D. Anderson Cancer Center · Man Clinic for Andrology, Male Infertility and Sexual Dysfunction · Massachusetts General Hospital · Medical Center Medi-Art · Medical University of South Carolina · Mesoblast, Ltd. · Michael A. Matthay · National Cancer Institute (NCI) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · National Scientific Medical Center, Kazakhstan · Organ Transplant Institute, China · Paul Szabolcs · Paulo Brofman · Peking Union Medical College · Peking Union Medical College Hospital · Qipeng Sun · Robert Chunhua Zhao, MD, PhD · SCARM Institute, Tabriz, Iran · Shenzhen Third People's Hospital · St. Jude Children's Research Hospital · Stanford University · Sun Yat-sen University · Tehran University of Medical Sciences · The Second Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine · The University of Texas Health Science Center, Houston · Third Affiliated Hospital, Sun Yat-Sen University · Tianjin Nankai Hospital · Tianjin Weikai Bioeng., Ltd. · Universidad Central de Venezuela · Universidad de los Andes, Chile · University of Health Sciences Gulhane Faculty of Medicine · University of Minnesota · University of Pittsburgh · University of Science Ho Chi Minh City · Van Hanh General Hospital · Venezuelan Institute for Scientific Research · Yamaguchi University Hospital · Yonsei University · Zhejiang University · Zhujiang Hospital

