Drugs / RG4733
last change Aug 2015 re-read 9 days ago

RG4733

also known as RO4929097 · NSC-749225

Small molecule

Developed for
adult glioblastoma · female breast carcinoma · giant cell glioblastoma · gliosarcoma · male breast carcinoma · non-small cell lung carcinoma · Her2-receptor negative breast cancer · adult brainstem glioma
+120 more · anaplastic astrocytoma · anaplastic oligodendroglioma · cancer of unknown primary site · cutaneous melanoma · pancreatic adenocarcinoma · triple-negative breast carcinoma · anaplastic large cell lymphoma · benign meningioma · Burkitt lymphoma · craniopharyngioma · ependymoblastoma · estrogen-receptor positive breast cancer · grade II meningioma · grade III lymphomatoid granulomatosis · Hodgkins lymphoma · neoplasm · ovarian carcinoma · rectal carcinoma · renal cell carcinoma · subependymal giant cell astrocytoma · supratentorial primitive neuroectodermal tumor · acoustic neuroma · acral lentiginous melanoma · adult anaplastic ependymoma · adult brain ependymoma · adult choroid plexus neoplasm · adult epithelioid sarcoma · adult extraskeletal osteosarcoma · adult fibrosarcoma · adult intracranial malignant hemangiopericytoma · adult liposarcoma · adult malignant mesenchymoma · adult medulloblastoma · adult oligodendroglioma · adult papillary meningioma · adult pineoblastoma · alveolar soft part sarcoma · anaplastic ependymoma · anaplastic meningioma · atypical teratoid rhabdoid tumor · brain neoplasm · central nervous system melanocytic neoplasm · central nervous system teratoma · childhood brain stem glioma · childhood central nervous system germinoma · childhood central nervous system mixed germ cell tumor · childhood cerebellar astrocytic neoplasm · childhood cerebral astrocytoma · childhood choroid plexus neoplasm · childhood medulloblastoma · childhood oligodendroglioma · childhood spinal cord tumor · chondrosarcoma · chromophobe adenoma · clear cell renal carcinoma · clear cell sarcoma of kidney · colon adenocarcinoma · colon carcinoma · colon mucinous adenocarcinoma · colon signet ring cell adenocarcinoma · dermatofibrosarcoma protuberans · desmoplastic small round cell tumor · diffuse astrocytoma · endometrial carcinoma · endometrial serous adenocarcinoma · epithelioid hemangioendothelioma · Ewing sarcoma/peripheral primitive neuroectodermal tumor · exocrine pancreatic carcinoma · extraskeletal myxoid chondrosarcoma · fallopian tube carcinoma · gastrointestinal stromal tumor · grade III meningioma · HER2 positive breast carcinoma · Kaposi's sarcoma · lentigo maligna melanoma · lymphoma · malignant colon neoplasm · malignant peripheral nerve sheath tumor · medulloepithelioma · melanoma · metastasis from malignant tumor of colon · metastatic malignant neoplasm in the brain · mixed glioma · myxopapillary ependymoma · nodular malignant melanoma · optic pathway glioma · osteosarcoma · ovarian germ cell tumor · ovarian sarcoma · pediatric CNS choriocarcinoma · pediatric infratentorial ependymoma · pediatric supratentorial ependymoma · pilocytic astrocytoma · pineal gland astrocytoma · pineoblastoma · pineocytoma · pituitary gland acidophil adenoma · pituitary gland basophil adenoma · plasma cell myeloma · primary peritoneal carcinoma · progesterone-receptor positive breast cancer · prolactin-producing pituitary gland adenoma · prostate adenocarcinoma · rectal cancer · rectal signet ring cell adenocarcinoma · rectum adenocarcinoma · rectum mucinous adenocarcinoma · rhabdomyosarcoma · small cell lung carcinoma · small intestine leiomyosarcoma · superficial spreading melanoma · synovial sarcoma · T-cell childhood acute lymphocytic leukemia · T-cell large granular lymphocyte leukemia · TSH-secreting pituitary adenoma · undifferentiated pleomorphic sarcoma · uterine adnexa cancer · uterine corpus sarcoma · Wilms tumor · yolk sac tumor of central nervous system
Investigated by
National Cancer Institute (NCI) · Hoffmann-La Roche · M.D. Anderson Cancer Center

