Drugs / Nemtabrutinib

Trials 26

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 111 trials
Phase 1 NCT07734610 Sep 2026 → Feb 2027 expected — Merck Sharp & Dohme LLC Recruiting No outcome recorded
Phase 1 NCT07232589 Dec 2025 → May 2026 — Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06442436 Jul 2024 → Aug 2026 — Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06625827 Nov 2023 → Jan 2024 — Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06688045 Oct 2023 → Jan 2024 — Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06772818 Oct → Dec 2023 — Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06586671 Aug → Nov 2023 hematopoietic and lymphoid cell neoplasm Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06698016 Jul → Oct 2023 — Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06772805 Jul → Dec 2023 — Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT05673460 Feb 2023 → Apr 2025 neoplasm of mature B-cells Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT03162536 Jun 2017 → Sep 2027 expected Richter transformation, Waldenstrom macroglobulinemia, chronic lymphocytic leukemia/small lymphocytic lymphoma, diffuse large B-cell lymphoma +3 ArQule, Inc. Active not recruiting No outcome recorded
Phase 211 trials
Phase 2 NCT07583810 Dec 2026 → May 2028 expected gastric mucosa-associated lymphoid tissue lymphoma, nodal marginal zone B-cell lymphoma, primary lymphoma of the conjunctiva, splenic marginal zone lymphoma City of Hope Medical Center Recruiting No outcome recorded
Phase 2 NCT06863402 Nov 2026 → Jun 2029 expected B-cell chronic lymphocytic leukemia, Richter transformation, diffuse large B-cell lymphoma Roswell Park Cancer Institute Recruiting No outcome recorded
Phase 2 NCT07194980 Oct 2026 → Oct 2029 expected chronic lymphocytic leukemia/small lymphocytic lymphoma Fred Hutchinson Cancer Center Recruiting No outcome recorded
Phase 2 NCT07796373 Oct 2026 → Dec 2030 expected chronic lymphocytic leukemia/small lymphocytic lymphoma National Heart, Lung, and Blood Institute (NHLBI) Not yet recruiting No outcome recorded
Phase 2 NCT07690891 Oct 2026 → Dec 2029 expected chronic lymphocytic leukemia/small lymphocytic lymphoma Medical College of Wisconsin Not yet recruiting No outcome recorded
Phase 2 NCT07557056 Sep 2026 → Dec 2027 expected chronic lymphocytic leukemia/small lymphocytic lymphoma Jennifer Woyach Not yet recruiting No outcome recorded
Phase 2 NCT07673367 Jul 2026 → Jul 2031 expected mantle cell lymphoma Vanderbilt-Ingram Cancer Center Not yet recruiting No outcome recorded
Phase 2 NCT07464210 Jun 2026 → Aug 2029 expected Waldenstrom macroglobulinemia Seoul National University Hospital Not yet recruiting No outcome recorded
Phase 2 NCT06572618 Jan 2025 → Jan 2027 expected mantle cell lymphoma City of Hope Medical Center Recruiting No outcome recorded
Phase 2 NCT05458297 Jul 2022 → May 2029 expected B-cell chronic lymphocytic leukemia, Richter transformation, follicular lymphoma, mantle cell lymphoma Merck Sharp & Dohme LLC Active not recruiting No outcome recorded
Phase 33 trials
Phase 3 NCT06136559 Dec 2023 → Sep 2032 expected chronic lymphocytic leukemia/small lymphocytic lymphoma Merck Sharp & Dohme LLC Recruiting No outcome recorded
Phase 3 NCT05947851 Aug 2023 → Jun 2032 expected chronic lymphocytic leukemia/small lymphocytic lymphoma Merck Sharp & Dohme LLC Recruiting No outcome recorded
Phase 3 NCT05624554 Mar 2023 → May 2027 expected chronic lymphocytic leukemia/small lymphocytic lymphoma Merck Sharp & Dohme LLC Active not recruiting No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 28 sources stand behind the page.

FieldValueCited text
Known as Nemtabrutinib “This is a phase II (2 parts), open-label, single arm, multicenter study to evaluate the efficacy and safety of nemtabrutinib in combination with bortezomib and rituximab” NCT07464210 ↗
25

NCT06625827 ↗

NCT06772805 ↗

NCT06586671 ↗

NCT05673460 ↗

NCT05624554 ↗

NCT07734610 ↗

NCT06572618 ↗

NCT05947851 ↗

NCT07194980 ↗

NCT05458297 ↗

Show 15 more sources

Known as ARQ-531 ChEMBL registry synonym — accepted as the source's own label CHEMBL4756476 ↗
Known as MK-1026 ChEMBL registry synonym — accepted as the source's own label CHEMBL4756476 ↗
Action Inhibit “reversible inhibitor of Bruton tyrosine kinase (BTK)” PMID 37930156 ↗ Jan 2024
Modality Other / unclassified “Nemtabrutinib is in a class of medications called kinase inhibitors.” NCT06863402 ↗
Route Oral “Nemtabrutinib will be orally administered once per day under fasted conditions” NCT03162536 ↗
Target BTK “Nemtabrutinib is an orally bioavailable, reversible inhibitor of Bruton tyrosine kinase (BTK) and C481S mutant BTK.” PMID 37930156 ↗ Jan 2024