Drugs / Nemtabrutinib

Trials 24 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 110 trials
Phase 1 NCT07232589 Dec 2025 → May 2026 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06442436 Jul 2024 → Sep 2026 expected Merck Sharp & Dohme LLC Recruiting No outcome recorded
Phase 1 NCT06625827 Nov 2023 → Jan 2024 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06688045 Oct 2023 → Jan 2024 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06772818 Oct → Dec 2023 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06586671 Aug → Nov 2023 hematopoietic and lymphoid cell neoplasm Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06698016 Jul → Oct 2023 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06772805 Jul → Dec 2023 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT05673460 Feb 2023 → Apr 2025 neoplasm of mature B-cells Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT05347225 Jun 2022 → Apr 2027 expected hematopoietic and lymphoid cell neoplasm Merck Sharp & Dohme LLC Active not recruiting No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT03162536 Jun 2017 → Sep 2027 expected Richter transformation, Waldenstrom macroglobulinemia, chronic lymphocytic leukemia/small lymphocytic lymphoma, diffuse large B-cell lymphoma +3 ArQule, Inc. Active not recruiting No outcome recorded
Phase 210 trials
Phase 2 NCT07583810 Dec 2026 → May 2028 expected gastric mucosa-associated lymphoid tissue lymphoma, nodal marginal zone B-cell lymphoma, primary lymphoma of the conjunctiva, splenic marginal zone lymphoma City of Hope Medical Center Not yet recruiting No outcome recorded
Phase 2 NCT07690891 Oct 2026 → Dec 2029 expected chronic lymphocytic leukemia/small lymphocytic lymphoma Medical College of Wisconsin Not yet recruiting No outcome recorded
Phase 2 NCT07557056 Sep 2026 → Dec 2027 expected chronic lymphocytic leukemia/small lymphocytic lymphoma Jennifer Woyach Not yet recruiting No outcome recorded
Phase 2 NCT06863402 Aug 2026 → Jun 2029 expected B-cell chronic lymphocytic leukemia, Richter transformation, diffuse large B-cell lymphoma Roswell Park Cancer Institute Recruiting No outcome recorded
Phase 2 NCT07194980 Aug 2026 → Oct 2029 expected chronic lymphocytic leukemia/small lymphocytic lymphoma Fred Hutchinson Cancer Center Recruiting No outcome recorded
Phase 2 NCT07673367 Jul 2026 → Jul 2031 expected mantle cell lymphoma Vanderbilt-Ingram Cancer Center Not yet recruiting No outcome recorded
Phase 2 NCT07464210 Jun 2026 → Aug 2029 expected Waldenstrom macroglobulinemia Seoul National University Hospital Not yet recruiting No outcome recorded
Phase 2 NCT06572618 Jan 2025 → Jan 2027 expected mantle cell lymphoma City of Hope Medical Center Recruiting No outcome recorded
Phase 2 NCT05458297 Jul 2022 → May 2029 expected B-cell chronic lymphocytic leukemia, Richter transformation, follicular lymphoma, mantle cell lymphoma Merck Sharp & Dohme LLC Active not recruiting No outcome recorded
Phase 2 NCT04728893 Apr 2021 → Jan 2029 expected Waldenstrom macroglobulinemia, chronic lymphocytic leukemia/small lymphocytic lymphoma Merck Sharp & Dohme LLC Recruiting No outcome recorded
Phase 33 trials
Phase 3 NCT06136559 Dec 2023 → Sep 2032 expected chronic lymphocytic leukemia/small lymphocytic lymphoma Merck Sharp & Dohme LLC Recruiting No outcome recorded
Phase 3 NCT05947851 Aug 2023 → Jun 2032 expected chronic lymphocytic leukemia/small lymphocytic lymphoma Merck Sharp & Dohme LLC Recruiting No outcome recorded
Phase 3 NCT05624554 Mar 2023 → May 2027 expected chronic lymphocytic leukemia/small lymphocytic lymphoma Merck Sharp & Dohme LLC Active not recruiting No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 26 sources stand behind the page.

FieldValueCited text
Known as Nemtabrutinib “This is a phase II (2 parts), open-label, single arm, multicenter study to evaluate the efficacy and safety of nemtabrutinib in combination with bortezomib and rituximab” NCT07464210
23

NCT06688045

NCT06572618

NCT06136559

NCT05458297

NCT06442436

NCT05947851

NCT05673460

NCT07232589

NCT06772805

NCT05347225

NCT06586671

NCT07583810

NCT05624554

NCT07194980

NCT03162536

NCT06698016

NCT06625827

NCT07690891

NCT06863402

NCT06772818

NCT07557056

NCT04728893

NCT07673367

Known as ARQ-531 ChEMBL registry synonym — accepted as the source's own label CHEMBL4756476
Known as MK-1026 ChEMBL registry synonym — accepted as the source's own label CHEMBL4756476
Action Inhibit “reversible inhibitor of Bruton tyrosine kinase (BTK)” PMID 37930156 Jan 2024
Modality Other / unclassified “Nemtabrutinib is in a class of medications called kinase inhibitors.” NCT06863402
Route Oral “Nemtabrutinib will be orally administered once per day under fasted conditions” NCT03162536
Target BTK “Nemtabrutinib is an orally bioavailable, reversible inhibitor of Bruton tyrosine kinase (BTK) and C481S mutant BTK.” PMID 37930156 Jan 2024