Drugs / Cediranib
last change Jul 2026 re-read 2 minutes ago

Cediranib

Small molecule targets KIT

Developed for
colorectal cancer · non-small cell lung carcinoma · lung cancer · adult glioblastoma · gliosarcoma · ovarian cancer · ovarian endometrioid adenocarcinoma · primary peritoneal serous adenocarcinoma
+152 more · renal cell carcinoma · cancer · giant cell glioblastoma · neoplasm · alveolar soft part sarcoma · breast cancer · fallopian tube cancer · fallopian tube clear cell adenocarcinoma · fallopian tube endometrioid adenocarcinoma · fallopian tube serous adenocarcinoma · fallopian tube transitional cell carcinoma · glioblastoma · male breast carcinoma · ovarian clear cell adenocarcinoma · ovarian seromucinous carcinoma · ovarian serous adenocarcinoma · ovarian transitional cell carcinoma · primary peritoneal carcinoma · prostate adenocarcinoma · sarcomatoid mesothelioma · small cell lung carcinoma · undifferentiated ovarian carcinoma · adult hepatocellular carcinoma · cervical cancer · cutaneous melanoma · endometrial cancer · endometrial serous adenocarcinoma · fallopian tube carcinoma · malignant epithelial tumor of ovary · malignant epithelioid mesothelioma · metastatic malignant neoplasm · ovarian carcinoma · rectal carcinoma · refractory malignant neoplasm · triple-negative breast carcinoma · acral lentiginous melanoma · acute myeloid leukemia · acute myeloid leukemia with 11q23 abnormalities · acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) · acute myeloid leukemia with t(8;21)(q22;q22) translocation · adult anaplastic ependymoma · adult brainstem glioma · adult T-cell leukemia/lymphoma · anaplastic astrocytoma · anaplastic large cell lymphoma · anaplastic oligodendroglioma · angioimmunoblastic T-cell lymphoma · atypical teratoid rhabdoid tumor · B-cell chronic lymphocytic leukemia · biliary tract neoplasm · brain neoplasm · Burkitt lymphoma · carcinosarcoma · castration-resistant prostate carcinoma · cerebellar astrocytoma · childhood brain meningioma · childhood brain stem glioma · childhood central nervous system germ cell tumor · childhood central nervous system primitive neuroectodermal neoplasm · childhood cerebral astrocytoma · childhood malignant neoplasm · childhood medulloblastoma · childhood oligodendroglioma · childhood spinal cord tumor · cholangiocarcinoma · clear cell renal carcinoma · colon carcinoma · endometrial adenosquamous carcinoma · endometrial clear cell adenocarcinoma · endometrial endometrioid adenocarcinoma · endometrial mixed adenocarcinoma · endometrial undifferentiated carcinoma · exocrine pancreatic carcinoma · extranodal nasal NK/T cell lymphoma · fallopian tube mucinous adenocarcinoma · female breast carcinoma · gallbladder carcinoma · gastric cancer · gastrointestinal stromal tumor · grade II meningioma · grade III lymphomatoid granulomatosis · grade III meningioma · hairy cell leukemia · head and neck neoplasm · hepatosplenic T-cell lymphoma · high grade malignant neoplasm · Hodgkins lymphoma · hormone-resistant prostate carcinoma · hypopharynx squamous cell carcinoma · intestinal obstruction · intraocular lymphoma · iris melanoma · large-cell immunoblastic lymphoma · larynx verrucous carcinoma · leiomyosarcoma · lentigo maligna melanoma · major salivary gland carcinoma · malignant pleural mesothelioma · MALT lymphoma · mantle cell lymphoma · medium/large size posterior uveal melanoma · metastasis from malignant tumor of colon · metastatic malignant neoplasm in the brain · metastatic melanoma · metastatic prostate carcinoma · metastatic squamous cell carcinoma · mycosis fungoides and variants · myelodysplastic syndrome · myeloid leukemia · nasal cavity and paranasal sinus squamous cell carcinoma · nasopharyngeal squamous cell carcinoma · neurofibroma of spinal cord · neurofibromatosis type 1 · nodal marginal zone B-cell lymphoma · ocular melanoma with extraocular extension · optic pathway glioma · oropharynx squamous cell carcinoma · ovarian germ cell tumor · ovarian neoplasm · ovarian serous surface papillary adenocarcinoma · ovarian serous tumor · pancreatic adenocarcinoma · pancreatic ductal adenocarcinoma · pediatric infratentorial ependymoma · pediatric supratentorial ependymoma · periampullary adenocarcinoma · peripheral T-cell lymphoma, not otherwise specified · peritoneum cancer · pineoblastoma · plexiform neurofibroma · primary cutaneous B-cell lymphoma · prostate cancer · prostate neuroendocrine neoplasm · salivary gland squamous cell carcinoma · small intestine lymphoma · small size posterior uveal melanoma · soft tissue sarcoma · splenic marginal zone lymphoma · subependymal giant cell astrocytoma · superficial spreading melanoma · T-cell large granular lymphocyte leukemia · testicular lymphoma · thyroid gland papillary carcinoma · thyroid Hurthle cell carcinoma · tongue carcinoma · uterine adnexa cancer · uveal melanoma · verrucous carcinoma of oral cavity · Waldenstrom macroglobulinemia · breast carcinoma · peritoneal neoplasm · pleural neoplasm
Investigated by
National Cancer Institute (NCI) · AstraZeneca · NRG Oncology · NCIC Clinical Trials Group · University Health Network, Toronto · Alliance for Clinical Trials in Oncology
+30 more · Cancer Research UK · Cardiff University · Royal Marsden NHS Foundation Trust · University College, London · Beth Israel Deaconess Medical Center · CCTU- Cancer Theme · Canadian Cancer Trials Group · Institute of Cancer Research, United Kingdom · Korean Gynecologic Oncology Group · M.D. Anderson Cancer Center · MFAR · Mario Negri Institute for Pharmacological Research · Massachusetts General Hospital · Merck Sharp & Dohme LLC · Myriad Genetic Laboratories, Inc. · National Comprehensive Cancer Network · Prof Gordon Jayson · Radiation Therapy Oncology Group · Samsung Genomic Institute · Samsung Medical Center · Seoul National University Hospital · Spanish Melanoma Group · Susana M. Campos, MD · The Christie NHS Foundation Trust · University of Cambridge · University of Glasgow · University of Manchester · University of Oxford · Wyeth is now a wholly owned subsidiary of Pfizer · Yonsei University

