Drugs / Lactobacillus
last change Jun 2026 re-read 2 minutes ago

Lactobacillus

Developed for
irritable bowel syndrome · acne · acute graft versus host disease · aphthous stomatitis · cervical lymphadenitis · chronic diarrheal disease · constipation disorder · diabetes mellitus
+14 more · occupational asthma · osteoarthritis, knee · Parkinson disease · periodic fever syndrome · pharyngitis · preterm premature rupture of the membranes · type 1 diabetes mellitus · urinary bladder cancer · bacterial vaginosis · human papilloma virus infection · periodontitis · seasonal allergic rhinitis · systemic sclerosis · vulvovaginal candidiasis
Investigated by
Beijing Friendship Hospital · Beni-Suef University · Binzhou Medical University · Binzhou People's Hospital · Connecticut Children's Medical Center · Dongying People's Hospital
+32 more · DuPont Nutrition and Health · First Affiliated Hospital Xi'an Jiaotong University · Georgetown University · Institute of Hematology & Blood Diseases Hospital, China · Jinan Central Hospital · Jining First People's Hospital · Liaocheng People's Hospital · National Center for Research Resources (NCRR) · Pak Emirates Military Hospital · Qianfoshan Hospital · Qilu Hospital of Shandong University · Qingdao Municipal Hospital · Ricardo A Gutierrez Ramirez, MD, MSc, FACOG · Rizhao People's Hospital · Shandong Cancer Hospital and Institute · Shandong Provincial Hospital · Shenzhen People's Hospital · Soochow University · The Affiliated Hospital of Qingdao University · The First Affiliated Hospital of Soochow University · The Gerber Foundation · The People's Hospital of Jimo.Qingdao · The Second Hospital of Shandong University · Tianjin Medical University Second Hospital · Universidad Nacional Autonoma de Honduras · University of Sao Paulo · University of Sao Paulo General Hospital · Weifang Medical University · Weifang People's Hospital · Weihai Central Hospital · Weihai Municipal Hospital · Yantai Yuhuangding Hospital

Trials 14 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT06960369 Dec 2024 → Jun 2026 overdue chronic diarrheal disease, irritable bowel syndrome The First Affiliated Hospital of Soochow University Recruiting No outcome recorded
Phase 21 trial
Phase 2 NCT02535962 Oct 2016 → Sep 2017 aphthous stomatitis, cervical lymphadenitis, periodic fever syndrome, pharyngitis Connecticut Children's Medical Center Withdrawn No outcome recorded
Phase 33 trials
Phase 3 NCT07364578 Feb 2025 → Feb 2026 overdue osteoarthritis, knee Beni-Suef University Recruiting No outcome recorded
Phase 3 NCT05629468 Oct 2021 → Jun 2022 acne Pak Emirates Military Hospital Completed No outcome recorded
Phase 3 NCT00492583 Jul 2007 → Aug 2008 Georgetown University Completed No outcome recorded
Phase 45 trials
Phase 4 NCT05366335 Jul → Oct 2022 constipation disorder, irritable bowel syndrome First Affiliated Hospital Xi'an Jiaotong University Unknown No outcome recorded
Phase 4 NCT05220124 Jan 2022 → Nov 2024 urinary bladder cancer Tianjin Medical University Second Hospital Unknown No outcome recorded
Phase 4 NCT04871464 Nov 2021 → Oct 2023 Parkinson disease, movement disorder, neurodegenerative disease Beijing Friendship Hospital Unknown No outcome recorded
Phase 4 NCT03556631 Sep 2020 → Sep 2021 type 1 diabetes mellitus Shenzhen People's Hospital Completed No outcome recorded
Phase 4 NCT03021161 Jan → Dec 2017 occupational asthma University of Sao Paulo Unknown No outcome recorded
Phase not applicable4 trials
NCT07188909 Sep 2025 → Mar 2026 overdue acute graft versus host disease Institute of Hematology & Blood Diseases Hospital, China Not yet recruiting No outcome recorded
NCT06788132 Jan → Jul 2025 preterm premature rupture of the membranes Ricardo A Gutierrez Ramirez, MD, MSc, FACOG Completed No outcome recorded
NCT05901779 Apr 2023 → Mar 2024 gastric cancer The Affiliated Hospital of Qingdao University Unknown No outcome recorded
NCT00011141 diabetes mellitus National Center for Research Resources (NCRR) Completed No outcome recorded
Also used as a comparator or background therapy in 7 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/22 trials
Phase 1/2 NCT02349360 Comparator Aug 2015 → Dec 2016 University of Florida Completed No outcome recorded
Phase 1/2 NCT00746226 Comparator Mar → Jun 2006 seasonal allergic rhinitis Danisco Completed No outcome recorded
Phase 31 trial
Phase 3 NCT06253988 Comparator Jan → Feb 2023 periodontitis Al-Azhar University Completed No outcome recorded
Phase 43 trials
Phase 4 NCT04699240 Comparator Jul 2020 → Dec 2023 vulvovaginal candidiasis Peking University Shenzhen Hospital Completed No outcome recorded
Phase 4 NCT03099408 Comparator Jul 2017 → Dec 2020 bacterial vaginosis Peking University Shenzhen Hospital Completed No outcome recorded
Phase 4 NCT01497743 Comparator Feb 2012 → Feb 2013 systemic sclerosis University of Michigan Withdrawn No outcome recorded
Phase not applicable1 trial
NCT06467942 Comparator Mar 2023 → Dec 2024 human papilloma virus infection Peking University People's Hospital Unknown No outcome recorded

