drugset / Trial / NCT01314885
Single Dose Lipopolysaccharide (LPS) Study In Healthy Volunteers
RandomizedCrossoverDouble-blind
Summary
A single dose study with the inhaled anti-inflammatory agent PF-03715455 to establish if it has anti-inflammatory activity following a challenge with LPS. Inhaled LPS invokes an acute inflammatory response in the lung which can be seen in induced sputum. PH-0797804 is an internal control for the study.
Timeline
- Start
- 2011-01
- Primary completion
- 2011-12
- Completion
- 2011-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | PF-03715455 | Small molecule | 20 mg | Inhaled |
| Subject | PH-797804 | Small molecule | 30 mg | Oral |