Drugs / Entinostat
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Entinostat

also known as BAY 86-5274 · KHK2375 · MS-27-275 · MS-275 · MS-275-27 · SNDX-275 · ZK 244894

Small molecule targets HDAC1, HDAC3 via inhibition

Developed for
breast cancer · non-small cell lung carcinoma · myelodysplastic syndrome · triple-negative breast carcinoma · acute myeloid leukemia with t(8;21)(q22;q22) translocation · adult acute lymphoblastic leukemia · chronic myelomonocytic leukemia · estrogen-receptor positive breast cancer
+101 more · female breast carcinoma · HER2 positive breast carcinoma · invasive breast carcinoma · melanoma · renal cell carcinoma · acute myeloblastic leukemia with maturation · acute myeloblastic leukemia without maturation · acute myeloid leukemia · acute myeloid leukemia with 11q23 abnormalities · acute myeloid leukemia with minimal differentiation · acute myelomonocytic leukemia M4 · adult acute monocytic leukemia · breast adenocarcinoma · colorectal cancer · Hodgkins lymphoma · lymphoma · pancreatic adenocarcinoma · refractory malignant neoplasm · urinary bladder cancer · acute basophilic leukemia · acute biphenotypic leukemia · acute erythroid leukemia · acute megakaryoblastic leukemia · acute megakaryoblastic leukemia in adult · acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent · acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) · acute myeloid leukemia with t(9;11)(p22;q23) · acute myeloid leukemia, inv(16)(p13.1;q22) · acute myeloid leukemia, t(16;16)(p13.1;q22) · acute promyelocytic leukemia · adult lymphoma · adult T-cell leukemia/lymphoma · aggressive B-cell non-Hodgkin lymphoma · anaplastic large cell lymphoma · angioimmunoblastic T-cell lymphoma · anus cancer · B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) · blast phase chronic myelogenous leukemia, BCR-ABL1 positive · brainstem neoplasm · breast neoplasm · Burkitt lymphoma · cancer · cancer of unknown primary site · central nervous system neoplasm · central nervous system non-hodgkin lymphoma · cervical cancer · cholangiocarcinoma · chronic lymphocytic leukemia/small lymphocytic lymphoma · digestive system carcinoma · digestive system neuroendocrine neoplasm · endometrial endometrioid adenocarcinoma · erythroleukemia · esophageal cancer · fallopian tube carcinosarcoma · fallopian tube clear cell adenocarcinoma · fallopian tube endometrioid adenocarcinoma · fallopian tube serous adenocarcinoma · grade III lymphomatoid granulomatosis · Her2-receptor negative breast cancer · hormone receptor-positive breast cancer · intraocular lymphoma · large-cell immunoblastic lymphoma · leukemia · male breast carcinoma · malignant pancreatic neoplasm · MALT lymphoma · mantle cell lymphoma · metastatic carcinoma · metastatic malignant neoplasm · mycosis fungoides and variants · myelodysplastic syndrome with excess blasts · myelodysplastic syndrome with multilineage dysplasia · myelodysplastic syndrome with ring sideroblasts · myelodysplastic/myeloproliferative disease · myeloproliferative neoplasm, unclassifiable · nodal marginal zone B-cell lymphoma · optic pathway glioma · oropharyngeal carcinoma · ovarian carcinosarcoma · ovarian clear cell adenocarcinoma · ovarian endometrioid adenocarcinoma · ovarian serous adenocarcinoma · penile cancer · pineal body neoplasm · plasma cell neoplasm · primary peritoneal serous adenocarcinoma · prostate adenocarcinoma · rectal cancer · small cell lung carcinoma · small intestine lymphoma · splenic marginal zone lymphoma · T-cell non-Hodgkin lymphoma · uveal melanoma · vaginal cancer · vulva cancer · Waldenstrom macroglobulinemia · estrogen-receptor negative breast cancer · fallopian tube cancer · malignant epithelial tumor of ovary · neoplasm · peritoneum cancer
Investigated by
National Cancer Institute (NCI) · Syndax Pharmaceuticals · Merck Sharp & Dohme LLC · Bristol-Myers Squibb · Roberto Pili · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
+30 more · UNC Lineberger Comprehensive Cancer Center · Abramson Cancer Center at Penn Medicine · Indiana University · Kyowa Kirin, Inc. · Taizhou EOC Pharma Co., Ltd. · Tianjin Medical University Cancer Institute and Hospital · Antonio Fojo · AstraZeneca · Bayer · Celgene Corporation · Clinigen, Inc. · Genentech, Inc. · George Washington University · German Cancer Research Center · Hetty Carraway · Hoffmann-La Roche · Memorial Sloan Kettering Cancer Center · NRG Oncology · National Institutes of Health Clinical Center (CC) · Rhone-Poulenc Rorer · Rising Tide Foundation · Stand Up To Cancer · Sun Yat-sen University · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · University Hospital Heidelberg · University of Maryland, Baltimore · University of Virginia · Vanderbilt-Ingram Cancer Center · Vastra Gotaland Region · Zhejiang Cancer Hospital

