Sodium Hypochlorite
Trials 28
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 01 trial | ||||||
| Phase 0 | NCT02137967 | Aug 2011 → Sep 2014 | dental pulp disorder | National Taiwan University Hospital | Unknown | No outcome recorded |
| Phase 14 trials | ||||||
| Phase 1 | NCT07641933 | Jun 2026 → Jun 2027 expected | suppurative periapical periodontitis | Ain Shams University | Recruiting | No outcome recorded |
| Phase 1 | NCT05840679 | Apr → Oct 2023 | — | Armed Forces Institute of Dentistry, Pakistan | Unknown | No outcome recorded |
| Phase 1 | NCT04250519 | Feb 2020 → Feb 2021 | acute apical periodontitis | Tamil Nadu Dr.M.G.R.Medical University | Unknown | No outcome recorded |
| Phase 1 | NCT02241174 | Jul → Dec 2014 | atopic eczema | Makati Medical Center | Withdrawn | No outcome recorded Stop: Enrollment |
| Phase 24 trials | ||||||
| Phase 2 | NCT05306431 | Jun 2022 | pulpitis | Altamash Institute of Dental Medicine | Completed | No outcome recorded |
| Phase 2 | NCT06129643 | Jan → Oct 2022 | dental pulp necrosis, periapical periodontitis | Future University in Egypt | Completed | No outcome recorded |
| Phase 2 | NCT05964686 | Jan → Sep 2022 | dental pulp necrosis, periapical granuloma | Future University in Egypt | Completed | No outcome recorded |
| Phase 2 | NCT02203565 | Jul 2014 → Jul 2016 | breast cancer, radiodermatitis | Stanford University | Completed | No outcome recorded |
| Phase 32 trials · 1 missed | ||||||
| Phase 3 | NCT02369835 | May 2015 → Jul 2018 | head and neck carcinoma, radiodermatitis | Stanford University | Completed | Missed primary |
| Phase 3 | NCT01321125 | Apr → Dec 2011 | infectious disease | University of Guanajuato | Completed | No outcome recorded |
| Phase 42 trials | ||||||
| Phase 4 | NCT05424796 | Feb → Oct 2021 | pulpitis | Cumhuriyet University | Completed | No outcome recorded |
| Phase 4 | NCT04035070 | Jan → Jun 2021 | dental pulp necrosis | Cairo University | Unknown | No outcome recorded |
| Phase not applicable15 trials | ||||||
| — | NCT07653373 | Aug 2026 → Dec 2027 expected | — | Universidade Ceuma | Not yet recruiting | No outcome recorded |
| — | NCT07618182 | Jul → Dec 2026 expected | — | College of Physicians and Surgeons Pakistan | Not yet recruiting | No outcome recorded |
| — | NCT07453160 | Feb → Jun 2026 overdue | — | College of Physicians and Surgeons Pakistan | Not yet recruiting | No outcome recorded |
| — | NCT07637305 | Oct 2025 → Feb 2026 | acute apical periodontitis | Hasanuddin University | Completed | No outcome recorded |
| — | NCT07453576 | Oct 2025 → Dec 2026 expected | periapical periodontitis | KEZBAN MELTEM ÇOLAK | Recruiting | No outcome recorded |
| — | NCT06971055 | Jul → Sep 2025 overdue | dental caries, dental pulp necrosis, periapical periodontitis | Cairo University | Not yet recruiting | No outcome recorded |
| — | NCT07048028 | May → Nov 2025 overdue | acute apical periodontitis, dental pulp necrosis | ESRA DAĞCI | Recruiting | No outcome recorded |
| — | NCT07058727 | May → Nov 2025 overdue | — | Cukurova University | Recruiting | No outcome recorded |
| — | NCT07486245 | Mar → Nov 2025 | pulpitis | CMH Multan Institute of Medical Sciences | Completed | No outcome recorded |
| — | NCT06949176 | Dec 2023 → Dec 2024 overdue | periapical periodontitis | National and Kapodistrian University of Athens | Active not recruiting | No outcome recorded |
| — | NCT07120321 | Jan 2022 → Jan 2025 | dental caries, pulpitis | Sacide Duman | Completed | No outcome recorded |
| — | NCT05778227 | Nov 2021 → May 2023 | acute apical periodontitis, pulpitis, suppurative periapical periodontitis | Dow University of Health Sciences | Completed | No outcome recorded |