Trials 99 · started per year

today
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2003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 129 trials
Phase 1 NCT01364051 May 2011 → Jun 2019 overdue cutaneous melanoma, metastatic melanoma, refractory malignant neoplasm National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 1 NCT01160926 Jul 2010 → Oct 2013 rectal carcinoma The Christie NHS Foundation Trust Terminated No outcome recorded
Phase 1 NCT01131234 May 2010 → Sep 2014 adult anaplastic ependymoma, adult brainstem glioma, adult glioblastoma, anaplastic astrocytoma +15 National Cancer Institute (NCI) Completed No outcome recorded
Phase 1 NCT00979862 Mar 2010 → May 2012 adult glioblastoma, giant cell glioblastoma, gliosarcoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 1 NCT01065662 Feb 2010 → Sep 2013 cervical cancer, endometrial cancer, fallopian tube cancer, ovarian cancer +1 Susana M. Campos, MD Completed No outcome recorded
Phase 1 NCT00981721 Sep 2009 → May 2010 high grade malignant neoplasm AstraZeneca Completed No outcome recorded
Phase 1 NCT00937482 Aug 2009 → Mar 2011 male breast carcinoma, malignant colon neoplasm, melanoma, metastatic malignant neoplasm in the brain +3 National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT00960349 Aug 2009 → Jan 2010 gastric cancer AstraZeneca Completed No outcome recorded
Phase 1 NCT00750841 Sep 2008 → Jul 2009 overdue cancer AstraZeneca Active not recruiting No outcome recorded
Phase 1 NCT00750425 Aug 2008 → Apr 2009 cancer AstraZeneca Completed No outcome recorded
Phase 1/25 trials
Phase 1/2 NCT02484404 Jun 2015 → Oct 2027 expected breast cancer, colorectal cancer National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 1/2 NCT01208051 Sep 2010 → Feb 2020 thyroid Hurthle cell carcinoma, thyroid gland papillary carcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 1/2 NCT01116648 Apr 2010 → Oct 2018 overdue fallopian tube carcinoma, ovarian endometrioid adenocarcinoma, ovarian serous surface papillary adenocarcinoma, primary peritoneal serous adenocarcinoma +1 National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 1/2 NCT01064648 Mar 2010 → Jun 2018 overdue malignant epithelioid mesothelioma, malignant pleural mesothelioma, sarcomatoid mesothelioma National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 1/2 NCT00662506 Apr 2008 → Apr 2014 adult glioblastoma, giant cell glioblastoma, gliosarcoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 254 trials
Phase 2 NCT04739800 Jun 2021 → Jan 2023 overdue fallopian tube clear cell adenocarcinoma, fallopian tube endometrioid adenocarcinoma, fallopian tube mucinous adenocarcinoma, fallopian tube serous adenocarcinoma +9 National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 2 NCT04090567 Jul 2020 → Dec 2027 expected BRCA1-related cancer predisposition, BRCA2-related cancer predisposition, Her2-receptor negative breast cancer M.D. Anderson Cancer Center Recruiting No outcome recorded
Phase 2 NCT03741426 Jul 2020 → Nov 2025 renal cell carcinoma CCTU- Cancer Theme Unknown No outcome recorded
Phase 2 NCT04184518 May 2020 → Dec 2021 metastatic malignant neoplasm, uveal melanoma Spanish Melanoma Group Withdrawn No outcome recorded
Phase 2 NCT03851614 Apr 2019 → Jan 2027 expected colorectal cancer, leiomyosarcoma, pancreatic adenocarcinoma University Health Network, Toronto Active not recruiting No outcome recorded
