Drugs / Lactobacillus
last change Jun 2026 re-read 9 days ago

Lactobacillus

Developed for
irritable bowel syndrome · acute graft versus host disease · aphthous stomatitis · cervical lymphadenitis · chronic diarrheal disease · constipation disorder · diabetes mellitus · Parkinson disease
+10 more · periodic fever syndrome · pharyngitis · preterm premature rupture of the membranes · type 1 diabetes mellitus · urinary bladder cancer · bacterial vaginosis · human papilloma virus infection · seasonal allergic rhinitis · systemic sclerosis · vulvovaginal candidiasis
Investigated by
Beijing Friendship Hospital · Binzhou Medical University · Binzhou People's Hospital · Connecticut Children's Medical Center · Dongying People's Hospital · DuPont Nutrition and Health
+28 more · First Affiliated Hospital Xi'an Jiaotong University · Georgetown University · Institute of Hematology & Blood Diseases Hospital, China · Jinan Central Hospital · Jining First People's Hospital · Liaocheng People's Hospital · National Center for Research Resources (NCRR) · Qianfoshan Hospital · Qilu Hospital of Shandong University · Qingdao Municipal Hospital · Ricardo A Gutierrez Ramirez, MD, MSc, FACOG · Rizhao People's Hospital · Shandong Cancer Hospital and Institute · Shandong Provincial Hospital · Shenzhen People's Hospital · Soochow University · The Affiliated Hospital of Qingdao University · The First Affiliated Hospital of Soochow University · The Gerber Foundation · The People's Hospital of Jimo.Qingdao · The Second Hospital of Shandong University · Tianjin Medical University Second Hospital · Universidad Nacional Autonoma de Honduras · Weifang Medical University · Weifang People's Hospital · Weihai Central Hospital · Weihai Municipal Hospital · Yantai Yuhuangding Hospital

Trials 11

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT06960369 Dec 2024 → Jun 2026 overdue chronic diarrheal disease, irritable bowel syndrome The First Affiliated Hospital of Soochow University Recruiting No outcome recorded
Phase 21 trial
Phase 2 NCT02535962 Oct 2016 → Sep 2017 aphthous stomatitis, cervical lymphadenitis, periodic fever syndrome, pharyngitis Connecticut Children's Medical Center Withdrawn No outcome recorded
Phase 31 trial · 1 missed
Phase 3 NCT00492583 Jul 2007 → Aug 2008 — Georgetown University Completed Missed primary
Phase 44 trials
Phase 4 NCT05366335 Jul → Oct 2022 constipation disorder, irritable bowel syndrome First Affiliated Hospital Xi'an Jiaotong University Unknown No outcome recorded
Phase 4 NCT05220124 Jan 2022 → Nov 2024 urinary bladder cancer Tianjin Medical University Second Hospital Unknown No outcome recorded
Phase 4 NCT04871464 Nov 2021 → Oct 2023 Parkinson disease, movement disorder, neurodegenerative disease Beijing Friendship Hospital Unknown No outcome recorded
Phase 4 NCT03556631 Sep 2020 → Sep 2021 type 1 diabetes mellitus Shenzhen People's Hospital Completed No outcome recorded
Phase not applicable4 trials
— NCT07188909 Sep 2025 → Mar 2026 overdue acute graft versus host disease Institute of Hematology & Blood Diseases Hospital, China Not yet recruiting No outcome recorded
— NCT06788132 Jan → Jul 2025 preterm premature rupture of the membranes Ricardo A Gutierrez Ramirez, MD, MSc, FACOG Completed No outcome recorded
— NCT05901779 Apr 2023 → Mar 2024 gastric cancer The Affiliated Hospital of Qingdao University Unknown No outcome recorded
— NCT00011141 — diabetes mellitus National Center for Research Resources (NCRR) Completed No outcome recorded
Comparator or background therapy5 trials
Phase 1/2 NCT00746226 Comparator Mar → Jun 2006 seasonal allergic rhinitis Danisco Completed No outcome recorded
Phase 4 NCT04699240 Comparator Jul 2020 → Dec 2023 vulvovaginal candidiasis Peking University Shenzhen Hospital Completed No outcome recorded
Phase 4 NCT03099408 Comparator Jul 2017 → Dec 2020 bacterial vaginosis Peking University Shenzhen Hospital Completed No outcome recorded
Phase 4 NCT01497743 Comparator Feb 2012 → Feb 2013 systemic sclerosis University of Michigan Withdrawn No outcome recorded
— NCT06467942 Comparator Mar 2023 → Dec 2024 human papilloma virus infection Peking University People's Hospital Unknown No outcome recorded