Trials 72 · started per year

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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT00813267 Dec 2009 → Aug 2011 osteonecrosis Jianming Tan Unknown No outcome recorded
Phase 120 trials
Phase 1 NCT05443464 Jun 2023 → Jun 2024 acute graft versus host disease Ossium Health, Inc. Withdrawn No outcome recorded
Phase 1 NCT05407766 Aug 2022 → Apr 2024 anal fistula Ossium Health, Inc. Withdrawn No outcome recorded
Phase 1 NCT05095532 Dec 2021 → Jun 2027 expected chronic pancreatitis Medical University of South Carolina Recruiting No outcome recorded
Phase 1 NCT04236479 Jul 2020 → Dec 2026 expected congenital heart disease Catherine Bollard Active not recruiting No outcome recorded
Phase 1 NCT03929120 Nov 2019 → Jul 2021 connective tissue disorder, interstitial lung disease Mayo Clinic Completed No outcome recorded
Phase 1 NCT02443961 Apr 2019 → Apr 2020 bronchopulmonary dysplasia Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal Completed No outcome recorded
Phase 1 NCT03371329 Dec 2017 → Oct 2020 intracerebral hemorrhage Mayo Clinic Completed No outcome recorded
Phase 1 NCT02600130 Oct 2016 → Sep 2020 Alzheimer disease Longeveron Inc. Completed No outcome recorded
Phase 1 NCT03069170 Jul 2016 → Sep 2020 multiple sclerosis Stem Cells Arabia Unknown No outcome recorded
Phase 1 NCT02490020 Jan → Dec 2016 disease related to solid organ transplantation, transplant rejection Qipeng Sun Unknown No outcome recorded
Phase 1/223 trials
Phase 1/2 NCT05939167 Dec 2023 → Jul 2027 expected AIDS Cell Energy Life Sciences Group Co. LTD Recruiting No outcome recorded
Phase 1/2 NCT05433298 May → Nov 2022 COVID-19, pneumonia Paulo Brofman Withdrawn No outcome recorded
Phase 1/2 NCT04565665 Jul 2020 → Oct 2026 expected COVID-19, acute respiratory distress syndrome, cancer, hematopoietic and lymphoid cell neoplasm M.D. Anderson Cancer Center Active not recruiting No outcome recorded
Phase 1/2 NCT03460795 Jun 2020 → Mar 2025 cirrhosis of liver Nanjing Medical University Unknown No outcome recorded
Phase 1/2 NCT03863002 Oct 2019 → Oct 2021 liver failure Tianjin Weikai Bioeng., Ltd. Unknown No outcome recorded
Phase 1/2 NCT03460223 Apr 2018 → Mar 2020 renal fibrosis Nanjing Medical University Unknown No outcome recorded
Phase 1/2 NCT03525418 Feb 2018 → Jun 2024 hypoplastic left heart syndrome Longeveron Inc. Unknown No outcome recorded
Phase 1/2 NCT03484741 Apr 2017 → Nov 2018 type 1 diabetes mellitus Van Hanh General Hospital Unknown No outcome recorded
Phase 1/2 NCT02982915 Nov 2016 → Sep 2021 Longeveron Inc. Completed No outcome recorded
Phase 1/2 NCT02116634 May 2015 → May 2017 amyotrophic lateral sclerosis Alzahra Hospital, Iran Withdrawn No outcome recorded
Phase 219 trials
Phase 2 NCT07284641 May 2026 → May 2030 expected DiGeorge syndrome, GATA2 deficiency with susceptibility to MDS/AML, Omenn syndrome, STAT3-related early-onset multisystem autoimmune disease +8 Paul Szabolcs Recruiting No outcome recorded
Phase 2 NCT07544537 Sep 2024 → Jan 2026 overdue erectile dysfunction National Scientific Medical Center, Kazakhstan Active not recruiting No outcome recorded
Phase 2 NCT02587572 Dec 2023 metabolic disease Longeveron Inc. Withdrawn No outcome recorded
Phase 2 NCT04925024 Jun 2021 → Jun 2026 overdue hypoplastic left heart syndrome Longeveron Inc. Active not recruiting No outcome recorded
Phase 2 NCT02814864 Apr 2021 → Apr 2022 radiation cystitis, radiation proctitis Assistance Publique - Hôpitaux de Paris Unknown No outcome recorded
Phase 2 NCT03362424 Nov 2020 → Dec 2023 disease of the tendon, rotator cuff syndrome University of Sao Paulo Suspended No outcome recorded
Phase 2 NCT04594850 Oct 2020 → Jan 2026 erectile dysfunction Pharmicell Co., Ltd. Completed No outcome recorded
Phase 2 NCT04501354 Aug → Dec 2020 osteoporosis Ahmad Jabir Rahyussalim Unknown No outcome recorded
Phase 2 NCT04315987 Jun 2020 → Feb 2021 pneumonia Azidus Brasil Completed No outcome recorded
Phase 2 NCT03164083 Nov 2019 → Aug 2020 osteoarthritis SCARM Institute, Tabriz, Iran Withdrawn No outcome recorded
Phase 2/33 trials
Phase 2/3 NCT04545307 Nov → Dec 2019 chronic apical periodontitis, dental pulp necrosis Universidad Central de Venezuela Completed No outcome recorded
Phase 2/3 NCT02448849 Jun 2015 → Apr 2017 disease of bone structure Royan Institute Unknown No outcome recorded
Phase 2/3 NCT01526850 Feb 2012 → Dec 2013 chronic graft versus host disease Chinese Academy of Medical Sciences Unknown No outcome recorded
Phase 32 trials
Phase 3 NCT06097780 Jun 2024 → Sep 2025 Huntington disease Azidus Brasil Unknown No outcome recorded
Phase 3 NCT01652209 Sep 2013 → Aug 2024 acute myocardial infarction Pharmicell Co., Ltd. Completed No outcome recorded
Phase not applicable4 trials
NCT07400458 Mar 2022 → Oct 2028 expected acute myocardial infarction Pharmicell Co., Ltd. Recruiting No outcome recorded
NCT02414295 Aug 2013 → Aug 2014 Klinefelter syndrome, azoospermia Man Clinic for Andrology, Male Infertility and Sexual Dysfunction Completed No outcome recorded
NCT01499459 Jun 2008 → Jul 2012 cirrhosis of liver University of Health Sciences Gulhane Faculty of Medicine Unknown No outcome recorded
NCT00187018 Mar 2004 → Aug 2007 osteogenesis imperfecta St. Jude Children's Research Hospital Completed No outcome recorded
Also used as a comparator or background therapy in 9 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT04629105 Comparator Jul 2020 → Jun 2024 COVID-19, acute respiratory distress syndrome Longeveron Inc. Unknown No outcome recorded
Phase 1 NCT02266394 Comparator Oct 2014 → Sep 2020 chronic kidney disease, ischemic disease, renal artery disease Mayo Clinic Completed No outcome recorded
Phase 1 NCT00955669 Comparator Aug 2009 → Aug 2010 Third Military Medical University Completed No outcome recorded
Phase 1/23 trials
Phase 1/2 NCT01849887 Comparator Jan 2016 ischemic stroke University of California, Irvine Withdrawn No outcome recorded
Phase 1/2 NCT00644410 Comparator Sep 2008 → Mar 2015 congestive heart failure Rigshospitalet, Denmark Completed No outcome recorded
Phase 1/2 NCT00260338 Comparator Dec 2005 → Jul 2009 coronary artery disorder, myocardial ischemia Rigshospitalet, Denmark Completed No outcome recorded
Phase 22 trials
Phase 2 NCT04520945 Comparator Oct 2020 → Sep 2021 osteoarthritis, knee Meluha Life Sciences SDN BHD Unknown No outcome recorded
Phase 2 NCT02513238 Comparator Aug 2015 → Apr 2017 Rigshospitalet, Denmark Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT01392105 Comparator Mar 2007 → May 2010 acute myocardial infarction Yonsei University Completed No outcome recorded

