Drugs / Levamisole
last change Feb 2026 re-read 2 minutes ago

Levamisole

Small molecule

Developed for
colorectal cancer · aplastic anemia · hepatocellular carcinoma · loiasis · paroxysmal nocturnal hemoglobinuria · acne · autoimmune hemolytic anemia · COVID-19
+7 more · idiopathic steroid-sensitive nephrotic syndrome · malignant colon neoplasm · neoplasm · ascariasis · nephrotic syndrome · respiratory tract infectious disorder · trichuriasis
Investigated by
Institute of Hematology & Blood Diseases Hospital, China · The First Affiliated Hospital of Zhengzhou University · Anyang Tumor Hospital · Luoyang Central Hospital · Nanyang Central Hospital · National Cancer Institute (NCI)
+24 more · Programme National de Lutte contre l'Onchocercose, Republic of the Congo · Sanmenxia Central Hospital · Third People's Hospital of Jiaozuo · Ahvaz Jundishapur University of Medical Sciences · Assistance Publique - Hôpitaux de Paris · Austrian Breast & Colorectal Cancer Study Group · Cancer and Leukemia Group B · Dr. Frank Arguello Cancer Clinic · Eastern Cooperative Oncology Group · European Institute of Oncology · Fasa University of Medical Sciences · First Affiliated Hospital of Xinjiang Medical University · Instituto de Ciencia y Medicina Genomica, Torreon, Coah. Mexico www.institutodeciencia.com · NCIC Clinical Trials Group · NSABP Foundation Inc · North Central Cancer Treatment Group · Northern California Cancer Center · Pingdingshan Coal Medical Group General Hospital · Radiation Therapy Oncology Group · Research Institute for Development · SWOG Cancer Research Network · Shengyun Lin · Shiraz University of Medical Sciences · pinmei Group General Hospital

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) ERGAMISOL 1990-06-18 fda.gov

Trials 19 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 27 trials
Phase 2 NCT04049630 Jan → Apr 2021 loiasis, ocular onchocerciasis Programme National de Lutte contre l'Onchocercose, Republic of the Congo Completed No outcome recorded
Phase 2 NCT02203396 Aug 2014 → Sep 2016 aplastic anemia Institute of Hematology & Blood Diseases Hospital, China Completed No outcome recorded
Phase 2 NCT01760096 Jan 2013 → Jul 2016 bone marrow failure syndrome, paroxysmal nocturnal hemoglobinuria, thrombotic disease Institute of Hematology & Blood Diseases Hospital, China Unknown No outcome recorded
Phase 2 NCT01642979 Jul 2012 → Jul 2016 bone marrow failure syndrome, paroxysmal nocturnal hemoglobinuria, thrombotic disease Institute of Hematology & Blood Diseases Hospital, China Unknown No outcome recorded
Phase 2 NCT01579110 Apr 2012 → Apr 2015 autoimmune hemolytic anemia Institute of Hematology & Blood Diseases Hospital, China Unknown No outcome recorded
Phase 2 NCT02366884 Jul 2011 → Dec 2022 neoplasm Dr. Frank Arguello Cancer Clinic Unknown No outcome recorded
Phase 2 NCT00705692 Mar → Oct 2008 Shiraz University of Medical Sciences Completed No outcome recorded
Phase 2/33 trials
Phase 2/3 NCT06252961 Jun → Sep 2024 overdue loiasis Programme National de Lutte contre l'Onchocercose, Republic of the Congo Recruiting No outcome recorded
Phase 2/3 NCT04331470 Apr 2020 COVID-19 Fasa University of Medical Sciences Unknown No outcome recorded
Phase 2/3 NCT01348321 Nov 2008 → Oct 2009 acne Ahvaz Jundishapur University of Medical Sciences Completed No outcome recorded
Phase 38 trials
Phase 3 NCT04611373 May → Dec 2020 hepatocellular carcinoma The First Affiliated Hospital of Zhengzhou University Unknown No outcome recorded
Phase 3 NCT03950518 Apr 2019 → Apr 2023 hepatocellular carcinoma The First Affiliated Hospital of Zhengzhou University Unknown No outcome recorded
Phase 3 NCT03940378 Feb 2019 → Feb 2023 The First Affiliated Hospital of Zhengzhou University Unknown No outcome recorded
Phase 3 NCT02818738 Sep 2017 → Feb 2021 idiopathic steroid-sensitive nephrotic syndrome Assistance Publique - Hôpitaux de Paris Completed No outcome recorded
Phase 3 NCT00002551 Mar 1994 → Aug 2006 colorectal cancer SWOG Cancer Research Network Completed No outcome recorded
Phase 3 NCT00003063 Nov 1991 → ? colorectal cancer European Institute of Oncology Unknown No outcome recorded
Phase 3 NCT00309530 Oct 1990 → ? malignant colon neoplasm Austrian Breast & Colorectal Cancer Study Group Completed No outcome recorded
Phase 3 NCT00425152 Jul 1989 → Jun 1998 colorectal cancer NSABP Foundation Inc Completed No outcome recorded
Phase not applicable1 trial
NCT03218657 Jan 2018 → Jul 2019 aplastic anemia Shengyun Lin Unknown No outcome recorded
Also used as a comparator or background therapy in 5 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 33 trials
Phase 3 NCT04360122 Comparator May → Nov 2020 COVID-19 Ain Shams University Unknown No outcome recorded
Phase 3 NCT04383717 Comparator May → Aug 2020 respiratory tract infectious disorder Cairo University Unknown No outcome recorded
Phase 3 NCT00002593 Comparator Dec 1994 → Dec 1999 colorectal cancer SWOG Cancer Research Network Completed No outcome recorded
Phase 42 trials
Phase 4 NCT05772871 Comparator Apr 2023 → Sep 2025 nephrotic syndrome Jianhua Zhou Unknown No outcome recorded
Phase 4 NCT00659997 Comparator Jun → Sep 2006 ascariasis, trichuriasis Natural History Museum, United Kingdom Completed No outcome recorded