Phase 2 NCT03699449 Nov 2018 → Sep 2022 Yonsei University Unknown No outcome recorded
Phase 2 NCT03660826 Sep 2018 → Dec 2024 overdue endometrial endometrioid adenocarcinoma, endometrial mixed adenocarcinoma, endometrial serous adenocarcinoma, endometrial undifferentiated carcinoma National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 2 NCT03570437 May 2018 → Jan 2023 carcinosarcoma, endometrial cancer University of Manchester Unknown No outcome recorded
Phase 2 NCT07648745 May 2018 → Jan 2025 fallopian tube carcinoma, intestinal obstruction, ovarian carcinoma, primary peritoneal carcinoma Prof Gordon Jayson Completed No outcome recorded
Phase 2 NCT02899728 Mar 2018 → Mar 2020 small cell lung carcinoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 2/34 trials
Phase 2/3 NCT02502266 May 2016 → Jun 2023 overdue fallopian tube clear cell adenocarcinoma, fallopian tube endometrioid adenocarcinoma, fallopian tube serous adenocarcinoma, fallopian tube transitional cell carcinoma +7 National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 2/3 NCT00939848 Apr 2011 → Sep 2012 biliary tract neoplasm University College, London Completed No outcome recorded
Phase 2/3 NCT00384176 Aug 2006 → Nov 2009 colorectal cancer AstraZeneca Completed No outcome recorded
Phase 2/3 NCT00245154 Nov 2005 → Jul 2008 lung cancer NCIC Clinical Trials Group Completed No outcome recorded
Phase 35 trials
Phase 3 NCT03278717 Jun 2018 → Dec 2023 ovarian cancer University College, London Unknown No outcome recorded
Phase 3 NCT02446600 Mar 2016 → Feb 2020 overdue fallopian tube clear cell adenocarcinoma, fallopian tube transitional cell carcinoma, ovarian clear cell adenocarcinoma, ovarian endometrioid adenocarcinoma +5 National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 3 NCT00795340 Feb 2009 → Jan 2012 lung cancer NCIC Clinical Trials Group Completed No outcome recorded
Phase 3 NCT00777153 Oct 2008 → Apr 2010 glioblastoma AstraZeneca Completed No outcome recorded
Phase 3 NCT00399035 Nov 2006 → Mar 2010 colorectal cancer AstraZeneca Completed No outcome recorded
Phase not applicable2 trials
NCT02681237 Apr 2016 → Jan 2022 ovarian cancer University Health Network, Toronto Completed No outcome recorded
NCT00310089 Jan 2006 → Jul 2007 breast cancer National Cancer Institute (NCI) Completed No outcome recorded
Also used as a comparator or background therapy in 6 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT02855697 Background May 2017 → Dec 2021 ovarian cancer The Christie NHS Foundation Trust Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT00494221 Comparator Jun 2007 → Oct 2009 colorectal cancer AstraZeneca Completed No outcome recorded
Phase 23 trials
Phase 2 NCT04487587 Comparator Oct 2018 → Mar 2025 overdue cervical cancer The Clatterbridge Cancer Centre NHS Foundation Trust Active not recruiting No outcome recorded
Phase 2 NCT01310855 Comparator May 2011 → May 2013 glioblastoma University College, London Terminated No outcome recorded
Phase 2 NCT01262612 Comparator Apr 2010 → Dec 2011 peritoneal neoplasm, pleural neoplasm Radboud University Medical Center Terminated No outcome recorded
Phase 31 trial
Phase 3 NCT00532194 Comparator Jul 2007 → Apr 2013 ovarian cancer Medical Research Council Unknown No outcome recorded

Evidence & citations 13 cited values

Every value below carries the sentence it was read from. 108 sources stand behind the page.

