Drugs / RG4733
last change Aug 2015 re-read 2 minutes ago

RG4733

also known as RO4929097 · NSC-749225

Small molecule

Developed for
adult glioblastoma · female breast carcinoma · giant cell glioblastoma · gliosarcoma · male breast carcinoma · non-small cell lung carcinoma · Her2-receptor negative breast cancer · adult brainstem glioma
+120 more · anaplastic astrocytoma · anaplastic oligodendroglioma · cancer of unknown primary site · cutaneous melanoma · pancreatic adenocarcinoma · triple-negative breast carcinoma · anaplastic large cell lymphoma · benign meningioma · Burkitt lymphoma · craniopharyngioma · ependymoblastoma · estrogen-receptor positive breast cancer · grade II meningioma · grade III lymphomatoid granulomatosis · Hodgkins lymphoma · neoplasm · ovarian carcinoma · rectal carcinoma · renal cell carcinoma · subependymal giant cell astrocytoma · supratentorial primitive neuroectodermal tumor · acoustic neuroma · acral lentiginous melanoma · adult anaplastic ependymoma · adult brain ependymoma · adult choroid plexus neoplasm · adult epithelioid sarcoma · adult extraskeletal osteosarcoma · adult fibrosarcoma · adult intracranial malignant hemangiopericytoma · adult liposarcoma · adult malignant mesenchymoma · adult medulloblastoma · adult oligodendroglioma · adult papillary meningioma · adult pineoblastoma · alveolar soft part sarcoma · anaplastic ependymoma · anaplastic meningioma · atypical teratoid rhabdoid tumor · brain neoplasm · central nervous system melanocytic neoplasm · central nervous system teratoma · childhood brain stem glioma · childhood central nervous system germinoma · childhood central nervous system mixed germ cell tumor · childhood cerebellar astrocytic neoplasm · childhood cerebral astrocytoma · childhood choroid plexus neoplasm · childhood medulloblastoma · childhood oligodendroglioma · childhood spinal cord tumor · chondrosarcoma · chromophobe adenoma · clear cell renal carcinoma · clear cell sarcoma of kidney · colon adenocarcinoma · colon carcinoma · colon mucinous adenocarcinoma · colon signet ring cell adenocarcinoma · dermatofibrosarcoma protuberans · desmoplastic small round cell tumor · diffuse astrocytoma · endometrial carcinoma · endometrial serous adenocarcinoma · epithelioid hemangioendothelioma · Ewing sarcoma/peripheral primitive neuroectodermal tumor · exocrine pancreatic carcinoma · extraskeletal myxoid chondrosarcoma · fallopian tube carcinoma · gastrointestinal stromal tumor · grade III meningioma · HER2 positive breast carcinoma · Kaposi's sarcoma · lentigo maligna melanoma · lymphoma · malignant colon neoplasm · malignant peripheral nerve sheath tumor · medulloepithelioma · melanoma · metastasis from malignant tumor of colon · metastatic malignant neoplasm in the brain · mixed glioma · myxopapillary ependymoma · nodular malignant melanoma · optic pathway glioma · osteosarcoma · ovarian germ cell tumor · ovarian sarcoma · pediatric CNS choriocarcinoma · pediatric infratentorial ependymoma · pediatric supratentorial ependymoma · pilocytic astrocytoma · pineal gland astrocytoma · pineoblastoma · pineocytoma · pituitary gland acidophil adenoma · pituitary gland basophil adenoma · plasma cell myeloma · primary peritoneal carcinoma · progesterone-receptor positive breast cancer · prolactin-producing pituitary gland adenoma · prostate adenocarcinoma · rectal cancer · rectal signet ring cell adenocarcinoma · rectum adenocarcinoma · rectum mucinous adenocarcinoma · rhabdomyosarcoma · small cell lung carcinoma · small intestine leiomyosarcoma · superficial spreading melanoma · synovial sarcoma · T-cell childhood acute lymphocytic leukemia · T-cell large granular lymphocyte leukemia · TSH-secreting pituitary adenoma · undifferentiated pleomorphic sarcoma · uterine adnexa cancer · uterine corpus sarcoma · Wilms tumor · yolk sac tumor of central nervous system
Investigated by
National Cancer Institute (NCI) · Hoffmann-La Roche · M.D. Anderson Cancer Center