Evidence & citations 15 cited values

Every value below carries the sentence it was read from. 23 sources stand behind the page.

FieldValueCited text
Known as Lactobacillus “One capsule of cranberry extract 100mg equivalent 36 mg, hibiscus extract 20 mg, vitamin C 500 mg with lactobacillus 200 MU per day for 10 days” NCT06788132
6

“Target isolation and culture of core beneficial bacteria (Lactobacillus and Bifidobacterium)” NCT07188909

NCT06467942

NCT00011141

NCT03099408

NCT04699240

NCT01497743

Known as B. lactis “Active was a strawberry yogurt-based drink supplemented with Bifidobacterium animalis ssp. lactis (B. lactis) BB-12.” PMID 20216564 Mar 2010
Known as Bifidobacterium animalis ssp. lactis “Active was a strawberry yogurt-based drink supplemented with Bifidobacterium animalis ssp. lactis (B. lactis) BB-12.” PMID 20216564 Mar 2010
Known as Bifidobacterium lactis ClinicalTrials.gov intervention name — accepted as the source's own label NCT02535962
2

NCT00746226

NCT00492583

Known as Combined Bifidobacterium, Lactobacillus, Enterococcus and Bacillus cereus Tablets, Live “Live Probiotic tablet (Combined Bifidobacterium, Lactobacillus, Enterococcus and Bacillus cereus Tablets, Live)” NCT06960369
Known as L. johnsonii N6.2 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02349360
Known as Lactobacillus johnsonii N6.2 Lactobacillus johnsonii N6.2 Modulates the Host Immune Responses: A Double-Blind, Randomized Trial in Healthy Adults.” PMID 28659913 Jun 2017
Known as live combined Bifidobacterium and Lactobacillus ClinicalTrials.gov intervention name — accepted as the source's own label NCT03556631
1

NCT05366335

Known as Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules ClinicalTrials.gov intervention name — accepted as the source's own label NCT04871464
1

NCT05220124

Known as live combined Bifidobacteriun, Lactobacillus and Enterococcus ClinicalTrials.gov intervention name — accepted as the source's own label NCT05901779
Known as Live Probiotic tablet Live Probiotic tablet (Combined Bifidobacterium, Lactobacillus, Enterococcus and Bacillus cereus Tablets, Live)” NCT06960369
Known as Probiotic Formula ClinicalTrials.gov intervention name — accepted as the source's own label NCT03021161
3

NCT07364578

NCT05629468

NCT06253988

Action Activate “oral administration of lactobacillus can boost NK-T cell activity in children with HIV without side effects” NCT00011141
Modality Other / unclassified “The purpose of this research study is to determine the effects of the probiotic, Lactobacillus johnsonii N6.2, on safety, gastrointestinal function, wellness, fecal bacteria...” NCT02349360
Route Oral Oral lactobacillus administration” NCT00011141