Drugs / Ganetespib
last change Sep 2023 re-read 2 minutes ago

Ganetespib

also known as STA-9090 · gantespib

Small molecule

Developed for
acute myeloid leukemia · HER2 positive breast carcinoma · non-small cell lung carcinoma · primary peritoneal carcinoma · breast cancer · cancer · fallopian tube cancer · malignant epithelial tumor of ovary
+31 more · myelodysplastic syndrome · prostate adenocarcinoma · rectal cancer · small cell lung carcinoma · triple-negative breast carcinoma · acute lymphoblastic leukemia · blast phase chronic myelogenous leukemia, BCR-ABL1 positive · chronic myeloid leukemia · fallopian tube carcinoma · gastroesophageal cancer · gastroesophageal junction adenocarcinoma · gastrointestinal stromal tumor · hepatocellular carcinoma · hormone-resistant prostate carcinoma · hypopharynx squamous cell carcinoma · laryngeal squamous cell carcinoma · lung adenocarcinoma · lung cancer · male breast carcinoma · malignant neoplasm of cervical esophagus · malignant neoplasm of thoracic esophagus · malignant peripheral nerve sheath tumor · malignant pleural mesothelioma · melanoma · neoplasm · ocular melanoma · oral cavity squamous cell carcinoma · oropharynx squamous cell carcinoma · ovarian cancer · pancreatic adenocarcinoma · plasma cell myeloma
Investigated by
Synta Pharmaceuticals Corp. · National Cancer Institute (NCI) · Beth Israel Deaconess Medical Center · Dana-Farber Cancer Institute · Massachusetts General Hospital · Memorial Sloan Kettering Cancer Center
+23 more · Emory University · European Commission · Barbara Ann Karmanos Cancer Institute · Brigham and Women's Hospital · Cancer Research UK · Cardiff University · David M. Jackman, MD · Experimental Cancer Medicine Centres · Fox Chase Cancer Center · Georgetown University · Leukaemia Lymphoma Research · M.D. Anderson Cancer Center · Medical University Innsbruck · Multiple Myeloma Research Consortium · New York University Cancer Institute · QuantumLeap Healthcare Collaborative · Sarcoma Alliance for Research through Collaboration · Toni Choueiri, MD · United States Department of Defense · Universitaire Ziekenhuizen KU Leuven · University College, London · University of Chicago · Vanderbilt-Ingram Cancer Center