Trials 35 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 118 trials
Phase 1 NCT01269411 Jul 2011 → Feb 2012 adult brainstem glioma, adult glioblastoma, anaplastic oligodendroglioma, giant cell glioblastoma +1 National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT01238133 Dec 2010 → Jan 2014 female breast carcinoma, triple-negative breast carcinoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT01208441 Nov 2010 → Dec 2011 Her2-receptor negative breast cancer, estrogen-receptor positive breast cancer, female breast carcinoma, progesterone-receptor positive breast cancer National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT01236586 Oct 2010 → Apr 2011 Wilms tumor, brain neoplasm, lymphoma, osteosarcoma National Cancer Institute (NCI) Withdrawn No outcome recorded
Phase 1 NCT01149356 Oct 2010 → Dec 2012 Her2-receptor negative breast cancer, estrogen-receptor positive breast cancer, female breast carcinoma, male breast carcinoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT01198535 Sep 2010 → Jul 2012 colon mucinous adenocarcinoma, colon signet ring cell adenocarcinoma, rectal signet ring cell adenocarcinoma, rectum mucinous adenocarcinoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT01218620 Sep 2010 → Jul 2012 neoplasm National Cancer Institute (NCI) Completed No outcome recorded
Phase 1 NCT01192763 Aug 2010 → Jan 2012 pancreatic adenocarcinoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT01193881 Aug 2010 → Aug 2015 non-small cell lung carcinoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT01198184 Aug 2010 → Jul 2013 cancer of unknown primary site, endometrial carcinoma, endometrial serous adenocarcinoma, renal cell carcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 1/24 trials
Phase 1/2 NCT01189240 Dec 2010 → Jan 2013 adult glioblastoma, anaplastic astrocytoma, anaplastic oligodendroglioma, giant cell glioblastoma +1 National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1/2 NCT01217411 Oct 2010 → Nov 2011 HER2 positive breast carcinoma, Her2-receptor negative breast cancer, cutaneous melanoma, male breast carcinoma +3 National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1/2 NCT01196416 Aug 2010 → Aug 2015 cutaneous melanoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 1/2 NCT01154452 Jun 2010 → Feb 2015 Ewing sarcoma/peripheral primitive neuroectodermal tumor, Kaposi's sarcoma, adult epithelioid sarcoma, adult extraskeletal osteosarcoma +18 National Cancer Institute (NCI) Completed No outcome recorded
Phase 213 trials
Phase 2 NCT01122901 Dec 2010 → Aug 2015 adult glioblastoma, giant cell glioblastoma, gliosarcoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 2 NCT01270438 Dec 2010 → Aug 2011 colon adenocarcinoma, rectum adenocarcinoma National Cancer Institute (NCI) Withdrawn No outcome recorded
Phase 2 NCT01251172 Dec 2010 → Jul 2012 plasma cell myeloma National Cancer Institute (NCI) Withdrawn No outcome recorded
Phase 2 NCT01120275 Oct 2010 → May 2013 acral lentiginous melanoma, lentigo maligna melanoma, nodular malignant melanoma, superficial spreading melanoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 2 NCT01232829 Oct 2010 → Jul 2012 pancreatic adenocarcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT01193868 Sep 2010 → Apr 2014 non-small cell lung carcinoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 2 NCT01216787 Sep 2010 → Nov 2011 melanoma National Cancer Institute (NCI) Withdrawn No outcome recorded
Phase 2 NCT01200810 Aug 2010 → Aug 2012 prostate adenocarcinoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 2 NCT01175343 Jul 2010 → Oct 2012 fallopian tube carcinoma, ovarian carcinoma, primary peritoneal carcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT01151449 Jun 2010 → Jul 2012 male breast carcinoma, triple-negative breast carcinoma National Cancer Institute (NCI) Terminated No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 35 sources stand behind the page.

FieldValueCited text
Known as RG4733 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00532090
Known as NSC-749225 “Phase II Study of RO4929097 (NSC-749225) in Advanced Melanoma” NCT01120275
Known as RO4929097 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01120275
33

NCT01193868

NCT01198184

NCT01192763

NCT01070927

NCT01151449

NCT01217411

NCT01238133

NCT01216787

NCT01131234

NCT01071564

NCT01149356

NCT01096355

NCT01198535

NCT01232829

NCT01236586

NCT01269411

NCT01218620

NCT01116687

NCT01141569

NCT01200810

NCT01088763

NCT01189240

NCT01122901

NCT01208441

NCT01158274

NCT01145456

NCT01270438

NCT01175343

NCT01193881

NCT01119599

NCT01154452

NCT01251172

NCT01196416

Action Inhibit “a Gamma-secretase Inhibitor” NCT01070927
Modality Small molecule “RO4929097, an oral small molecule inhibitor of gamma-secretase” NCT01088763
Route Oral “Administered orally daily at ascending doses to successive cohorts of patients” NCT00532090