Trials 69 · started per year

today
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 02 trials
Phase 0 NCT03361800 Nov 2018 → Sep 2019 invasive breast carcinoma, triple-negative breast carcinoma UNC Lineberger Comprehensive Cancer Center Terminated No outcome recorded
Phase 0 NCT03018249 Oct 2017 → Apr 2018 endometrial endometrioid adenocarcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 126 trials
Phase 1 NCT04296942 May → Oct 2021 HER2 positive breast carcinoma, triple-negative breast carcinoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT04631029 Apr → Dec 2021 metastatic malignant neoplasm in the brain, small cell lung carcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 1 NCT03760614 Jan 2021 → Jul 2022 pancreatic adenocarcinoma Abramson Cancer Center at Penn Medicine Withdrawn No outcome recorded
Phase 1 NCT03924245 Oct 2020 → Feb 2022 fallopian tube carcinosarcoma, fallopian tube clear cell adenocarcinoma, fallopian tube endometrioid adenocarcinoma, fallopian tube serous adenocarcinoma +5 Vanderbilt-Ingram Cancer Center Terminated No outcome recorded
Phase 1 NCT03925428 Sep 2020 T-cell non-Hodgkin lymphoma, adult lymphoma, aggressive B-cell non-Hodgkin lymphoma, pancreatic adenocarcinoma +1 National Cancer Institute (NCI) Withdrawn No outcome recorded
Phase 1 NCT03829930 May 2019 → Sep 2020 prostate adenocarcinoma George Washington University Terminated No outcome recorded
Phase 1 NCT03473639 Jan 2019 → Sep 2021 breast cancer University of Virginia Completed No outcome recorded
Phase 1 NCT03215264 Oct 2017 → Jun 2020 colorectal cancer Abramson Cancer Center at Penn Medicine Completed No outcome recorded
Phase 1 NCT03192111 Jul → Nov 2017 impaired renal function disease Syndax Pharmaceuticals Completed No outcome recorded
Phase 1 NCT02936752 Jun 2017 → Nov 2022 myelodysplastic syndrome National Cancer Institute (NCI) Completed No outcome recorded
Phase 1/213 trials
Phase 1/2 NCT07261592 Dec 2025 → Sep 2028 expected urinary bladder cancer The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Not yet recruiting No outcome recorded
Phase 1/2 NCT07708194 Jun 2025 → Feb 2027 expected HER2 positive breast carcinoma, hormone receptor-positive breast cancer Tianjin Medical University Cancer Institute and Hospital Recruiting No outcome recorded
Phase 1/2 NCT05898828 Aug 2024 esophageal cancer National Cancer Institute (NCI) Withdrawn No outcome recorded
Phase 1/2 NCT05053971 Nov 2022 → Jul 2027 expected digestive system carcinoma, metastatic carcinoma, refractory malignant neoplasm National Cancer Institute (NCI) Recruiting No outcome recorded
Phase 1/2 NCT04708470 Oct 2021 → Nov 2026 expected anus cancer, cervical cancer, human papilloma virus infection, oropharyngeal carcinoma +3 National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 1/2 NCT03838042 May 2020 → Jun 2026 overdue central nervous system neoplasm University Hospital Heidelberg Recruiting No outcome recorded
Phase 1/2 NCT03280563 Dec 2017 → Sep 2024 breast neoplasm Hoffmann-La Roche Completed No outcome recorded
Phase 1/2 NCT03024437 Jun 2017 → Jun 2024 metastatic malignant neoplasm, renal cell carcinoma Roberto Pili Terminated No outcome recorded
Phase 1/2 NCT02437136 Aug 2015 → Sep 2022 colorectal cancer, melanoma, non-small cell lung carcinoma Syndax Pharmaceuticals Completed No outcome recorded
Phase 1/2 NCT01383447 Oct 2010 → Apr 2012 B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2), adult acute lymphoblastic leukemia National Cancer Institute (NCI) Terminated No outcome recorded
Phase 227 trials
Phase 2 NCT07441486 Apr 2026 overdue breast cancer Tianjin Medical University Cancer Institute and Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07235618 Jan 2026 → Jan 2028 expected breast cancer Sun Yat-sen University Not yet recruiting No outcome recorded
Phase 2 NCT07330544 Nov 2025 → Nov 2027 expected breast cancer Zhejiang Cancer Hospital Recruiting No outcome recorded
Phase 2 NCT03978624 Sep 2020 → Mar 2024 overdue urinary bladder cancer UNC Lineberger Comprehensive Cancer Center Active not recruiting No outcome recorded
Phase 2 NCT03765229 Mar 2019 → Dec 2022 melanoma UNC Lineberger Comprehensive Cancer Center Completed No outcome recorded
Phase 2 NCT03552380 Jul 2018 → Jun 2022 renal cell carcinoma Roberto Pili Terminated No outcome recorded
Phase 2 NCT03501381 May 2018 → Jan 2023 overdue renal cell carcinoma Roberto Pili Active not recruiting No outcome recorded
Phase 2 NCT02697630 Feb 2018 → Jan 2023 uveal melanoma Vastra Gotaland Region Completed No outcome recorded
Phase 2 NCT03211988 Dec 2017 → Aug 2021 digestive system neuroendocrine neoplasm Antonio Fojo Terminated No outcome recorded
Phase 2 NCT03250273 Nov 2017 → Nov 2020 cholangiocarcinoma, malignant pancreatic neoplasm Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Completed No outcome recorded
Phase 31 trial
Phase 3 NCT02115282 Mar 2014 → May 2020 overdue Her2-receptor negative breast cancer, breast adenocarcinoma, female breast carcinoma National Cancer Institute (NCI) Active not recruiting No outcome recorded
Also used as a comparator or background therapy in 8 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT02922933 Comparator Oct 2016 → Apr 2017 Syndax Pharmaceuticals Completed No outcome recorded
Phase 1 NCT02909452 Comparator Sep 2016 → Jul 2019 breast disorder, bronchial neoplasm, digestive system neoplasm, endocrine gland neoplasm +3 Syndax Pharmaceuticals Completed No outcome recorded
Phase 1 NCT02897778 Comparator Aug 2016 → Mar 2017 breast neoplasm, bronchial neoplasm, digestive system neoplasm, endocrine gland neoplasm +3 Syndax Pharmaceuticals Completed No outcome recorded
Phase 1 NCT02820961 Comparator Jun 2016 → Sep 2018 estrogen-receptor positive breast cancer Syndax Pharmaceuticals Completed No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT02915523 Comparator Dec 2016 → Feb 2019 fallopian tube cancer, malignant epithelial tumor of ovary, peritoneum cancer Syndax Pharmaceuticals Completed No outcome recorded
Phase 1/2 NCT02708680 Comparator May 2016 → Mar 2021 breast cancer Syndax Pharmaceuticals Completed No outcome recorded
Phase 21 trial
Phase 2 NCT07492394 Comparator Sep 2025 → Dec 2026 expected breast cancer Hebei Medical University Fourth Hospital Recruiting No outcome recorded
Phase 31 trial
Phase 3 NCT03538171 Comparator May 2018 → Jul 2021 breast cancer Taizhou EOC Pharma Co., Ltd. Unknown No outcome recorded

