Drugs / Golidocitinib
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Golidocitinib

Small molecule targets JAK1, STAT3 via inhibition

Developed for
peripheral T-cell lymphoma, not otherwise specified · mature T-cell and NK-cell non-Hodgkin lymphoma · non-small cell lung carcinoma · extranodal nasal NK/T cell lymphoma · aplastic anemia · autoimmune thrombocytopenia · enteropathy-associated T-cell lymphoma · Epstein-Barr virus infection
+9 more · hematologic disorder · hemophagocytic syndrome · mycosis fungoides and variants · refractory malignant neoplasm · secondary hemophagocytic lymphohistiocytosis · small cell lung carcinoma · T-cell and NK-cell neoplasm · T-cell large granular lymphocyte leukemia · T-cell non-Hodgkin lymphoma
Investigated by
Dizal Pharmaceuticals · Ruijin Hospital · Sun Yat-sen University · Beijing Friendship Hospital · Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Fudan University
+18 more · Peking University Cancer Hospital & Institute · Beijing Tongren Hospital · Dizal Pharmaceuticals · Henan Cancer Hospital · Institute of Hematology & Blood Diseases Hospital, China · LIANG WANG · M.D. Anderson Cancer Center · Peking Union Medical College Hospital · Peking University People's Hospital · Shanghai Cancer Hospital, China · Shanghai Chest Hospital · Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine · Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University · Tarapeutics Science Inc. · The First Affiliated Hospital of Guangzhou Medical University · Washington University School of Medicine · Wei Xu · Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

Trials 44 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT06969612 May 2025 → May 2027 expected non-small cell lung carcinoma Peking University Cancer Hospital & Institute Recruiting No outcome recorded
Phase 1 NCT05486949 Jul → Oct 2022 Dizal Pharmaceuticals Completed No outcome recorded
Phase 1 NCT04225208 Jan → Mar 2020 Dizal Pharmaceuticals Completed No outcome recorded
Phase 1 NCT03728023 Nov 2018 → Aug 2019 Dizal Pharmaceuticals Completed No outcome recorded
Phase 1/216 trials
Phase 1/2 NCT07706959 Jul 2026 → Jan 2028 expected peripheral T-cell lymphoma, not otherwise specified Ruijin Hospital Not yet recruiting No outcome recorded
Phase 1/2 NCT07496229 Apr 2026 → Sep 2029 expected T-cell non-Hodgkin lymphoma Dizal Pharmaceuticals Recruiting No outcome recorded
Phase 1/2 NCT07525466 Apr 2026 → Mar 2028 expected extranodal nasal NK/T cell lymphoma, secondary hemophagocytic lymphohistiocytosis Beijing Tongren Hospital Recruiting No outcome recorded
Phase 1/2 NCT07493330 Mar 2026 → Dec 2029 expected refractory malignant neoplasm Ruijin Hospital Not yet recruiting No outcome recorded
Phase 1/2 NCT07339527 Jan 2026 → Jan 2028 expected mature T-cell and NK-cell non-Hodgkin lymphoma Sun Yat-sen University Not yet recruiting No outcome recorded
Phase 1/2 NCT07297550 Dec 2025 → Dec 2026 expected aplastic anemia Institute of Hematology & Blood Diseases Hospital, China Not yet recruiting No outcome recorded
Phase 1/2 NCT07196163 Oct 2025 → Oct 2028 expected autoimmune thrombocytopenia Peking University People's Hospital Not yet recruiting No outcome recorded
Phase 1/2 NCT07209163 Oct 2025 → Mar 2026 overdue peripheral T-cell lymphoma, not otherwise specified Ruijin Hospital Not yet recruiting No outcome recorded
Phase 1/2 NCT07093710 Aug 2025 → Aug 2027 expected peripheral T-cell lymphoma, not otherwise specified Sun Yat-sen University Recruiting No outcome recorded
Phase 1/2 NCT06966154 May 2025 → May 2027 expected T-cell and NK-cell neoplasm, extranodal nasal NK/T cell lymphoma Fudan University Recruiting No outcome recorded
Phase 218 trials
Phase 2 NCT07682792 Sep 2026 → Jan 2030 expected T-cell large granular lymphocyte leukemia, mycosis fungoides and variants Washington University School of Medicine Not yet recruiting No outcome recorded
Phase 2 NCT07380984 Mar 2026 → Feb 2029 expected mature T-cell and NK-cell non-Hodgkin lymphoma Ruijin Hospital Recruiting No outcome recorded
Phase 2 NCT07457177 Feb 2026 → Jan 2028 expected extranodal nasal NK/T cell lymphoma LIANG WANG Not yet recruiting No outcome recorded
Phase 2 NCT07303881 Feb 2026 → Jun 2027 expected hematologic disorder, lung cancer The First Affiliated Hospital of Guangzhou Medical University Not yet recruiting No outcome recorded
Phase 2 NCT07385989 Jan 2026 → Dec 2028 expected mature T-cell and NK-cell non-Hodgkin lymphoma Wei Xu Not yet recruiting No outcome recorded
Phase 2 NCT07279584 Dec 2025 → Dec 2026 expected peripheral T-cell lymphoma, not otherwise specified Ruijin Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07110103 Oct 2025 → Mar 2027 expected small cell lung carcinoma Cancer Institute and Hospital, Chinese Academy of Medical Sciences Recruiting No outcome recorded
Phase 2 NCT07081607 Jul 2025 → Jul 2026 overdue peripheral T-cell lymphoma, not otherwise specified Ruijin Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07032532 Jul 2025 → Dec 2028 expected peripheral T-cell lymphoma, not otherwise specified Sun Yat-sen University Not yet recruiting No outcome recorded
Phase 2 NCT06630091 Feb 2025 → Jul 2027 expected peripheral T-cell lymphoma, not otherwise specified M.D. Anderson Cancer Center Recruiting No outcome recorded
Phase 2/32 trials
Phase 2/3 NCT07369739 Jan 2026 → Jan 2027 expected Epstein-Barr virus infection, histiocytosis Beijing Friendship Hospital Recruiting No outcome recorded
Phase 2/3 NCT07339345 Jun 2025 → Jun 2026 overdue hemophagocytic syndrome Beijing Friendship Hospital Recruiting No outcome recorded
Phase 34 trials
Phase 3 NCT07639879 Jul 2026 → Jul 2029 expected mature T-cell and NK-cell non-Hodgkin lymphoma Tarapeutics Science Inc. Not yet recruiting No outcome recorded
Phase 3 NCT07300514 Mar 2026 → Dec 2028 expected Fudan University Recruiting No outcome recorded
Phase 3 NCT07414758 Feb 2026 → Sep 2028 expected peripheral T-cell lymphoma, not otherwise specified Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Recruiting No outcome recorded
Phase 3 NCT07234162 May 2024 → Nov 2027 expected peripheral T-cell lymphoma, not otherwise specified Dizal Pharmaceuticals Recruiting No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 46 sources stand behind the page.

