Drugs / Interferon alfa-2a

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Refused (EMA) EU (EMA) Alpheon — 2006-09-05 europa.eu ↗

Trials 23

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 15 trials
Phase 1 NCT00000967 ? → Sep 1996 HIV infectious disease National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1 NCT00000764 ? → Jul 1996 HIV infectious disease, anus neoplasm National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1 NCT00001113 ? → Mar 1990 HIV infectious disease, Kaposi's sarcoma National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1 NCT00000725 ? → Feb 1990 HIV infectious disease, Kaposi's sarcoma National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1 NCT00000696 ? → Nov 1993 HIV infectious disease National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1/23 trials
Phase 1/2 NCT04072263 Aug 2018 → Aug 2021 ovarian carcinoma Leiden University Medical Center Unknown No outcome recorded
Phase 1/2 NCT01997944 Nov 2013 → Sep 2014 chronic hepatitis B virus infection Beijing Bio-Fortune Ltd. Completed No outcome recorded
Phase 1/2 NCT01513187 Jul 2011 → Dec 2015 renal cell carcinoma Spanish Oncology Genito-Urinary Group Completed No outcome recorded
Phase 29 trials · 1 met primary
Phase 2 NCT00796757 Dec 2008 → Feb 2012 renal cell carcinoma Hoffmann-La Roche Completed No outcome recorded
Phase 2 NCT00508040 Sep 2007 → Oct 2011 birdshot chorioretinopathy, cystoid macular edema Assistance Publique - Hôpitaux de Paris Completed No outcome recorded
Phase 2 NCT02159482 Nov 2005 → May 2008 cancer Duke University Terminated No outcome recorded Stop: Enrollment
Phase 2 NCT00323505 Mar 2001 → Dec 2004 plasma cell myeloma Royal Marsden NHS Foundation Trust Completed No outcome recorded
Phase 2 NCT00008463 Nov 2000 → Aug 2006 HIV infectious disease, hepatitis C virus infection National Institute of Allergy and Infectious Diseases (NIAID) Completed Met primary
Phase 2 NCT00003172 Dec 1997 → Sep 2004 gastric cancer Eastern Cooperative Oncology Group Completed No outcome recorded
Phase 2 NCT00001567 Jan 1997 → Apr 2002 hairy cell leukemia National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT00000754 ? → Feb 1995 HIV infectious disease National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 2 NCT00000687 ? → Jul 1993 HIV infectious disease, Kaposi's sarcoma National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 35 trials · 3 missed
Phase 3 NCT03209219 Jun 2017 → Aug 2020 Behcet disease, uveitis Peking Union Medical College Hospital Completed No outcome recorded
Phase 3 NCT00002892 Oct 1995 → Dec 2001 cutaneous melanoma Institute of Cancer Research, United Kingdom Completed Missed primary
Phase 3 NCT00483132 Sep 1994 → Apr 2002 acute lymphoblastic leukemia French Innovative Leukemia Organisation Completed No outcome recorded
Phase 3 NCT00502034 Jul 1994 → Apr 2007 renal cell carcinoma Italian Oncology Group for Clinical Research Completed Missed primary
Phase 3 NCT00416429 ? → Feb 2005 kidney cancer Centre Leon Berard Completed Missed primary
Phase 41 trial
Phase 4 NCT00502970 May 2004 → Nov 2007 hepatitis C virus infection Aga Khan University Completed No outcome recorded
Comparator or background therapy14 trials
Phase 2 NCT02340962 Background May 2015 → Aug 2016 chronic hepatitis C virus infection TaiGen Biotechnology Co., Ltd. Completed No outcome recorded
Phase 2 NCT00719264 Comparator Nov 2008 → Dec 2011 renal cell carcinoma Novartis Pharmaceuticals Completed Missed primary
Phase 2 NCT00619268 Comparator Feb 2008 → Feb 2012 renal cell carcinoma Centre Leon Berard Completed Missed primary
Phase 2 NCT00520403 Background Sep 2007 → Mar 2010 renal cell carcinoma Hoffmann-La Roche Completed No outcome recorded
Phase 2 NCT00433069 Background Jan → Dec 2007 chronic hepatitis C virus infection University Hospital, Geneva Completed No outcome recorded