Evidence & citations 13 cited values

Every value below carries the sentence it was read from. 79 sources stand behind the page.

FieldValueCited text
Known as entinostat ClinicalTrials.gov intervention name — accepted as the source's own label NCT07492394
73

NCT03018249

NCT03473639

NCT00828854

NCT02922946

NCT02897778

NCT03924245

NCT00015925

NCT03760614

NCT00676663

NCT03838042

NCT03978624

NCT03187015

NCT01038778

NCT03765229

NCT01935947

NCT03179930

NCT01383447

NCT02708680

NCT01132573

NCT01349959

NCT07261592

NCT00101179

NCT02915523

NCT03501381

NCT02833155

NCT05053971

NCT01234532

NCT00387465

NCT03280563

NCT03211988

NCT02936752

NCT05898828

NCT03250273

NCT01434303

NCT02909452

NCT07235618

NCT01594398

NCT00020579

NCT00602030

NCT01105377

NCT01886573

NCT07708194

NCT02820961

NCT01928576

NCT02115594

NCT02697630

NCT04631029

NCT00462605

NCT04296942

NCT03192111

NCT07330544

NCT03538171

NCT03361800

NCT02115282

NCT00866333

NCT01159301

NCT01305499

NCT03829930

NCT03291886

NCT07441486

NCT03552380

NCT02922933

NCT03215264

NCT03024437

NCT01207726

NCT00098891

NCT02453620

NCT03925428

NCT02780804

NCT00750698

NCT04708470

NCT02437136

NCT00313586

Known as BAY 86-5274 “Histone Deacetylase Inhibitor, MS-275 (BAY 86-5274, ZK 244894)” NCT00185302
Known as KHK2375 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02623751
Known as MS-27-275 ChEMBL registry synonym — accepted as the source's own label CHEMBL27759
Known as MS-275 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00185302
Known as MS-275-27 ChEMBL registry synonym — accepted as the source's own label CHEMBL27759
Known as SNDX-275 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00754312
Known as ZK 244894 “Histone Deacetylase Inhibitor, MS-275 (BAY 86-5274, ZK 244894)” NCT00185302
Action Inhibit “MS-275 may stop the growth of cancer cells by blocking the enzymes necessary for their growth.” NCT00098891
Modality Small molecule “The benzamide derivative entinostat inhibits histone deacetylase and induces histone hyperacetylation.” PMID 34563945 Sep 2021
Route Oral “Given orally” NCT00098891
Target HDAC1 “Entinostat is an oral HDAC inhibitor that selectively inhibits class I (primarily HDAC1 and HDAC3) and class IV HDACs.” NCT07492394
Target HDAC3 “Entinostat is an oral HDAC inhibitor that selectively inhibits class I (primarily HDAC1 and HDAC3) and class IV HDACs.” NCT07492394