Trials 37 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 113 trials
Phase 1 NCT02389751 Apr 2015 → Jul 2019 gastroesophageal junction adenocarcinoma, malignant neoplasm of cervical esophagus, malignant neoplasm of thoracic esophagus M.D. Anderson Cancer Center Completed No outcome recorded
Phase 1 NCT02192541 Dec 2014 → Feb 2016 neoplasm National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT02334319 Dec 2014 → Feb 2016 hypopharynx squamous cell carcinoma, laryngeal squamous cell carcinoma, oral cavity squamous cell carcinoma, oropharynx squamous cell carcinoma Emory University Terminated No outcome recorded
Phase 1 NCT02060253 Apr 2014 → Jun 2018 HER2 positive breast carcinoma, male breast carcinoma Memorial Sloan Kettering Cancer Center Completed No outcome recorded
Phase 1 NCT01554969 May 2012 → Mar 2015 rectal cancer Emory University Completed No outcome recorded
Phase 1 NCT01579994 Apr 2012 → Dec 2020 lung cancer Memorial Sloan Kettering Cancer Center Completed No outcome recorded
Phase 1 NCT01485835 Jan 2012 → Sep 2015 plasma cell myeloma Emory University Completed No outcome recorded
Phase 1 NCT01665937 Aug 2010 → Jul 2013 hepatocellular carcinoma Massachusetts General Hospital Completed No outcome recorded
Phase 1 NCT01183364 Jul 2010 → Mar 2013 Synta Pharmaceuticals Corp. Completed No outcome recorded
Phase 1 NCT00964873 Aug 2009 → Dec 2010 acute lymphoblastic leukemia, acute myeloid leukemia, blast phase chronic myelogenous leukemia, BCR-ABL1 positive Synta Pharmaceuticals Corp. Completed No outcome recorded
Phase 1/26 trials
Phase 1/2 NCT02261805 Oct 2014 → Oct 2016 small cell lung carcinoma Georgetown University Terminated No outcome recorded
Phase 1/2 NCT02012192 Jul 2014 → Nov 2017 fallopian tube carcinoma, malignant epithelial tumor of ovary, primary peritoneal carcinoma Medical University Innsbruck Terminated No outcome recorded
Phase 1/2 NCT02008877 Dec 2013 → Apr 2018 malignant peripheral nerve sheath tumor Sarcoma Alliance for Research through Collaboration Completed No outcome recorded
Phase 1/2 NCT01962948 Oct 2013 → May 2016 fallopian tube cancer, malignant epithelial tumor of ovary, primary peritoneal carcinoma Fox Chase Cancer Center Terminated No outcome recorded
Phase 1/2 NCT01590160 Aug 2013 → Nov 2019 malignant pleural mesothelioma University College, London Completed No outcome recorded
Phase 1/2 NCT01236144 Apr 2011 → Dec 2013 acute myeloid leukemia, myelodysplastic syndrome Cardiff University Completed No outcome recorded
Phase 215 trials
Phase 2 NCT03783949 Nov 2018 → Sep 2023 fallopian tube cancer, ovarian cancer, primary peritoneal carcinoma Universitaire Ziekenhuizen KU Leuven Completed No outcome recorded
Phase 2 NCT01677455 Jul 2012 → Apr 2015 HER2 positive breast carcinoma, triple-negative breast carcinoma Synta Pharmaceuticals Corp. Completed No outcome recorded
Phase 2 NCT01562015 Apr 2012 → Aug 2014 non-small cell lung carcinoma Synta Pharmaceuticals Corp. Completed No outcome recorded
Phase 2 NCT01551693 Sep 2011 → Sep 2012 melanoma Dana-Farber Cancer Institute Terminated No outcome recorded
Phase 2 NCT01368003 Apr 2011 → Nov 2012 prostate adenocarcinoma Toni Choueiri, MD Withdrawn No outcome recorded
Phase 2 NCT01273896 Jan 2011 → Sep 2013 breast cancer Memorial Sloan Kettering Cancer Center Completed No outcome recorded
Phase 2 NCT01270880 Jan 2011 → Jul 2014 hormone-resistant prostate carcinoma, prostate adenocarcinoma Barbara Ann Karmanos Cancer Institute Completed No outcome recorded
Phase 2 NCT01227018 Dec 2010 → May 2013 pancreatic adenocarcinoma Vanderbilt-Ingram Cancer Center Terminated No outcome recorded
Phase 2 NCT01200238 Sep 2010 → Oct 2014 ocular melanoma Dana-Farber Cancer Institute Completed No outcome recorded
Phase 2 NCT01167114 Aug 2010 → May 2016 gastroesophageal cancer Massachusetts General Hospital Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT01348126 May 2011 → Apr 2014 non-small cell lung carcinoma Synta Pharmaceuticals Corp. Terminated No outcome recorded
Phase 31 trial
Phase 3 NCT01798485 Apr 2013 → Dec 2015 lung adenocarcinoma Synta Pharmaceuticals Corp. Terminated No outcome recorded
Phase not applicable1 trial
NCT02637375 May 2016 → Dec 2018 breast cancer University of Chicago Withdrawn No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 2 NCT01560416 Comparator Jun 2012 → Jun 2016 breast cancer Dana-Farber Cancer Institute Completed No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 40 sources stand behind the page.

FieldValueCited text
Known as ganetespib “once weekly administration of the Hsp90 inhibitor ganetespib (STA-9090)” PMID 23530663 Mar 2013
27

“STA-9090 (ganetespib) with Docetaxel” NCT01183364

“STA-9090 (ganetespib)” NCT00964873

“STA-9090 (ganetespib)” NCT00858572

“STA-9090 (ganetespib)” NCT01031225

NCT01348126

NCT01236144

NCT01579994

NCT01562015

NCT01560416

NCT01042379

NCT01962948

NCT02012192

NCT01590160

NCT02637375

NCT00688116

NCT03783949

NCT01798485

NCT02008877

NCT01485835

NCT01039519

NCT01677455

NCT02334319

NCT02060253

NCT02192541

NCT02261805

NCT01554969

NCT02389751

Known as gantespib “Subsequent cohorts will receive higher amounts of STA-9090 (gantespib)” NCT00687934
Known as STA-9090 “The purpose of this study is to determine if ganetespib (STA-9090) is effective in the treatment of patients with HER2+ or triple negative breast cancer who have not received...” NCT01677455
20

“An open-label dose escalation study of patients with solid tumors treated with STA-9090 (ganetespib)” NCT00688116

“Study of Ganetespib (STA-9090) + Docetaxel in Advanced Non Small Cell Lung Cancer” NCT01348126

“Ganetespib (STA-9090) is given intravenously (days 1 and 8 of a 21 day cycle).” NCT01579994

“once weekly administration of the Hsp90 inhibitor ganetespib (STA-9090)” PMID 23530663 Mar 2013

“Patients will start on ganetespib (STA9090) at a set dose level.” NCT01554969

STA-9090 (ganetespib)” NCT01031225

NCT00964873

NCT01167114

NCT01183364

NCT01368003

NCT00858572

NCT01200238

NCT00687934

NCT01227018

NCT01270880

NCT01111838

NCT01273896

NCT01173523

NCT01551693

NCT01665937

Action Inhibit “the HSP90 Inhibitor, STA-9090” NCT00687934
Modality Small molecule “Ganetespib which is a novel triazolone heterocyclic inhibitor of HSP90” PMID 31898183 Jan 2020
Route Intravenous “given as 1 hour IV infusion” PMID 23530663 Mar 2013