Press releases naming this drug 2 releases

DateIssuerRelease
2022-12-19 Takeda Takeda’s Phase 3 AURORA Study Provides Evidence of Maribavir’s Clinically Meaningful and Durable Effect in Cytomegalovirus (CMV) Infection in Hematopoietic Stem Cell Transplant Patients, Despite Missing Primary Endpoint takeda.com
2016-12-06 AbbVie Late-Breaking Ibrutinib (IMBRUVICA®) Data Show Complete or Partial Response in Two-Thirds of Patients with Chronic Graft-Versus-Host-Disease, a Frequent and Potentially Life-Threatening Complication of Stem Cell Transplant abbvie.com

Evidence & citations 36 cited values

Every value below carries the sentence it was read from. 91 sources stand behind the page.

FieldValueCited text
Known as mesenchymal stem cell “In particular, mesenchymal stem cell (MSC) transplantation has been applicated in the clinic for treat several human diseases such as liver injury and liver fibrosis displayed...” NCT03460795
37

mesenchymal stem cell (MSC) transplantation has been applicated in the clinic for treat several human diseases” NCT03460223

“intraventricular injection of mesenchymal stem cell by stereotaxis” NCT01759784

“bone marrow derived cultured MSC (mesenchymal stem cell)” NCT03371329

“intra articular inection of mesenchymal stem cellNCT01499056

NCT01526850

NCT02181712

NCT05433298

NCT01725698

NCT02513238

NCT04493918

NCT04499105

NCT03362424

NCT01440309

NCT02266394

NCT01436058

NCT00659217

NCT02140528

NCT03863002

NCT02443961

NCT04565665

NCT00972660

NCT01504464

NCT02112500

NCT02414295

NCT00646724

NCT05939167

NCT01392105

NCT02490020

NCT01322789

NCT00813267

NCT01499459

NCT03164083

NCT01877759

NCT02116634

NCT04501354

NCT00659620

NCT01741090

Known as Allogeneic Bone Marrow-Derived Human Mesenchymal Stem Cells ClinicalTrials.gov intervention name — accepted as the source's own label NCT01775774
Known as BM-MSC “We first compared long-term clinical outcomes in treating critical limb ischemia (CLI) and foot ulcer in patients with diabetes between autologous bone marrow mesenchymal stem...” PMID 30917698 Mar 2019
5

“The investigators will evaluate safety and efficacy of percutaneous implantation of autologous BM-MSC (bone marrow -derived mesenchymal stromal cell) in combination with PL...” NCT02448849

“autologous bone marrow-derived mesenchymal stem cells (BM-MSC)” NCT03484741

NCT04545307

NCT04236479

NCT01844063

Known as BMD-MSCs “Allogeneic (coming from a healthy donor) Bone Marrow Derived Mesenchymal Stem Cells (BMD-MSCs)” NCT03929120
Known as BMMSCs “combination of bone marrow-derived mesenchymal stem cells (BM-MSCs), hydroxyapatite (HA) granules, bone morphogenetic protein-2 (BMP-2), and internal fixation for treating CSDs.” PMID 30747273 Feb 2019
2

“cultured autologous bone marrow derived mesenchymal stem cells (BM-MSCs)” NCT01436058

“autologous bone-marrow derived mesenchymal stromal cells (BMMSCs)” PMID 24211066 Oct 2013

