drugset / Trial / NCT01962948

Paclitaxel and Ganetespib in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

NCT01962948

Non-randomizedSequentialOpen-labelTreatment

Summary

This phase I/II trial studies the side effects and best dose of ganetespib when given together with paclitaxel and to see how well they work in treating patients with recurrent ovarian, fallopian tube, or primary peritoneal cancer. Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Ganetespib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving paclitaxel and ganetespib may be an effective treatment for ovarian, fallopian tube, or primary peritoneal cancer.

Timeline

Start
2013-10-09
Primary completion
2016-05-09
Completion
2018-07-06

Drugs

EvaluationDrugModalityDoseRoute
Subject Ganetespib Small molecule 100 mg/m2 Intravenous
Subject Ganetespib Small molecule 125 mg/m2 Intravenous
Subject Ganetespib Small molecule 150 mg/m2 Intravenous
Subject Paclitaxel Small molecule 80 mg/m2 Intravenous