Evidence & citations 18 cited values

Every value below carries the sentence it was read from. 26 sources stand behind the page.

FieldValueCited text
Known as Levamisole “Nitazoxanide, Chloroquine, Albendazole, Ivermectin, Mebendazole, Metronidazole, Praziquantel, LevamisoleNCT02366884
19

“Clinical Trial Evaluating the Safety and Efficacy of Levamisole in Loa Loa Microfilaremic Patients” NCT04049630

NCT04383717

NCT02818738

NCT01760096

NCT01642979

NCT06252961

NCT00002593

NCT02203396

NCT00659997

NCT04360122

NCT00705692

NCT00425152

NCT04611373

NCT01579110

NCT05772871

NCT03950518

NCT04331470

NCT01348321

NCT00003063

Known as Ascaridil ChEMBL registry synonym — accepted as the source's own label CHEMBL1454
Known as Ergamisol ChEMBL registry synonym — accepted as the source's own label CHEMBL1454
Known as Ketrax ChEMBL registry synonym — accepted as the source's own label CHEMBL1454
Known as L-narpenol ChEMBL registry synonym — accepted as the source's own label CHEMBL1454
Known as LEV “A single dose of levamisole (LEV) induces a temporary, progressive MFD decrease.” PMID 40615414 Jul 2025
Known as levamisol ClinicalTrials.gov intervention name — accepted as the source's own label NCT00309530
Known as Levamisole hcl ChEMBL registry synonym — accepted as the source's own label CHEMBL1454
Known as levamisole hydrochloride levamisole hydrochlorideNCT00425152
3

NCT03218657

NCT03940378

NCT00002551

Known as Levamisoli hydrochloridum ChEMBL registry synonym — accepted as the source's own label CHEMBL1454
Known as NSC-177023 “Arm II: Single-agent Chemotherapy with Drug Modulation plus Biological Response Modifier Therapy. 5-FU; with CF; plus Levamisole, LEV, NSC-177023.” NCT00425152
Known as R 12,564 ChEMBL registry synonym — accepted as the source's own label CHEMBL1454
Known as R 12654 ChEMBL registry synonym — accepted as the source's own label CHEMBL1454
Known as Solaskil ChEMBL registry synonym — accepted as the source's own label CHEMBL1454
Known as Spartakon l ChEMBL registry synonym — accepted as the source's own label CHEMBL1454
Known as TCMDC-125847 ChEMBL registry synonym — accepted as the source's own label CHEMBL1454
Modality Small molecule “Levamisole 50 mg tablet” NCT04331470
Route Oral “Patients also receive oral levamisole twice daily on days 1-3, 15-17, 29-31, and 43-45.” NCT00002551