Press releases naming this drug 8 releases

DateIssuerRelease
2018-11-20 Ascletis Pharmaceuticals Co., Ltd. Ascletis and Roche Enter Exclusive Pegasys Partnership in China for Viral Hepatitis ascletis.com ↗
2012-02-23 Vertex Pharmaceuticals Incorporated Vertex Announces 12-Week On-Treatment Data and SVR4 From Phase 2 Study of Interferon-Free (All-Oral) Treatment Regimen of INCIVEK®, VX-222 and Ribavirin in People with Genotype 1 Hepatitis C vrtx.com ↗
2011-03-31 Vertex Pharmaceuticals Incorporated Interim Phase 2 Data Showed Rapid Viral Response to VX-222 in Combination with Telaprevir, Pegylated-Interferon and Ribavirin Among People With Hepatitis C vrtx.com ↗
2011-02-18 Medivir The phase 3 program for TMC435 in treatment-naïve patients and patients who have relapsed after prior interferon-based treatment has now started medivir.com ↗
2010-10-01 Bristol-Myers Squibb ZymoGenetics and Bristol-Myers Squibb to Present PEG-Interferon Lambda Phase 2a Interim Clinical Trial Results at AASLD 2010 bms.com ↗
2006-05-21 Vertex Pharmaceuticals Incorporated Researchers Report Results for 28-day Phase II Study of VX-950 in Combination with Pegylated Interferon and Ribavirin in Hepatitis C Patients vrtx.com ↗
2006-04-29 Vertex Pharmaceuticals Incorporated Researchers Report Initial Results for 14-day Phase Ib Study of VX-950, and Pegylated Interferon, Showing Anti-HCV Activity in Combination in Hepatitis C Patients vrtx.com ↗
2006-01-09 Vertex Pharmaceuticals Incorporated VX-950, Investigational Oral Hepatitis C Protease Inhibitor, Demonstrates Rapid and Dramatic Reduction in Viral Levels in Combination with Pegylated Interferon vrtx.com ↗

Evidence & citations 18 cited values

Every value below carries the sentence it was read from. 37 sources stand behind the page.

FieldValueCited text
Known as Interferon alfa-2a “the effect of interferon alfa-2a (3 megaunits three times per week for 2 years or until recurrence) on overall survival (OS) and recurrence-free survival (RFS) was compared...” PMID 14665609 ↗ Dec 2003
26

“Arm II (recombinant interferon alfa-2a): Patients receive recombinant interferon alfa-2a subcutaneously (SC) 3 times weekly for 12 weeks.” NCT00416429 ↗

“combination treatment with 13-cis-retinoic acid (13-CRA) plus interferon alfa-2a (IFN-alpha-2a) was superior to IFN-alpha-2a alone” PMID 15961764 ↗ Jun 2005

“1.2.1 Interferon Alfa 2a Interferon Alfa was the first drug shown to have bioactivity against HCV.” NCT00502970 ↗

“interferon alfa-2a (IFN-alpha-2a) in patients with untreated, advanced renal cancer.” PMID 19171708 ↗ Jan 2009

NCT00000696 ↗

NCT00308607 ↗

NCT00008463 ↗

NCT03733652 ↗

NCT00796757 ↗

NCT04072263 ↗

Show 16 more sources

Known as Human Serum ALbumin/interferon alpha2a ClinicalTrials.gov intervention name — accepted as the source's own label NCT01997944 ↗
Known as IFN “IFN (Interferon, Peg-interferon alpha-2a or PEGASYS®) is available as a sterile, preservative-free, colorless to light yellow injectable solution administered subcutaneously.” NCT02340962 ↗
1