Known as BMSC “Autologous Bone marrow-derived Mesenchymal Stem Cells (BMSC)” NCT07544537
Known as bone marrow -derived mesenchymal stromal cell “The investigators will evaluate safety and efficacy of percutaneous implantation of autologous BM-MSC (bone marrow -derived mesenchymal stromal cell) in combination with PL...” NCT02448849
Known as bone marrow derived mesenchymal stem cells “The patients with nonunion fracture who underwent percutaneous implantation of bone marrow derived mesenchymal stem cells in combination with platelet lysate product.” NCT02448849
9

NCT01305694

NCT01849887

NCT02327832

NCT07544537

NCT05095532

NCT01446640

NCT03929120

NCT00850187

NCT01446614

Known as bone marrow derived mesenchymal stromal/stem cell “Percutaneous implantation of autologous bone marrow derived mesenchymal stromal/stem cell in combination with PL will be done in 30 patients with tibia nonunion.” NCT02448849
Known as Bone Marrow Mesenchymal stem cells “autologous transplantation of Bone Marrow Mesenchymal stem cells (MSCs) mixed with collagen I scaffold” NCT00850187
Known as Bone marrow transplant ClinicalTrials.gov intervention name — accepted as the source's own label NCT00187018
Known as Cellgram-ED Cellgram-ED is autologous bone marrow-derived mesenchymal stem cells ex vivo expanded for approximately 30 days.” NCT02344849
1

NCT04594850

Known as Chondrogen ClinicalTrials.gov intervention name — accepted as the source's own label NCT04520945
1

NCT00702741

Known as Hearticellgram-AMI ClinicalTrials.gov intervention name — accepted as the source's own label NCT01652209
1

NCT07400458

Known as Hematopoietic stem cell transplant ClinicalTrials.gov intervention name — accepted as the source's own label NCT07284641
Known as hMSCs “Human bone marrow-derived mesenchymal stem (stromal) cells (hMSCs) improve survival in mouse models of acute respiratory distress syndrome (ARDS)” PMID 24891325 Jun 2014
Known as human MSCs “a phase 1/2 trial of bone marrow-derived human MSCs for moderate-severe ARDS.” PMID 25593740 Jul 2014
Known as laromestrocel “We conducted a randomized, dose-finding clinical trial to test whether human bone marrow-derived allogeneic mesenchymal stem cells (MSCs; laromestrocel) improve physical...” PMID 41747733 Feb 2026
Known as LMSCs “This is a Phase I, prospective, randomized, placebo-controlled, double-blinded study designed to test the safety and efficacy of LMSCs (Longeveron Mesenchymal Stem Cells) for...” NCT02600130
2

“evaluate the safety and efficacy of Longeveron Mesenchymal Stem Cells (LMSCs) in subjects with metabolic syndrome” NCT02587572

“Single peripheral IV infusion of 25 million Longeveron Mesenchymal Stem Cells (LMSCs)” NCT03169231

Known as Lomecel-B “This study is designed to assess the safety, tolerability, and efficacy of Lomecel-B (formerly LMSCs) as an adjunct therapy to the standard stage II (BDCPA) surgical...” NCT03525418
2

“Each subject will be intravenously infused with 100 million Lomecel-B (formerly LMSCs) or placebo on Day 0.” NCT04629105

NCT04925024

Known as Longeveron Mesenchymal Stem Cells “evaluate the safety and efficacy of Longeveron Mesenchymal Stem Cells (LMSCs) in subjects with metabolic syndrome” NCT02587572
2

NCT02600130

NCT03169231

Known as Longeveron Mesenchymal Stem Cells (LMSCs) ClinicalTrials.gov intervention name — accepted as the source's own label NCT02982915
Known as mesenchymal stem (stromal) cells “Human bone marrow-derived mesenchymal stem (stromal) cells (hMSCs) improve survival in mouse models of acute respiratory distress syndrome (ARDS)” PMID 24891325 Jun 2014
1

“human allogeneic bone marrow-derived mesenchymal stem/stromal cells” PMID 38114796 Dec 2023

Known as mesenchymal stem cells mesenchymal stem cells (MSCs) are collected from autologous bone marrow mononuclear cells” NCT03484741
1

“allogeneic, bone marrow (BM) derived mesenchymal stem cells (MSC)” NCT03371329

Known as Mesenchymal Stromal Cell “autologous bone-marrow derived mesenchymal stromal cells (BMMSCs)” PMID 24211066 Oct 2013
3

“Umbilical cord-derived Mesenchymal Stromal CellNCT03917797

NCT00644410

NCT02814864