News releases announcing trial results or a regulatory action · 5

DateIssuerRelease
2018-05-10 Lallemand Pharma AG Regulatory B. lactis LAFTI® B94 and L. helveticus LAFTI® L10 recognized for their health benefits by Health Canada lallemand.com ↗
Lallemand Health Solutions is pleased to announce that its documented probiotic strain Bifidobacterium animalis ssp. lactis LAFTI® B94 has been recognized by the Canadian Health Authorities for its gut health benefits in children, adolescents, and adults.
2017-06-12 Lallemand Pharma AG Results Publication of a safety and tolerance study for ProbioKid® strains in infants lallemand.com ↗
No serious adverse events were reported and the Spanish authors concluded that the use of the three probiotic strains in infancy is safe, and well tolerated.
2017-05-29 Lallemand Pharma AG Regulatory ProbioKid® and its specific probiotic strains recognized safe in both the US and Canada for use in young children lallemand.com ↗
A panel of independent renowned experts in the field of probiotics confirmed the GRAS status for infants and children while Health Canada approved the formula for children from 3 months old.
2017-02-27 Winclove Probiotics B.V. Results Probiotic supplements beneficially affect Tryptophan–Kynurenine Metabolism wincloveprobiotics.com ↗
The ratio of subjects taking the placebo who experienced one or more URTI symptoms was increased 2.2-fold compared to those on probiotics (PLA 0.79, PRO 0.35; p = 0.02).
2016-04-11 Lallemand Pharma AG Regulatory Probio’Stick: the first and only probiotic with approved health claims in the gut-brain axis area in Canada lallemand.com ↗
The Natural and Non-prescription Health Products Directorate (NNHPD), the regulatory agency for natural health products in Canada, has approved the following new strong claims for Probio’Stick (Claim NPN 80021343):

Evidence & citations 12 cited values

Every value below carries the sentence it was read from. 17 sources stand behind the page.

FieldValueCited text
Known as Lactobacillus “One capsule of cranberry extract 100mg equivalent 36 mg, hibiscus extract 20 mg, vitamin C 500 mg with lactobacillus 200 MU per day for 10 days” NCT06788132 ↗
6

“Target isolation and culture of core beneficial bacteria (Lactobacillus and Bifidobacterium)” NCT07188909 ↗

NCT03099408 ↗

NCT04699240 ↗

NCT00011141 ↗

NCT01497743 ↗

NCT06467942 ↗

Known as B. lactis “Active was a strawberry yogurt-based drink supplemented with Bifidobacterium animalis ssp. lactis (B. lactis) BB-12.” PMID 20216564 ↗ Mar 2010
Known as Bifidobacterium animalis ssp. lactis “Active was a strawberry yogurt-based drink supplemented with Bifidobacterium animalis ssp. lactis (B. lactis) BB-12.” PMID 20216564 ↗ Mar 2010
Known as Bifidobacterium lactis ClinicalTrials.gov intervention name — accepted as the source's own label NCT00492583 ↗
2

NCT02535962 ↗

NCT00746226 ↗

Known as Combined Bifidobacterium, Lactobacillus, Enterococcus and Bacillus cereus Tablets, Live “Live Probiotic tablet (Combined Bifidobacterium, Lactobacillus, Enterococcus and Bacillus cereus Tablets, Live)” NCT06960369 ↗
Known as Live Combined (Bifidobacterium,Lactobacillus and Enterococcus Capsules) ClinicalTrials.gov intervention name — accepted as the source's own label NCT05220124 ↗
1

NCT04871464 ↗

Known as live combined Bifidobacterium and Lactobacillus ClinicalTrials.gov intervention name — accepted as the source's own label NCT03556631 ↗
1

NCT05366335 ↗

Known as live combined Bifidobacteriun, Lactobacillus and Enterococcus ClinicalTrials.gov intervention name — accepted as the source's own label NCT05901779 ↗
Known as Live Probiotic tablet “Live Probiotic tablet (Combined Bifidobacterium, Lactobacillus, Enterococcus and Bacillus cereus Tablets, Live)” NCT06960369 ↗
Action Activate “oral administration of lactobacillus can boost NK-T cell activity in children with HIV without side effects” NCT00011141 ↗
Modality Other / unclassified “live combined Bifidobacterium and Lactobacillus preparation” NCT03556631 ↗
Route Oral “Oral lactobacillus administration” NCT00011141 ↗