“bevacizumab, interferon alfa-2a (IFN)” NCT00719264 ↗

Known as IFN alfa-2a “To determine the safety and efficacy of two doses of interferon alfa-2a ( IFN alfa-2a ) in combination with zidovudine ( AZT )/zalcitabine ( ddC ) versus AZT/ddC only in...” NCT00000754 ↗
Known as IFN α2a “This study compares the long-term efficacy and safety of interferon (IFN) α2a and cyclosporine (cyclosporin A, CsA) following suppression of acute attack by high-dose oral...” NCT03209219 ↗
Known as IFN-A2A “To evaluate the anti-HIV effect of single agent versus combination therapy with zidovudine (AZT) and interferon alfa-2a (IFN-A2a), as measured by p24 protein expression, viral...” NCT00000696 ↗
3

“To determine the safety and effectiveness of combining zidovudine (AZT) and interferon alfa-2a (IFN-A2a) in a treatment for Kaposi's sarcoma (KS) in patients who have AIDS.” NCT00000687 ↗

“The two kinds are interferon alpha (IFN-A) and interferon alpha-2A (recombinant) (IFN-A2A).” NCT00001113 ↗

“The two kinds are interferon alpha (IFN-A) and interferon alpha-2A (recombinant) (IFN-A2A).” NCT00000725 ↗

Known as IFN-alpha-2a “combination treatment with 13-cis-retinoic acid (13-CRA) plus interferon alfa-2a (IFN-alpha-2a) was superior to IFN-alpha-2a alone” PMID 15961764 ↗ Jun 2005
1

“interferon alfa-2a (IFN-alpha-2a) in patients with untreated, advanced renal cancer.” PMID 19171708 ↗ Jan 2009

Known as IFNα “Interferon alpha (IFNα) s.c., may work as a low toxic preconditioning regimens” NCT04072263 ↗
Known as Interferon “IFN (Interferon, Peg-interferon alpha-2a or PEGASYS®) is available as a sterile, preservative-free, colorless to light yellow injectable solution administered subcutaneously.” NCT02340962 ↗
Known as interferon alpha-2A (recombinant) “The two kinds are interferon alpha (IFN-A) and interferon alpha-2A (recombinant) (IFN-A2A).” NCT00000725 ↗
Known as Interferon alpha2 a “We propose to analyse the potential therapeutic effect of Interferon alpha2 a versus Steroid therapy with a control group for a 4 months period.” NCT00508040 ↗
8

“interferon-alpha-2a (1), 9 MU given subcutaneously three times per week, once per week for 6 weeks.” PMID 12074329 ↗ May 2002

NCT00204529 ↗

NCT00483132 ↗

NCT00619268 ↗

NCT00323505 ↗

NCT00167583 ↗

NCT01513187 ↗

NCT00508040 ↗

Known as Peg-interferon alpha-2a “IFN (Interferon, Peg-interferon alpha-2a or PEGASYS®) is available as a sterile, preservative-free, colorless to light yellow injectable solution administered subcutaneously.” NCT02340962 ↗
Known as PEGASYS “IFN (Interferon, Peg-interferon alpha-2a or PEGASYS®) is available as a sterile, preservative-free, colorless to light yellow injectable solution administered subcutaneously.” NCT02340962 ↗
1

“PEG-IFN-α2a) (PegasysTM, Roche Pharma Schweiz AG, Reinach, Switzerland) 180 μg QW” NCT00433069 ↗

Known as Roferon “Interferon alfa 2a [Roferon]” NCT00738530 ↗
Known as Roferon-A “The purpose of this study is to determine whether combination therapy with bevacizumab (Avastin), dacarbazine and interferon-alfa-2a (Roferon-A) is effective in patients with...” NCT00308607 ↗
1

NCT00001567 ↗

Action Inhibit “IFN alfa-2a inhibits translation of viral proteins.” NCT00000754 ↗
Modality Protein / enzyme biologic “Recombinant Alpha-2A Interferon” NCT00000687 ↗
Route Subcutaneous “IFN-A2a is administered as a single subcutaneous injection once a day.” NCT00000687 ↗