FieldValueCited text
Known as golidocitinib “Investigator's choice treatment with chidamide, golidocitinib, mitoxantrone hydrochloride liposome, or gemcitabine hydrochloride administered according to the respective...” NCT07639879
36

Golidocitinib combined with Pomalidomide” NCT06855823

NCT07525466

NCT07297550

NCT06690671

NCT07682792

NCT06573138

NCT07300514

NCT06966154

NCT07493330

NCT07385989

NCT07303881

NCT07339345

NCT07081607

NCT07457177

NCT06739265

NCT07209163

NCT07706959

NCT07196163

NCT07093710

NCT07380984

NCT07279584

NCT06969612

NCT06701344

NCT04105010

NCT07234162

NCT06733051

NCT05963347

NCT06757387

NCT06630091

NCT07110103

NCT07369739

NCT06198907

NCT07496229

NCT07414758

NCT07339527

NCT07032532

Known as AZD4205 ClinicalTrials.gov intervention name — accepted as the source's own label NCT04225208
6

NCT03728023

NCT05486949

NCT06295432

NCT03450330

NCT06511895

NCT06511869

Known as AZD4205 free base ChEMBL registry synonym — accepted as the source's own label CHEMBL4577523
Known as 戈利昔替尼 “Golidocitinib (Chinese name: 戈利昔替尼) is an oral, potent, and highly selective JAK1 inhibitor” NCT07300514
Action Inhibit “Oral Janus Kinase Inhibitor, AZD4205” NCT03450330
Modality Small molecule CHEMBL4577523
Route Oral “Assessing an Oral Janus Kinase Inhibitor, AZD4205” NCT03450330
Target JAK1 “a highly selective JAK1 inhibitor” PMID 37077916 Apr 2023