FieldValueCited text
Known as cediranib Cediranib (RECENTIN™, AZD2171)” NCT00621361
82

NCT00243074

NCT01229930

NCT00310089

NCT00326599

NCT04487587

NCT02899728

NCT03570437

NCT01337401

NCT01391962

NCT00326664

NCT02340611

NCT01132820

NCT00662506

NCT00309946

NCT03314740

NCT00245063

NCT00245154

NCT02484404

NCT03699449

NCT02974621

NCT01364051

NCT00588900

NCT00275028

NCT00303862

NCT00410904

NCT04739800

NCT02345265

NCT00960349

NCT01064648

NCT02681237

NCT02446600

NCT01065662

NCT01160926

NCT02502266

NCT04090567

NCT02889900

NCT00384176

NCT00326872

NCT02893917

NCT07648745

NCT00227760

NCT00243061

NCT00503204

NCT01310855

NCT00427973

NCT00321724

NCT00475150

NCT00795340

NCT03117933

NCT03334617

NCT00750841

NCT04184518

NCT00748891

NCT00423332

NCT00321581

NCT00343408

NCT00458978

NCT01208051

NCT01116648

NCT03660826

NCT01262612

NCT00244881

NCT00527124

NCT00305656

NCT01131234

NCT03851614

NCT00981721

NCT00306891

NCT00777153

NCT00107250

NCT00399035

NCT01260688

NCT00238394

NCT02855697

NCT02498613

NCT00750425

NCT03278717

NCT00278343

NCT03741426

NCT00532194

NCT00937482

NCT00939848

Known as AZD-2171 MALEATE ChEMBL registry synonym — accepted as the source's own label CHEMBL491473
Known as AZD2171 “A Phase III, Randomised, Parallel Group, Multi-Centre Study in Recurrent Glioblastoma Patients to Compare the Efficacy of Cediranib [RECENTIN™, AZD2171] Monotherapy and the...” NCT00777153
23

“Cediranib (AZD2171) Plus Gefitinib (Iressa, ZD1839) With Cediranib Plus Placebo” NCT01310855

“Single Oral Dose of Cediranib (AZD2171, Recentin™)” NCT00306891

“cediranib (RECENTIN TM, AZD2171)” NCT00750425

“cediranib (RECENTIN TM, AZD2171)” NCT00981721

“Cediranib (RECENTIN™, AZD2171)” NCT00621361

NCT00436956

NCT00502567

NCT00502164

NCT00264004

NCT00502060

NCT00385203

NCT00621725

NCT00494221

NCT00503412

NCT00539331

NCT00502385

NCT00503477

NCT00475956

NCT00501605

NCT00243347

NCT00278889

NCT00942877

NCT00454805

Known as Cediranib maleat ChEMBL registry synonym — accepted as the source's own label CHEMBL491473
Known as cediranib maleate “This phase II trial studies cediranib maleate in combination with olaparib in treating patients with solid tumors that have spread to other parts of the body...” NCT02498613
12

“This phase I trial is studying the side effects and best dose of cediranib maleate when given together with whole brain radiation therapy in treating patients with brain...” NCT00937482

“AZD2171 (cediranib maleate) may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.” NCT00238394

“To assess the activity of cediranib (cediranib maleate) in patients with either persistent or recurrent endometrial carcinoma.” NCT01132820

Cediranib Maleate and Selumetinib Sulfate in Treating Patients With Solid Malignancies” NCT01364051

“Patients will receive AZD2171 (cediranib maleate) 30mg by mouth once a day.” NCT00427973

“Patients receive olaparib PO BID and cediranib maleate PO once daily (QD).” NCT02446600

“Drug: cediranib maleateNCT00588900

“Drug: Cediranib MaleateNCT02974621

NCT00458731

NCT01229111

NCT01062425

NCT00979862

Known as RECENTIN “A Phase III, Randomised, Parallel Group, Multi-Centre Study in Recurrent Glioblastoma Patients to Compare the Efficacy of Cediranib [RECENTIN™, AZD2171] Monotherapy and the...” NCT00777153
2

“Cediranib, AZD2171, RECENTINNCT00321581

Recentin (Cediranib)” NCT00748891

Known as RECENTIN TM “cediranib (RECENTIN TM, AZD2171)” NCT00750425
1

“cediranib (RECENTIN TM, AZD2171)” NCT00981721

Known as RECENTINÔ “Multiple Oral Doses of Cediranib (AZD2171, RECENTINÔ), in Patients With Advanced Solid Tumours” NCT00750425
Known as ZD-2171 ChEMBL registry synonym — accepted as the source's own label CHEMBL491473
Action Inhibit “Cediranib maleate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.” NCT00227760
Modality Small molecule “Cediranib, an oral pan-VEGF receptor tyrosine kinase inhibitor” PMID 20458050 May 2010
Route Oral “Given daily; orally with approximately 240 ml of water whilst in an upright position” NCT00107250
Target KIT “activity against all three VEGF receptors and KITPMID 24714778 Apr 2014