Trials 35

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 118 trials
Phase 1 NCT01269411 Jul 2011 → Feb 2012 adult brainstem glioma, adult glioblastoma, anaplastic oligodendroglioma, giant cell glioblastoma +1 National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT01238133 Dec 2010 → Jan 2014 female breast carcinoma, triple-negative breast carcinoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT01208441 Nov 2010 → Dec 2011 Her2-receptor negative breast cancer, estrogen-receptor positive breast cancer, female breast carcinoma, progesterone-receptor positive breast cancer National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT01236586 Oct 2010 → Apr 2011 Wilms tumor, brain neoplasm, lymphoma, osteosarcoma National Cancer Institute (NCI) Withdrawn No outcome recorded
Phase 1 NCT01149356 Oct 2010 → Dec 2012 Her2-receptor negative breast cancer, estrogen-receptor positive breast cancer, female breast carcinoma, male breast carcinoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT01218620 Sep 2010 → Jul 2012 neoplasm National Cancer Institute (NCI) Completed No outcome recorded
Phase 1 NCT01198535 Sep 2010 → Jul 2012 colon mucinous adenocarcinoma, colon signet ring cell adenocarcinoma, rectal signet ring cell adenocarcinoma, rectum mucinous adenocarcinoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT01193881 Aug 2010 → Aug 2015 non-small cell lung carcinoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT01192763 Aug 2010 → Jan 2012 pancreatic adenocarcinoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT01198184 Aug 2010 → Jul 2013 cancer of unknown primary site, endometrial carcinoma, endometrial serous adenocarcinoma, renal cell carcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 1/24 trials
Phase 1/2 NCT01189240 Dec 2010 → Jan 2013 adult glioblastoma, anaplastic astrocytoma, anaplastic oligodendroglioma, giant cell glioblastoma +1 National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1/2 NCT01217411 Oct 2010 → Nov 2011 HER2 positive breast carcinoma, Her2-receptor negative breast cancer, cutaneous melanoma, male breast carcinoma +3 National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1/2 NCT01196416 Aug 2010 → Aug 2015 cutaneous melanoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 1/2 NCT01154452 Jun 2010 → Feb 2015 Ewing sarcoma/peripheral primitive neuroectodermal tumor, Kaposi's sarcoma, adult epithelioid sarcoma, adult extraskeletal osteosarcoma +18 National Cancer Institute (NCI) Completed No outcome recorded
Phase 213 trials
Phase 2 NCT01251172 Dec 2010 → Jul 2012 plasma cell myeloma National Cancer Institute (NCI) Withdrawn No outcome recorded
Phase 2 NCT01270438 Dec 2010 → Aug 2011 colon adenocarcinoma, rectum adenocarcinoma National Cancer Institute (NCI) Withdrawn No outcome recorded
Phase 2 NCT01122901 Dec 2010 → Aug 2015 adult glioblastoma, giant cell glioblastoma, gliosarcoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 2 NCT01232829 Oct 2010 → Jul 2012 pancreatic adenocarcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT01120275 Oct 2010 → May 2013 acral lentiginous melanoma, lentigo maligna melanoma, nodular malignant melanoma, superficial spreading melanoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 2 NCT01216787 Sep 2010 → Nov 2011 melanoma National Cancer Institute (NCI) Withdrawn No outcome recorded
Phase 2 NCT01193868 Sep 2010 → Apr 2014 non-small cell lung carcinoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 2 NCT01200810 Aug 2010 → Aug 2012 prostate adenocarcinoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 2 NCT01175343 Jul 2010 → Oct 2012 fallopian tube carcinoma, ovarian carcinoma, primary peritoneal carcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT01151449 Jun 2010 → Jul 2012 male breast carcinoma, triple-negative breast carcinoma National Cancer Institute (NCI) Terminated No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 35 sources stand behind the page.

FieldValueCited text
Known as RG4733 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00532090 ↗
Known as NSC-749225 “Phase II Study of RO4929097 (NSC-749225) in Advanced Melanoma” NCT01120275 ↗
Known as RO4929097 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01193868 ↗
33

NCT01208441 ↗

NCT01251172 ↗

NCT01196416 ↗

NCT01119599 ↗

NCT01120275 ↗

NCT01232829 ↗

NCT01070927 ↗

NCT01218620 ↗

NCT01198535 ↗

NCT01198184 ↗

Show 23 more sources

Action Inhibit “a Gamma-secretase Inhibitor” NCT01070927 ↗
Modality Small molecule “RO4929097, an oral small molecule inhibitor of gamma-secretase” NCT01088763 ↗
Route Oral “Administered orally daily at ascending doses to successive cohorts of patients” NCT00532090 ↗