| — | NCT06597825 | Aug → Dec 2020 | — | Mustafa Kemal University | Completed | No outcome recorded |
| — | NCT04399187 | Apr 2018 → Sep 2019 | periodontal disorder | University of Messina | Completed | No outcome recorded |
| — | NCT01996150 | Jan 2014 → Jun 2017 | atopic eczema | University of Rochester | Completed | No outcome recorded |
| Comparator or background therapy19 trials | ||||||
| Phase 0 | NCT07823868 Comparator | Jan → Dec 2027 expected | acute apical periodontitis, dental pulp necrosis | Oman Dental College | Not yet recruiting | No outcome recorded |
| Phase 1 | NCT06811779 Comparator | Mar → Jun 2024 | acute apical periodontitis | Armed Forces Institute of Dentistry, Pakistan | Completed | No outcome recorded |
| Phase 2 | NCT03074136 Background | Feb → Dec 2017 | dental pulp disorder | Association of Paediatric and Preventive Dentists of Serbia | Completed | No outcome recorded |
| Phase 2/3 | NCT05348824 Comparator | Aug 2022 → Mar 2023 | dental pulp necrosis | Cairo University | Unknown | No outcome recorded |
| Phase 2/3 | NCT05146713 Comparator | Jan → Nov 2022 | dental pulp necrosis | Cairo University | Unknown | No outcome recorded |
| Phase 2/3 | NCT03719261 Comparator | Nov 2018 → Apr 2019 | — | Cairo University | Unknown | No outcome recorded |
| Phase 3 | NCT05974748 Comparator | Apr → Aug 2023 | pulpitis | Dow University of Health Sciences | Completed | No outcome recorded |
| Phase 4 | NCT07518901 Comparator | Aug 2026 → Jun 2028 expected | acute apical periodontitis, tooth disorder | University of Pennsylvania | Enrolling by invitation | No outcome recorded |
| Phase 4 | NCT04721457 Comparator | Jan → Mar 2021 | COVID-19 | King Abdulaziz University | Completed | No outcome recorded |
| Phase 4 | NCT04391660 Comparator | Jun 2020 → Jan 2021 | — | Poitiers University Hospital | Completed | No outcome recorded |
| Phase 4 | NCT00179959 Comparator | Sep 2005 → Mar 2011 | atopic eczema | Northwestern University | Completed | No outcome recorded |
| — | NCT07688005 Comparator | Sep → Nov 2026 expected | periapical periodontitis | Postgraduate Medical Institute, Lahore | Not yet recruiting | No outcome recorded |
| — | NCT07248189 Comparator | Oct → Dec 2025 | pulpitis | Cairo University | Completed | No outcome recorded |
| — | NCT06948526 Comparator | Jun 2025 → Jun 2026 overdue | — | Cairo University | Not yet recruiting | No outcome recorded |
| — | NCT05277246 Comparator | Mar → Jun 2022 | pulpitis | Yuzuncu Yil University | Unknown | No outcome recorded |
| — | NCT04035330 Background | Sep 2019 → Mar 2021 | dental pulp necrosis | Cairo University | Unknown | No outcome recorded |
| — | NCT03312153 Comparator | Aug 2019 → Feb 2020 | — | Cairo University | Unknown | No outcome recorded |
| — | NCT05445362 Comparator | Feb 2019 → Aug 2020 | — | Reham Hassan | Completed | No outcome recorded |
| — | NCT05291195 Background | Feb 2018 → Oct 2021 | chronic apical periodontitis, dental pulp necrosis | University of Belgrade | Completed | No outcome recorded |
Evidence & citations 8 cited values
Every value below carries the sentence it was read from. 49 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Sodium hypochlorite | “Three antiseptics will be tested: 2% chlorhexidine gluconate in 70% isopropyl alcohol, 10% sodium hypochlorite and 10% povidone-iodine, each one will be applied on the surface...” NCT01321125 ↗45“This study evaluated the postoperative pain intensity in permanent teeth with symptomatic irreversible pulpitis treated by pulpotomy using physiological saline, sodium...” PMID 37092958 ↗ Apr 2023 “Control arm: standard clinical irrigation with 3% sodium