Drugs / PH-797804
last change Jun 2014 re-read 9 days ago

PH-797804

Small molecule targets MAPK14 via inhibition

Developed for
chronic obstructive pulmonary disease · rheumatoid arthritis · osteoarthritis · postherpetic neuralgia
Investigated by
Pfizer

Trials 16

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 19 trials
Phase 1 NCT01924650 Mar → Jun 2014 — Pfizer Withdrawn No outcome recorded
Phase 1 NCT01862887 Apr → Aug 2013 — Pfizer Completed No outcome recorded
Phase 1 NCT01589614 Jun → Aug 2012 — Pfizer Completed No outcome recorded
Phase 1 NCT01479647 Dec 2011 → Feb 2012 — Pfizer Completed No outcome recorded
Phase 1 NCT01314885 Jan → Dec 2011 chronic obstructive pulmonary disease Pfizer Completed No outcome recorded
Phase 1 NCT01226693 Nov 2010 → Mar 2011 — Pfizer Completed No outcome recorded
Phase 1 NCT01217918 Oct 2010 → Feb 2011 — Pfizer Completed No outcome recorded
Phase 1 NCT00827515 Feb → Apr 2009 — Pfizer Withdrawn No outcome recorded
Phase 1 NCT02084485 Sep 2006 → Mar 2008 — Pfizer Completed No outcome recorded
Phase 27 trials · 1 met primary · 1 missed
Phase 2 NCT01543919 Apr 2012 → Sep 2013 chronic obstructive pulmonary disease Pfizer Completed No outcome recorded
Phase 2 NCT01321463 May 2011 → Jun 2012 chronic obstructive pulmonary disease Pfizer Completed No outcome recorded
Phase 2 NCT01102660 May 2010 → Feb 2011 osteoarthritis Pfizer Completed No outcome recorded
Phase 2 NCT00614705 Apr → Nov 2008 postherpetic neuralgia Pfizer Completed No outcome recorded
Phase 2 NCT00620685 Mar → Oct 2008 rheumatoid arthritis Pfizer Completed No outcome recorded
Phase 2 NCT00559910 Feb 2008 → Dec 2009 chronic obstructive pulmonary disease Pfizer Completed Met primary
Phase 2 NCT00383188 Dec 2006 → Jul 2008 rheumatoid arthritis Pfizer Completed Missed primary

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 17 sources stand behind the page.

FieldValueCited text
Known as PH-797804 “Study A6631027 will evaluate the safety, tolerability and pharmacokinetics of PH-797804 when administered to healthy Japanese subjects once a day (QD) for 10 days.” NCT01217918 ↗
15

NCT00620685 ↗

NCT01102660 ↗

NCT01924650 ↗

NCT00827515 ↗

NCT00383188 ↗

NCT00614705 ↗

NCT01862887 ↗

NCT01543919 ↗

NCT01479647 ↗

NCT01226693 ↗

Show 5 more sources

Action Inhibit “MAP kinase p38 alpha inhibitor” CHEMBL1088751 ↗
1

“A p38 inhibitor” NCT00383188 ↗

Modality Small molecule — CHEMBL1088751 ↗
Route Oral “administered orally once daily” NCT00383188 ↗
Target MAPK14 “MAP kinase p38 alpha inhibitor” CHEMBL1088751 ↗