hypochlorite (NaOCl) using matched total volume and institutional activation method, with identical pre/post sampling...” NCT07518901 ↗ “Sodium hypochlorite (NaOCl), the most commonly used irrigation solution during chemomechanical preparation, plays a significant role in eliminating bacteria within root canals.” NCT06597825 ↗ “Sodium hypochlorite (NaOCl) solution is the standard irrigation agent for cleaning and disinfection of root canal.” NCT05277246 ↗ “Sodium hypochlorite (NaOCl) has been used in root canal irrigant for more than 80 years” NCT02137967 ↗ “conventional disinfection using 2.5% sodium hypochlorite and 17% EDTA” NCT05964686 ↗ “conventional disinfection using 2.5% sodium hypochlorite and 17% EDTA” NCT06129643 ↗ “20 ml of 1.5% (17) sodium hypochlorite (NaOCl) solution” NCT05445362 ↗ “3% and 6% sodium hypochlorite (NaOCl) as irrigant” NCT05840679 ↗ “Sodium hypochlorite” NCT01996150 ↗ |
| Known as | bleach | “sodium hypochlorite (NaOCl, also known as bleach)” NCT07453160 ↗ |
| Known as | Dakin | “The aim of this study is to estimate the colonization rate of peripheral venous catheters after skin disinfection with 0.5% sodium hypochlorite (Dakin®) alone or preceded by an...” NCT04391660 ↗ |
| Known as | Dakin's solution | ClinicalTrials.gov intervention name — accepted as the source's own label NCT02369835 ↗ |
| Known as | Except 10% | “The arm is composed of 30 human volunteers to test 2% chlorhexidine gluconate in 70% isopropyl alcohol (ChloraPrep ®, Enturia, Texas, USA ), hypochlorite 10% of electrochemical...” NCT01321125 ↗ |
| Known as | NaOCl | “This study evaluated the postoperative pain intensity in permanent teeth with symptomatic irreversible pulpitis treated by pulpotomy using physiological saline, sodium...” PMID 37092958 ↗ Apr 202314“A number of irrigant solution has thus been proposed to serve the purpose, the most popular being sodium hypochlorite (NaOCl) because of its excellent antimicrobial activity...” NCT05306431 ↗ “Sodium hypochlorite (NaOCL) is the most recommended irrigant due to its broad antibacterial effect, necrotic tissues and dentin collagen dissolving capability and inactivation...” NCT03719261 ↗ “Sodium hypochlorite (NaOCl): Strong antimicrobial properties, effective in dissolving pulp tissue, but can cause tissue irritation, swelling, and pain if extruded beyond the root apex.” NCT07486245 ↗ “Sodium hypochlorite (NaOCl), the most commonly used irrigation solution during chemomechanical preparation, plays a significant role in eliminating bacteria within root canals.” NCT06597825 ↗ “Vigorously rinse with 15 ml of the 80 ppm sodium hypochlorite (NaOCl) (Clinisept Dental Mouthwash; Clinical Health Technologies, Hinckley, Leicestershire, UK) for 30 s” NCT04721457 ↗ “This randomized clinical trial evaluates the efficacy of sodium hypochlorite (NaOCl), chlorhexidine (CHX), and cold saline as hemostatic agents in partial pulpotomy.” NCT07058727 ↗ “Sodium hypochlorite (NaOCl), the primary endodontic disinfectant, is available in both domestic-grade products and specialized medical-grade formulations.” PMID 41975390 ↗ Apr 2026 “Sodium hypochlorite (NaOCl) solution is the standard irrigation agent for cleaning and disinfection of root canal.” NCT05277246 ↗ “After each instrumentation, the root canals were irrigated with 1.5 % sodium hypochlorite (NaOCl).” NCT05291195 ↗ “Sodium hypochlorite (NaOCl) has been used in root canal irrigant for more than 80 years” NCT02137967 ↗ |
| Action | Inhibit | “suppression of S aureus growth with sodium hypochlorite (bleach) baths” PMID 19403473 ↗ May 2009 |
| Route | Other | “Sodium hypochlorite (bleach) baths twice weekly for 3 months” NCT00179959 ↗ |